Knowledge Update

New York, March 7 (IANS) Lungs tend to quickly lose their function outside the body. But this may soon change as researchers have found a method that could help maintain a fully functional lung outside the body for up to a week or even longer.

Lengthening the time to keep lungs functional outside the body could boost transplantation as a vast majority of donor lungs get rejected during transplantation due to delay in transport. It could also allow doctors to repair damaged donor lungs and make them suitable for transplant.

The research team found that "cross circulation" -- an abandoned surgical procedure used in the 1960s to exchange blood flow between two patients -- could enable long-term support of living organs outside the body by providing critical systemic and metabolic factors that are missing from all current technologies. 

Taking a cue from this procedure, the researchers developed a new technology to support fully functional lung outside the body for several days, according to a study published online in the journal Nature Biomedical Engineering.

"Our cross-circulation platform will likely allow us to extend the duration of support to a week or longer if needed, potentially enabling the recovery of severely damaged organs," said one of the lead researchers John O'Neill from Columbia University Medical Centre in the US. 

"Beyond prolonging support time, we also demonstrated several therapeutic interventions that vastly improve and accelerate recovery," O'Neill noted.

The researchers said that their new platform could be readily extended to recover other organs that are in high demand for transplant or in need of repair, including livers and kidneys, and they have already begun studies in these directions.

​Toronto, March 6 (IANS) Researchers have shown that synthetic DNA motors can work in living cells and help early detection of deadly diseases such as cancer and also make drug delivery more precise.

"This is really big because of the diverse potential applications," said one of the researchers Chris Le, Professor at University of Alberta in Canada.

"One outcome of this will be to provide better and earlier disease detection. Another is the controllable release of targeted drug molecules within patients, resulting in fewer side effects," Le said.

The process -- previously only successful in test tubes -- was described in a study published in the journal Nature Communications.

The team created the nanomachine from compartments made up of DNA enzyme molecules and substrates. 

"This nanomachine has the required fuels, DNA tracks, and a molecular switch," said Hongquan Zhang, Assistant Professor at University of Alberta, Canada.

For the study, it was 'tuned' to detect a specific microRNA sequence found in breast cancer cells. 

When it came into contact with the targetted molecules, the DNA motor was turned on and produced fluorescence as part of a reaction. 

The researchers were able to monitor the fluorescence, detecting which cells were cancerous. 

"We want to be able to detect cancer or disease markers in very minute amounts before the disease gets out of hand. That way physicians can attack it very early," Le said. 

"The trace amount of the target molecules that may be missed by other techniques can now be detected with this one," Le noted.

In addition to the potential for improved disease diagnosis, the researchers said DNA motors could also be used for precision drug delivery in patients. 

Conventional targetted drug therapy delivers medicine to a selectively targeted site of action, yet it still affects a large number of molecules that are not diseased. 

With the DNA motor, a drug payload can be delivered and then released only when triggered by disease specific molecules, the researchers said.

Rome, March 6 (IANS/AKI) The number of babies born in Italy hit a new historic low of 474,000 last year, 12,000 fewer than the 486,000 born in 2015, national statistics agency Istat said on Monday.

The total fertility rate fell to 1.34 children per woman in 2016 from 1.35 the previous year, while the average age at which women gave birth was nearly 32 (31.7 years), confirming the trend towards having children later, Istat data showed.

The drop in fertility "was due to the reduction of women of childbearing age (for national women) 
and to the aging process (for non national women)", Istat said.

Italy's population shrank to 60,579,000 in 2016, 86,000 less people than in the previous year, according to Istat figures.

A total of 134,000 more people died than were born in 2016, the second worse result ever, Istat said. 

There were more than 13.5 million people aged over 65 (22.3 percent of Italy's population) last year, 4.1 million over 80 and 17,000 people aged 100 and above, according to Istat.

Life expectancy rose in 2016 to 80.6 years for men and 85.1 years for women - a six-month increase for both sexes compared to last year, Istat figures showed.

New York, March 5 (IANS) Plants could be a renewable and biodegradable alternative to the polymers currently used in 3-D printing materials, researchers have found.

A new paper, published in the journal Advanced Materials Technologies, found that cellulose might become an abundant material to print with.

"Cellulose is the most important component in giving wood its mechanical properties. And because it is so inexpensive, it is biorenewable, biodegradable and also very chemically versatile, it is used in a lot of products," said Sebastian Pattinson, lead author of a paper, from Massachusetts Institute Of Technology (MIT).

