Knowledge Update

​New York, June 28 (IANS) An experimental method that can kill up to 95 per cent of cancer cells in two hours may tremendously help people with inoperable or hard-to-reach tumours, as well as young children stricken with cancer, a study suggests.

The newly patented method to kill cancer cells has been developed by Matthew Gdovin, Associate Professor at University of Texas at San Antonio.

The new treatment involves injecting a chemical compound, nitrobenzaldehyde, into the tumour and allowing it to diffuse into the tissue. 

He then aims a beam of light at the tissue, causing the cells to become very acidic inside and, essentially, commit suicide. 

With this method, Gdovin estimated, up to 95 per cent of the targeted cancer cells die withing two hours.

The study was published in The Journal of Clinical Oncology.

"Even though there are many different types of cancers, the one thing they have in common is their susceptibility to this induced cell suicide," Gdovin said.

Gdovin tested his method against triple negative breast cancer, one of the most aggressive types of cancer and one of the hardest to treat. 

After one treatment in the laboratory, he was able to stop the tumor from growing and double chances of survival in mice.

Gdovin hopes that his non-invasive method will help cancer patients with tumors in areas that have proven problematic for surgeons, such as the brain stem, aorta or spine. 

It could also help people who have received the maximum amount of radiation treatment and can no longer cope with the scarring and pain that goes along with it, or children who are at risk of developing mutations from radiation as they grow older.

"There are so many types of cancer for which the prognosis is very poor," he said. 

"We're thinking outside the box and finding a way to do what for many people is simply impossible," Gdovin said.​

​New York, June 27 (IANS) Older people with high levels of “bad” or low-density lipoprotein (LDL-C) cholesterol live as long, and often longer, than their peers with low levels of the same cholesterol, a University of South Florida professor and an international team of experts have found.

The findings, which came after analysing past studies involving more than 68,000 participants over 60 years of age, call into question the "cholesterol hypothesis," which suggested that people with high cholesterol are more at risk of dying and would need statin drugs to lower cholesterol.

Appearing in the British Medical Journal (BMJ), the team's analysis represents the first review of a large group of prior studies on this issue.

"We have known for decades that high total cholesterol becomes a much weaker risk for cardiovascular disease with advancing age. In this analysis, we focused on the so-called "bad cholesterol" which has been blamed for contributing to heart disease,” said lead researcher David Diamond from the University of South Florida.

According to the authors, either a lack of association or an inverse relationship between LDL-C and cardiovascular deaths was present in each of the studies they evaluated. 

Subsequently, the team called for a re-evaluation of the need for drugs such as statins, which are aimed at reducing LDL-C as a step to prevent cardiovascular diseases.

"We found that several studies reported not only a lack of association between low LDL-C, but most people in these studies exhibited an inverse relationship, which means that higher LDL-C among the elderly is often associated with longer life," Diamond noted.

The research suggests that high cholesterol may be protective against diseases which are common in the elderly. 

For example, high levels of cholesterol are associated with a lower rate of neurological disorders, such as Parkinson's disease and Alzheimer's disease. 

Other studies have suggested that high LDL-C may protect against some often fatal diseases, such as cancer and infectious diseases, and that having low LDL-C may increase one's susceptibility to these diseases.

"Our results pose several relevant questions for future," said study leader and co-author health researcher Dr Uffe Ravnskov. 

"For example, why is total cholesterol a factor for cardiovascular disease for young and middle-age people, but not for the elderly? Why do a substantial number of elderly people with high LDL-C live longer than elderly people with low LDL-C?" he asked.

"Our findings provide a contradiction to the cholesterol hypothesis," Diamond said. ​

New York, June 27 (IANS) A gene responsible for the elimination of paternal mitochondria in the offspring has revealed how and why mitochondria are only passed on through a mother's egg and not the father's sperm.

Mitochondria, present inside the cells of nearly all multicellular animals, plants and fungi, organelles, plays an important role in generating the energy that cells need to survive. 

The findings showed that a gene CPS-6 serves as a paternal mitochondrial factor that is critical for its degradation.

Further, the enzyme that CPS-6 encodes first breaks down the interior membrane of the paternal mitochondria before moving to the space within the inner membrane to breakdown mitochondrial DNA.

