Knowledge Update

Sydney, April 10 (IANS) A pioneering anaesthesia technique that makes surgery safer for patients with obstructed airways has helped save at least one life already, doctors in Australia said on Monday.

"An adult patient with an infected epiglottis was in danger of having his airway blocked by rapid swelling, and this technique enabled us to safely control his airway without surgery," said Anton Booth, Senior Lecturer at the University of Queensland in Brisbane, Australia.

"It is also making a difference to quality of life for those people who may previously have been unsuitable for surgery," Booth said in a university news release.

In a study conducted at Australia's Princess Alexandra Hospital, the team combined two relatively new techniques.

"Traditionally with anaesthesia we expect patients to stop breathing, as we are putting them into a state resembling a medically-induced coma," Booth said.

"Our job as anaesthetists is to take over breathing for the patient to keep them oxygenated, often through intubation. In patients undergoing surgery for narrowed airways we can't insert a tube into the trachea where the surgeons are trying to operate," he said.

"Instead we implemented a way to keep the patient breathing spontaneously during anaesthesia," Booth added.

The team supplemented that approach by adding high-flow nasal oxygen supply, previously used in intensive care and respiratory units.

"Through this combination we have been able to manage anaesthesia for patients with very challenging airway narrowing," he said.

"We have been able to achieve quite spectacular improvements in oxygen levels while patients are in deep anaesthesia. This is a modern alternative to traditional techniques and has great potential to be used in many other scenarios," Booth said.

The technique, known as STRIVE Hi, was detailed in the British Journal of Anaesthesia.

New York, April 10 (IANS) Just by looking at images of winter scenery and imagining yourself in such a setting can help you have increased cognitive control, say researchers.

Cognitive control is the ability to deliberately inhibit responses or make choices that maximise the long-term best interests of the individual. For example, when a person is very hungry and sees a sandwich but does not eat it, he/she is exhibiting cognitive control.

"Metaphorical phrases like 'coldly calculating', 'heated response' and 'cool-headed' actually have some scientific validity, which we demonstrate in our study," said lead researcher Idit Shalev from Ben-Gurion University of the Negev (BGU) in Israel. 

The findings, published in the journal Psychological Research, demonstrated that the perception of cold temperatures elicits greater cognitive control, even from a photo.

"Previous research focused on the actual effect of temperature on the psychological phenomenon known as 'cognitive control'," Shalev said. 

"But this is the first time we were able to measure the effects of perceived temperature," Shalev added.

In one of the experiments conducted for the study, 28 students were shown images of winter scenery, a temperature-neutral concrete street and a sunny landscape, and told to picture themselves in those settings.

The researchers then measured how the participants performed on an "anti-saccade task", an established cognitive control measure which requires looking in the direction opposite to which an object is moving.

"The result indicated that those viewing the cold landscape did better and that even without a physical trigger, cognitive control can be activated through conceptual processes alone," Shalev said.

The researchers said there is a possible explanation for the relation of temperature and cognitive control with social proximity. 

"While signals of warmth induce a relaxed attitude, cool signals trigger alertness and a possible need for greater cognitive control," Shalev explained.

​New York, April 8 (IANS) Researchers have discovered a protein that could help make vaccinations more effective and also provide protection from other diseases such as cancer.

The researchers purified a protein found on the exterior of bacteria (neisseria meningidis) and used it as an accessory to provide a better vaccination response. 

Typically, vaccines can either increase the amount of antibody production or they can stimulate cells (called cytotoxic T cells) to directly kill the offending agent. 

The protein, called PorB, is unique in that it can do both, the researchers said. 

The study, published online in the journal Scientific Reports, may lead to greater understanding of how vaccine enhancers work and can best be used.

"This study has wide implications as it could not only be used to help the body identify and fight off bacterial infections, but it could also potentially help the body use its own machinery to fight off other diseases like cancer, HIV, and influenza before they have a chance to establish within the body," explained corresponding author Lee Wetzler, Professor of Medicine and Microbiology at Boston University School of Medicine (BUSM) in the US.

In this study, the researchers used two experimental models. The first model was given a vaccination with antigen and mixed PorB, while the second model was given the antigen alone. 

The model that received the PorB had an increase in the response to the vaccine antigen, evidenced by an increased number of activated cells in the lymph nodes and a gain in the production of cytotoxic T cells, as compared to the vaccination with the antigen alone.

"Our study deepens the general understanding of how vaccine adjuvants modulate immune responses," Wetzler said.

"The antigen formulation with PorB triggers a sequence of cellular events at the periphery and in lymphoid tissue that are critical for the establishment of protection to a broad array of infectious diseases, and maybe for other diseases like cancer," Wetzler added.

