Knowledge Update

​Beijing, June 1 (IANS) SoftBank on Wednesday announced it will sell a four per cent stake in Alibaba Group in a sale that will see it dispose of shares in the Chinese e-commerce giant for the first time since it invested in 2000.

​San Francisco, May 27 (IANS) Microsoft and Facebook have joined hands to build a new, state-of-the-art subsea cable across the Atlantic Ocean that will help meet the growing customer demand for high speed, reliable connections for cloud and online services for Microsoft, Facebook and their customers.

​London, May 25 (IANS) London is projected to grow almost twice as fast as the rest of England over the next 10 years, the government's National Statistics Office (ONS) reported on Wednesday.

​London, June 1 (IANS) Countering a common perception, a new study has found no evidence of heart damage from long-term endurance training by elite master athletes.

While the media reports with depressing regularity the sudden cardiac death of endurance athletes, Belgium scientists earlier published a study that concluded that repeated bouts of intensive endurance exercise at the elite level may result in the pathological enlargement of the right ventricle, which, according to the article, is associated with potential health hazards including sudden cardiac death.

The publication of the study in European Heart Journal a few years ago was the cause of considerable debate among experts in the medical and sports communities. 

Sports medicine physicians at Saarland University in Germany have now tested the conclusions of that study by examining the hearts of elite master endurance athletes.

The findings of the latest study, published in the journal Circulation, refute the hypothesis proposed by their Belgian colleagues. 

The research team could find no evidence that years of elite-level endurance training causes any long-term damage to the right ventricle. 

The researchers examined 33 elite master athletes (average age: 47) and compared them to a control group of 33 men who were similar in terms of age, size and weight but who had not done any kind of endurance exercise. 

The group of athletes, which included former Olympians as well as previous Ironman participants and champions, have been training at an elite level for around 30 years and still continue to train for an average of about 17 hours a week.

The scientists were able to confirm that the hearts of these athletes, who have been engaged in elite level endurance activities for many years, were, as expected, significantly larger and stronger than those of members of the control group. 

"But we found no evidence of lasting damage, pathological enlargement or functional impairment of either the right or left ventricle in the athletes who had been doing long-term intensive elite-level endurance exercise,” explained one of the researchers Philipp Bohm, who is now working at University Hospital Zurich in Switzerland.​

​New York, May 27 (IANS) If you are facing the situation at home where your little one -- engaged in playing video games on smartphone or watching favourite cartoons on TV -- ignores your call to pick up a glass of water or switch off that AC, you are not alone.

According to the researchers, communication between mother-child is reducing as not just teenagers but even preschoolers hooked to smartphones, video games and television are not listening if asked a question or to do a household chore.

The findings also showed that children of mothers with graduate degrees had less electronic media exposure than kids of mothers with high school degrees or some college courses. 

"The kids whose mothers had advanced degrees often watched educational programmes. In addition, these highly educated mothers were more likely than other mothers to discuss media with their children," said lead study author Nicholas Waters from University of Michigan in the US.

Unlike previous research that has relied on self-reports by parents tracking their children's media usage, the team used enhanced audio equipment to track the home environment of preschoolers as they interacted with parents. 

They examined 44 families and the recordings averaged nearly 10 hours daily. 

The recordings documented the format of media used, duration and communication between the mother and child.

Researchers also examined demographic differences in media use and mother-child communication about media.

"Importantly, children of mothers with less than a graduate degree were exposed to media without any dialogue related to the media content for the vast majority of the time," added study co-author Sarah Domoff. 

This is important, she said, because parents' "active mediation" of television and other types of media may mitigate risks associated with media exposure.

The study was scheduled to be presented at the annual association for psychological science conference in Chicago on May 29.​

​Toronto, May 25 (IANS) Are you turning to artificial sweeteners or other sugar substitutes to lose weight? Although these sweeteners may help obese individuals reduce and cut calories, they may also have negative health effects, a study warns.

Artificial sweeteners are not digested by the body. However, the recent study suggests that bacteria in the gut may be able to break down artificial sweeteners, resulting in negative health effects. 

Currently, there are many new sugar substitutes that are used in foods and beverages and are marketed as "sugar-free" or "diet," including soft drinks, chewing gum, jellies, baked goods, candy, fruit juice and ice cream and yogurt.

"Our study shows that individuals with obesity who consume artificial sweeteners, particularly aspartame, may have worse glucose management than those who don't take sugar substitutes," said Jennifer Kuk from York University's school of kinesiology and health science in Canada.

For the study published in the journal Applied Physiology, Nutrition and Metabolism, data from 2,856 adults from the "Third National Health and Nutrition Survey" (NHANES III) was used. 

Individuals reported their diet over the past 24 hours and were categorised as consumers of artificial sweeteners -- aspartame or saccharin -- or high or low consumers of natural sugars -- sugar or fructose. 

The diabetes risk was measured as the ability to manage blood sugars using an oral glucose tolerance test.