CPS-6 plays a key role in initiating the self-destruction of paternal sperm, which likely benefits the embryo. 

Delayed removal of paternal mitochondria causes increased embryonic lethality, demonstrating that paternal mitochondrial elimination is important for normal animal development, the researchers explained. 

Shortly after a sperm penetrates an egg during fertilisation, the sperm's mitochondria are degraded while the egg's mitochondria persist. 

The paternal mitochondria were found to partially self-destruct before the mitochondria were surrounded by autophagosomes, which target components within a cell and facilitate their degradation, said Qinghua Zhou from the American Association for the Advancement of Science, a US-based nonprofit organisation.

For the study, the team analysed sperm mitochondria or paternal mitochondria in Caenorhabditis elegans -- a type of roundworm -- during early stages of development.​

Washington, June 28 (IANS) US space agency NASA is set to test-fire a booster for the world's most powerful rocket Space Launch System (SLS) which will power astronauts on the journey to Mars and on other deeper space missions

The booster will be fired up at Orbital ATK Propulsion Systems' test facilities in Promontory, Utah, at 7.05 p.m. (Indian standard time) on Tuesday.

The test will provide NASA with critical data to support booster qualification for flight.

This is the last time the booster will be fired in a test environment before the first test flight of SLS with NASA's Orion spacecraft, known as Exploration Mission-1 (EM-1), in 2018.

The first, full-scale booster qualification test was successfully completed in March 2015.

The SLS that will launch an uncrewed Orion spacecraft to a stable orbit beyond the Moon in 2018 will also carry 13 tiny satellites to test innovative ideas.

These small satellite secondary payloads or "CubeSats" will carry science and technology investigations to help pave the way for future human exploration in deep space, including the journey to Mars.

SLS' first flight, referred to as Exploration Mission-1 (EM-1), provides the rare opportunity for these small experiments to reach deep space destinations, as most launch opportunities for CubeSats are limited to low-Earth orbit.

"The 13 CubeSats that will fly to deep space as secondary payloads aboard SLS on EM-1 showcase the intersection of science and technology, and advance our journey to Mars," said NASA deputy Administrator Dava Newman in an earlier statement.

On this first flight, the SLS will launch the Orion spacecraft to a stable orbit beyond the moon to demonstrate the integrated system performance of Orion and the SLS rocket prior to the first crewed flight.

The CubeSats will be deployed following Orion separation from the upper stage and once Orion is a safe distance away.​

​New York, June 28 (IANS) A single oral dose of a drug that is already being used to treat a type of blood disorder could also improve our memory, suggests new research.

The researchers found that single dose of the common, inexpensive and safe chemical called methylene blue results in an increased response in brain areas that control short-term memory and attention.

Methylene blue is used to treat methemoglobinemia, a blood disorder in which oxygen is unable to release effectively to body tissues, and as a surgical stain.

"Although the memory-enhancing effects of methylene blue were shown in rodents in the 1970s, the underlying neuronal changes in the brain responsible for memory improvement and the effects of methylene blue on short-term memory and sustained-attention tasks have not been investigated," said study author Timothy Duong from University of Texas Health Science Center at San Antonio, Texas. 

"Our team decided to conduct the first multi-modal MRI study of methylene blue in humans," Duong noted.

Twenty-six healthy participants, between the ages of 22 and 62, were enrolled in a double-blinded, randomised, placebo-controlled clinical trial to measure the effects of methylene blue on the human brain during working-memory and sustained-attention tasks. 

The participants underwent functional MRI (fMRI) before and one hour after low-dose methylene blue or placebo administration to evaluate the potential effects of the compound on cerebrovascular reactivity during tasks. 

Mean cerebral blood flow was measured pre- and post-intervention.

The results showed methylene blue increased response in the bilateral insular cortex -- an area deep within the brain associated with emotional responses -- during a task that measured reaction time to a visual stimulus. 

The functional MRI results also showed an increased response during short-term memory tasks involving the brain's prefrontal cortex, which controls processing of memories, the parietal lobe, primarily associated with the processing of sensory information, and the occipital cortex, the visual processing centre of the brain. 

In addition, methylene blue was associated with a seven percent increase in correct responses during memory retrieval.