"Cellulose and its derivatives are used in pharmaceuticals, medical devices, as food additives, building materials, clothing -- all sorts of different areas. And a lot of these kinds of products would benefit from the kind of customisation that additive manufacturing [3-D printing] enables," Pattinson added.

When heated, cellulose thermally decomposes before it becomes flowable, partly because of the hydrogen bonds that exist between the cellulose molecules. The intermolecular bonding also makes high-concentration cellulose solutions too viscous to easily extrude.

"We found that the strength and toughness of the parts we got... was greater than many commonly used materials for 3-D printing, including acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA)," he said.

Cellulose acetate is already widely available as a commodity product. In bulk, the material is comparable in price to that of thermoplastics used for injection molding and it's much less expensive than the typical filament materials used for 3-D printing.

​New York, March 5 (IANS) At a time when humans are generating more data than hard drives, scientists have demonstrated that a computer operating system and a short movie could be stored on a DNA.

In a new study, published in journal Science, a pair of researchers at Columbia University and the New York Genome Center (NYGC) showed that an algorithm designed for streaming video on a cellphone can unlock DNA's nearly full storage potential by squeezing more information into its four base nucleotides.

The researchers showed that their coding strategy packs 215 petabytes of data on a single gram of DNA, which study co-author Yaniv Erlich believe was the highest-density data-storage device ever created.

According to the team, DNA is an ideal storage medium because it is ultra-compact and can last hundreds of thousands of years if kept in a cool, dry place.

"DNA won't degrade over time like cassette tapes and CDs, and it won't become obsolete -- if it does, we have bigger problems," said Erlich.

Erlich and his colleague Dina Zielinski stored six files into a DNA -- a full computer operating system, an 1895 French film "Arrival of a train at La Ciotat", a $50 Amazon gift card, a computer virus, a Pioneer plaque and a 1948 study by information theorist Claude Shannon.

They compressed the files into a master file, and then split the data into short strings of binary code made up of ones and zeros.

Using an erasure-correcting algorithm called fountain codes, they randomly packaged the strings into so-called droplets and mapped the ones and zeros in each droplet to the four nucleotide bases in DNA.

They also demonstrated that a virtually unlimited number of copies of the files could be created with their coding technique by multiplying their DNA sample through polymerase chain reaction (PCR) and that those copies, and even copies of their copies, and so on, could be recovered error-free.

​New York, March 5 (IANS) While some people believe tanning makes them more beautiful, this habit can actually damage their skin in the long run, leading to wrinkles and sagging skin, says a study.

"Ultraviolet radiation from the sun and indoor tanning beds not only can increase your risk of skin cancer but also can contribute to skin ageing," said Arianne Shadi Kourosh from the Massachusetts General Hospital, Boston, US.

"Moreover, other forms of radiation, such as heat and visible light, can negatively impact the skin, as can pollution, so protecting your skin from the environment can benefit both your health and appearance," Kourosh said in a statement released by the American Academy of Dermatology.

Since both types of UV rays -- long wave ultraviolet A (UVA) and short wave ultraviolet B (UVB) -- can damage the skin, it is important to use a broad-spectrum sunscreen that provides both UVA and UVB protection, with an SPF (Sun Protection Factor) of 30 or higher, Kourosh said.

Environmental factors can damage the skin in multiple ways, from UVB rays causing sunburns and uneven pigmentation to UVA and infrared radiation penetrating more deeply into the skin to damage existing collagen and reduce collagen production, resulting in wrinkles and sagging skin, Kourosh said.

Habitual UV exposure can cause blood vessels to become more prominent, causing skin redness, while visible light and pollution can cause uneven skin tone, she said.

Washington, March 4 (IANS) The Hubble space telescope has captured an image to showcase an incredible massive galaxy, UGC 12591, that lies just under 400 million light-years away from the Earth.

The galaxy and its halo together contain several hundred billion times the mass of the Sun -- four times the mass of the Milky Way, NASA said in a statement on Friday.

It also whirls round extremely quickly, rotating at speeds of up to 1.8 million kilometers per hour, it added.

UGC 12591 sits somewhere between a lenticular and a spiral. 

It lies in the westernmost region of the Pisces-Perseus Supercluster, a long chain of galaxy clusters that stretches out for hundreds of light-years ? one of the largest known structures in the cosmos.