The results showed that those who used artificial sweeteners, particularly aspartame, may have worse glucose management than those who don't take sugar substitutes

"We didn't find this adverse effect in those consuming saccharin or natural sugars," Kuk added.

"We will need to do future studies to determine whether any potentially negative health effects of artificial sweeteners outweigh the benefits for obesity reduction," Kuk stated.

Further investigation is needed to determine if there are any health effects of using these sweeteners, the researchers noted.​

Sydney, May 25 (IANS) A team of Australian researchers has demonstrated an optics breakthrough that can revamp night vision by making infra-red technology easy-to-use and cheap.

The team reported a dramatic increase in the absorption efficiency of light in a layer of semiconductor that is only a few hundred atoms thick -- to almost 99 percent light absorption from the current inefficient 7.7 percent.

This can save millions of dollars in defence and other areas using sensing devices, and boost applications of technology to a host of new areas such as agriculture.

Infra-red devices are used for improved vision through fog and for night vision and for observations not possible with visible light.

High-quality detectors cost approximately $100,000 and some require cooling to -200 degrees Celsius.

The team discovered perfect thin film light absorbers could be created simply by etching grooves into them.

“Conventional absorbers add bulk and cost to the infrared detector as well as the need for continuous power to keep the temperature down. The ultra-thin absorbers can reduce these drawbacks," said professor Martijn de Sterke, co-author from University of Sydney's school of physics.

By etching thin grooves in the film, the light is directed sideways and almost all of it is absorbed, despite the small amount of material.

There are many applications that could greatly benefit from perfectly absorbing ultra-thin films, ranging from defence and autonomous farming robots to medical tools and consumer electronics. The findings are forthcoming in the journal Optica.​

New York, June 1 (IANS) Researchers from Duke University have discovered a potential new class of small-molecule drugs that simultaneously block key targets in the treatment of pain.

The findings could lead to the development of a new drug to treat conditions including skin irritation and itching, headaches, jaw pain, and abdominal pain stemming from the pancreas and colon.

"We are very pleased with what is a first chapter in a highly promising story," said Wolfgang Liedtke, Professor at Duke University School of Medicine in Durham.

"We hope to be able to develop these compounds for clinical use in humans or animals," Liedtke noted.

In the new study, published in the journal Scientific Reports, the researchers initially aimed to develop more effective blockers of TRPV4, a molecule their previous research had shown transmits skin irritation elicited by sunburn, and painful sensations coming from the head and face. 

The researchers used a prototype TRPV4 blocker in a 2009 study and then set out to develop more potent versions.

Compared to the prototype, one of the new candidate drugs, called "16-8," worked 10 times more effectively in cells with active TRPV4 that are key for the development of osteoarthritis.

It also worked well in another cell type involved in nerve cell injury, stroke and epilepsy.

But to their surprise, when assessing the specificity of 16-8, the scientists discovered that it also blocked TRPA1, which is a promising target in pain and itch research.

"As a physician, I soon realised the enormous potential that these compounds might have, given how beneficial dual-target molecules can be in clinical medicine," Liedtke said.

In this study, the drug 16-8 also quelled pain in living animals, including abdominal aches in mice with pancreas inflammation. 

Liedtke sees potential for the 16-8 drug to treat osteoarthritis and other types of joint pain as well as head, face and jaw pain. 

In general, it might also treat aches radiating from internal organs or resulting from nerve cell injury, the study said.​

New York, June 1 (IANS) The side effects of antipsychotics can be quite problematic and researchers have found that the proportion of adolescents with autism or intellectual disability has increased among youths treated with these medications.

Antipsychotics are a class of psychiatric medication primarily used to manage psychosis, including delusions, hallucinations, paranoia or disordered thought and principally for schizophrenia and bipolar disorders.

The researchers also found that the number of adolescents with autism spectrum disorder being prescribed antipsychotics has also increased over the years in the US. 

For the study, the team performed a meta-analysis of 39 studies and over 350,000 youths with mental illness were examined on the frequency and time trends of antipsychotic prescribing in youth with autism spectrum disorders or intellectual disability.

"The side effects of antipsychotics drugs can be quite problematic, especially in children and adolescents," said lead researcher Christoph Correll from Hofstra University in the US. 

The results were published in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). 

Currently, second-generation antipsychotics are the only Food and Drug Administration-approved medications for youths with autism. However, these are approved only for the symptomatic control of irritability and aggression. 

Core symptoms of autism spectrum disorders (eg, social and communication difficulties) and core symptoms of intellectual disability, such as problems with understanding and responding appropriately to external data, did not appear to be affected by these medications. 

Clinicians need to consider using psychosocial interventions that are proven to be efficient for behavioural dysregulation such as irritability and aggression, before prescribing antipsychotics to adolescents with autism or intellectual disability, the researchers suggested.

When prescribing antipsychotics, it is imperative to regularly monitor both their efficacy and tolerability in patients through body weight, fasting lipids and glucose, extrapyramidal side effects, sedation, and sexual/reproductive adverse effects as well as to manage abnormalities appropriately, the researchers noted.​