The study was published online in the journal Radiology.

The findings suggest that methylene blue can regulate certain brain networks related to sustained attention and short-term memory after a single oral low dose​

​New York, June 28 (IANS) Researchers including one of Indian-origin have created a new computer model that shows how tiny slits in the spleen prevent diseased red blood cells from re-entering the bloodstream.

Their model provides a new tool for studying the spleen's role in controlling diseases that affect the shape of red blood cells, such as malaria and sickle cell anaemia, and can be used to develop new diagnostics and therapeutics for a variety of acute and chronic diseases.

"The computational and analytical models from this work, along with a variety of experimental observations, point to a more detailed picture of how the physiology of human spleen likely influences several key geometrical characteristics of red blood cells," said Subra Suresh, President, Carnegie Mellon University in Pittsburgh, Pennsylvania, US.

The findings were published in the journal Proceedings of the National Academy of Sciences.

"They also offer better understanding of how the circulatory bottleneck for the red blood cell in the spleen could affect a variety of acute and chronic disease states arising from hereditary disorders, human cancers and infectious diseases, with implications for therapeutic interventions and drug efficacy assays." 

The spleen is like the water treatment plant for the body's bloodstream. It prevents pathogens from reaching the bloodstream and filters out old and misshapen red blood cells.

In order to "see" how the interendothelial slits regulate red blood cell circulation, the researchers created a computer simulation based on dissipative particle dynamics, a modeling method developed and refined for biological cells in partnership with Brown University Professor George Karniadakis. 

Their model allowed them to determine the range of cell sizes and shapes that could fit through the slits. 

The range closely mirrored the range of sizes and shapes for healthy red blood cells, indicating that only healthy cells should be able to pass through the slits.

In addition to giving researchers a better picture of how the spleen functions, the findings provide new insights into drug treatments. 

A class of drugs currently in development for treating malaria alters the shape of red blood cells infected with malaria, theoretically preventing them from passing through the interendothelial slit. 

The researchers' results also could explain why artemisinin-based anti-malarial drugs, which stiffen healthy and malaria-infected red blood cells, could lead to severe anaemia, the study said.​

​Beijing, June 26 (IANS) China will send its second orbiting space lab Tiangong-2 into space in mid September, said a senior official with the country's manned space programme.

The Shenzhou-11 manned spacecraft will be launched in mid September and its re-entry module will return in November, said Wu Ping, deputy director of the manned space engineering office, at a press conference on Saturday after the successful launch of the Long March-7, a new generation carrier rocket, at Wenchang, Hainan province.

As part of the country's space lab programme, the Shenzhou-11 spacecraft will carry two astronauts on board and dock with Tiangong-2.

The two astronauts have been chosen and currently under intense training, Wu said.

The Tiangong-2 and Shenzhou-11 will be carried by Long March-2F carrier rocket, she said.

In April 2017, the country's first cargo spaceship, Tianzhou-1, will be launched and carried by the Long March-7, Wu said.

"With the improvement of the rocket's technological performance, the Long March-7 will step by step replace the current carrier rockets and become the main carrier for space launches," she added.​

Kuala Lumpur, June 26 (IANS) Dried sewage sludge could be recycled by adding it to cement to make concrete, researchers in Malaysia have discovered.

Disposing sludge left over from treating sewage water is a major challenge for wastewater plants.

Meanwhile, the construction sector seeks economic and ecological cement replacement materials in order to meet an increasing demand for concrete.

Researchers from Universiti Teknologi MARA investigated the potential to replace various quantities of cement with processed sewage sludge to create a concrete mixture.

The researchers first produced domestic waste sludge powder (DWSP). They dried and burnt wet sludge cake to remove moisture, and then ground and sieved the dried sludge cake to make the sludge powder.

Using varying proportions of the powder, ranging from three-fifteen per cent, the researchers mixed the material with cement to produce normal strength and two higher strength grades of concrete.

They then compared the domestic waste sludge powder concrete mixture of each proportion with normal concrete in terms of their compressive strength, water absorption, water permeability and permeability to salt.

Overall, the researchers found that while domestic waste sludge powder has a potential role in the manufacture of concrete, the performance of the concrete blends tends to decline with increasing concentrations of the powder.