Observations with Hubble are helping astronomers to understand the mass of UGC 12591, and to determine whether the galaxy simply formed and grew slowly over time, or whether it might have grown unusually massive by colliding and merging with another large galaxy at some point in its past, NASA said.

The Hubble Space Telescope is a collaboration between NASA and European Space Agency (ESA).

London, March 4 (IANS) Eating foods rich in omega-3 fatty acids could significantly reduce damage caused by air pollution, suggests new research.

Omega-3 fatty acids (OFAs), found in a variety of foods including in oily fish, soy beans and spinach, could reduce inflammation and oxidative stress caused by air pollution by up to half, according to the study conducted in mice.

However, the research also shows air pollution particles can penetrate through the lungs of lab animals into many major organs, including the brain and testicles. This raises the possibility that the health damage caused by toxic air is even greater than currently known, The Guardian reported on Friday.

"I would definitely recommend taking OFAs to counter air pollution problems," lead researcher Jing Kang, at Massachusetts General Hospital, part of Harvard Medical School in the US, was quoted as saying.

"OFAs are well known to have many other healthy benefits and the key thing is they are not like a drug, but a nutrient with so many benefits," Kang said.

Two to four grammes per day would be the equivalent dose in humans to that given to the mice, Kang said.

The research suggests that omega-3 fatty acids could provide an immediate, practical solution for reducing the disease burden of air pollution.

London, March 4 (IANS) Researchers have discovered a new way of developing painkillers that act only on inflamed tissues, while keeping healthy ones unaffected, suggesting that the severe side effects currently associated with these medicines might be avoided.

When used in an animal model, their prototype of a morphine-like molecule was able to produce substantial pain relief in inflamed tissues without severe side effects, according to a study published in the journal Science.

The team of researchers used computational simulation to analyse interactions at opioid receptors -- the cell's docking sites for painkillers. 

"By analysing drug-opioid receptor interactions in damaged tissues, as opposed to healthy tissues, we were hoping to provide useful information for the design of new painkillers without harmful side effects," said Christoph Stein from Charite - Universitatsmedizin Berlin in Germany.

Opioids are a class of strong pain killers and are mainly used to treat pain associated with tissue damage and inflammation, such as that caused by surgery, nerve damage, arthritis or cancer. 

Common side effects associated with their use include drowsiness, nausea, constipation and dependency and, in some cases, respiratory arrest. 

In this study, the the researchers showed that they were able to analyse morphine-like molecules and their interactions with opioid receptors. 

They were able to successfully identify a new mechanism of action, which is capable of producing pain relief only in the desired target tissues -- those affected by inflammation.

The new findings could lead to treating postoperative and chronic inflammatory pain without causing side effects. 

Doing so would substantially improve patient quality of life.

Washington, March 2 (IANS) In a first, scientists have measured rapidly varying temperatures in hot gas emanating from around a black hole and found that the winds can heat up and cool down in the span of just a few hours.

The findings, published in the journal Nature, could shed new light on how winds emanating from around a black hole can affect the environment of host galaxies.

For the study, the researchers used data from NASA's Nuclear Spectroscopic Telescope Array (NuSTAR) telescope and the European Space Agency's XMM-Newton telescope. 

"We know that supermassive black holes affect the environment of their host galaxies, and powerful winds arising from near the black hole may be one means for them to do so," said NuSTAR Principal Investigator Fiona Harrison, Professor at California Institute of Technology in the US.

"The rapid variability, observed for the first time, is providing clues as to how these winds form and how much energy they may carry out into the galaxy," Harrison said.

The black hole that the researchers observed is located in the active galaxy IRAS 13224-3809 in the constellation Centaurus.

To measure the temperatures of these winds created by disks of matter surrounding black holes, the team studied X-rays coming from the edge of the black hole. 

As they travel toward Earth, these X-rays pass through the winds, and some wavelengths of the X-ray spectrum are absorbed by different elements in the winds, such as iron and magnesium. 

By examining the holes, or "absorption features", in the X-ray spectrum as it reaches Earth, astronomers can learn more about the components of the wind.

While observing this spectrum, the team noticed that the absorption features were disappearing and reappearing in the span of a few hours. 

The team concluded that the X-rays were actually heating up the winds to very high temperatures so that they became incapable of absorbing any more X-rays. 

The winds then cool off, and the absorption features return, starting the cycle over again.

"This is the first time we have seen that winds are interacting with the black hole's radiation," study first author Michael Parker, postdoctoral scholar at University of Cambridge Institute of Astronomy in Britain