The findings were published in the Pertanika Journal of Science and Technology.

"Overall, there is potential for using DWSP as a partial cement replacement," the researchers said.

"However, more detailed research should be conducted to yield better quality powder," they added.​

​London, June 27 (IANS) Space-based detector can spot at least two gravitational waves -- ripples in space-time -- each year caused by collisions between supermassive black holes, revealing the initial mass of the seeds from which the first black holes grew 13 billion years ago.

A space-based instrument called the Evolved Laser Interferometer Space Antenna (eLISA) detector is set to be launched in 2034.

As eLISA will be in space - and will be at least 250,000 times larger than detectors on Earth - it should be able to detect the much lower frequency gravitational waves caused by collisions between supermassive black holes that are up to a million times the mass of our sun.

Scientists led by Durham University's Institute for Computational Cosmology ran the huge cosmological simulations that can be used to predict the rate at which gravitational waves caused by collisions between the monster black holes might be detected.

The study combined simulations from the EAGLE project - which aims to create a realistic simulation of the known Universe inside a computer - with a model to calculate gravitational wave signals.

“Understanding more about gravitational waves means that we can study the universe in an entirely different way. These waves are caused by massive collisions between objects with a mass far greater than our Sun," said lead author Jaime Salcido, PhD student in Durham University.

"By combining the detection of gravitational waves with simulations we could ultimately work out when and how the first seeds of supermassive black holes formed,” Salcido added.

In February, the international LIGO and Virgo collaborations announced that they had detected gravitational waves for the first time using ground-based instruments and in June reported a second detection.

Current theories suggest that the seeds of these black holes were the result of either the growth and collapse of the first generation of stars in the Universe; collisions between stars in dense stellar clusters; or the direct collapse of extremely massive stars in the early Universe.

As each of these theories predicts different initial masses for the seeds of supermassive black hole seeds, the collisions would produce different gravitational wave signals.

This means that the potential detections by eLISA could help pinpoint the mechanism that helped create supermassive black holes and when in the history of the Universe they formed.

“Black holes are fundamental to galaxy formation and are thought to sit at the centre of most galaxies, including our very own Milky Way,” noted co-author professor Richard Bower.

“Our research has shown how space-based detectors will provide new insights into the nature of supermassive black holes,” he added.

Gravitational waves were first predicted 100 years ago by Albert Einstein as part of his Theory of General Relativity.

The research was set to be presented at the Royal Astronomical Society's national astronomy meeting in Nottingham on Monday.​

Washington, June 24 (IANS) Researchers have developed a new technology that aims to make the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) even more sensitive to gravitational waves -- faint ripples in space-time.

The team from Massachusetts Institute of Technology (MIT) and Australian National University report on improvements to what is called a squeezed vacuum source. 

Although not part of the original Advanced LIGO design, injecting the new squeezed vacuum source into the LIGO detector could help double its sensitivity. 

This will allow detection of gravitational waves that are far weaker or that originate from farther away than is possible now.

“There are many processes in the universe that are inherently dark; they don't give off light of any colour,” said Nergis Mavalvala from MIT Kavli Institute for Astrophysics and Space Research. 

"Since many of those processes involve gravity, we want to observe the universe using gravity as a messenger,” Mavalvala said in a paper that appeared in the Optica. 

Scientists at Advanced LIGO announced the first-ever observation of gravitational waves earlier this year -- a century after Albert Einstein predicted their existence in his general theory of relativity. 

Studying gravitational waves can reveal important information about cataclysmic astrophysical events involving black holes and neutron stars.

Researchers from the California Institute of Technology and MIT conceived, built, and operate identical Advanced LIGO detectors in Livingston, Louisiana and Hanford, Washington. 

Each observatory uses a 2.5-mile-long optical device known as an interferometer to detect gravitational waves coming from distant events, such as the collision of two black holes detected last year.

The researchers are planning to add their new squeezed vacuum source to Advanced LIGO in the next year or so. 

Once implemented, it will improve the sensitivity of the gravitational detectors, particularly at the higher frequencies important for understanding the composition of neutron stars. 

These extremely dense stars contain the mass of the sun, which has a radius of 700,000 km, within just a 10-km diameter.​