​Washington, April 7 (IANS) NASA is preparing to launch on Saturday a super-pressure balloon about the size of a football stadium to carry a pioneering telescope designed to detect ultra-high-energy cosmic rays from near space.

The super pressure balloon (SPB) test flight is set to be launched from Wanaka Airport in New Zealand, on a potential 100-day journey.

If weather is conducive for launch, lift-off is scheduled between 8 and 11.30 a.m. locally, NASA said in a statement on Friday.

"At this time, the weather at the ground and lower levels looks very good for a Saturday launch attempt," said Gabe Garde, mission manager for the 2017 Wanaka Balloon Campaign.

"However, we continue to evaluate the forecast stratospheric winds and predicted flight trajectory to ensure conditions are acceptable before launch," Garde added.

The purpose of the flight is to test and validate the SPB technology with the goal of long-duration flight at mid-latitudes. 

In addition, the University of Chicago's Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB) is a mission of opportunity flying on the 2017 SPB test flight.

EUSO-SPB is designed to detect high-energy cosmic rays originating from outside our galaxy as they penetrate the Earth's atmosphere. 

As these high-energy particles enter the atmosphere, they interact with nitrogen molecules in the air and create a UV fluorescence light. 

EUSO-SPB will be looking downward at a broad swathe of the Earth's atmosphere to detect the UV fluorescence from these deep space cosmic rays coming in from above.

Once launched, the 532,000-cubic-metre balloon will ascend to an operational float altitude of 33.5 kilometres. 

NASA estimates the balloon will circumnavigate the globe about the southern hemisphere's mid-latitudes once every one to three weeks, depending on wind speeds in the stratosphere.

Toronto, April 7 (IANS) Having a furry friend at home may lead to reduced risk of allergy and obesity in children, suggests a new research.

Babies from families with pets -- usually dogs -- showed higher levels of two types of microbes associated with lower risks of allergic disease and obesity, according to the study published in the journal Microbiome.

"The abundance of these two bacteria were increased twofold when there was a pet in the house," said one of the study authors, Anita Kozyrskyj, from the University of Alberta in Canada.

The latest findings from Kozyrskyj and her team's work on fecal samples collected from infants registered in the Canadian Healthy Infant Longitudinal Development study build on two decades of research that show children who grow up with dogs have lower rates of asthma.

In the current study, the researcher found that exposure to pets in the womb or up to three months after birth increases the abundance of two bacteria, Ruminococcus and Oscillospira, which have been linked with reduced childhood allergies and obesity, respectively.

The pet exposure was shown to affect the gut microbiome indirectly -- from dog to mother to unborn baby -- during pregnancy as well as during the first three months of the baby's life. 

In other words, even if the dog had been given away for adoption just before the woman gave birth, the healthy microbiome exchange could still take place.

The study also showed that the immunity-boosting exchange occurred even in three birth scenarios known for reducing immunity - cesarean section versus vaginal delivery, antibiotics during birth and lack of breastfeeding.

New York, April 7 (IANS) Are you a night owl and have trouble getting up in the morning? It may be because your internal clock is genetically programmed to run slowly, researchers have found.

The findings showed that a mutation in a gene called CRY1 alters the human circadian clock, which dictates rhythmic behaviour such as sleep/wake cycles. 

People who are carriers of the gene variant experienced nighttime sleep delays of 2-2.5 hours compared to non-carriers, the researchers reported in the journal Cell.

"Carriers of the mutation have longer days than the planet gives them, so they are essentially playing catch-up for their entire lives," said lead author Alina Patke, from the Rockefeller University in New York City, US.

Night owls are often diagnosed at sleep clinics with delayed sleep phase disorder (DSPD) -- where a person's circadian ryhthm is delayed from the typical day/night cycle.

Mutation in CRY1 led to the development of DSPD, which affects up to 10 per cent of the population, according to clinical studies.

People with DSPD often struggle to fall asleep at night, and sometimes sleep comes so late that it fractures into a series of long naps. 

People with DSPD also have trouble conforming to societal expectations and morning work schedules, which leads to anxiety, depression, cardiovascular disease, and diabetes. 

The gene mutation was discovered while studying the skin cells of people with DSPD. 

The circadian clock responds to external environmental cues, so it is possible for people to manage the effects of the mutation on sleep. 

"An external cycle and good sleep hygiene can help force a slow-running clock to accommodate a 24-hour day," Patke said.

New Delhi, April 7 (IANS) As heart attacks continue to kill one person in every 33 seconds in India, health experts on Friday said that olive oil can help in decreasing cardio vascular diseases.

Olive oil is rich in MUFA or mono unsaturated fatty acids which helps in improving glycemic control and plasma lipid control and increase insulin sensitivity in diabetics and improve cardio vascular health, according to the experts.

The World Heath Organisation estimated that by 2020, cardiovascular disease will be the cause of over 40 per cent deaths in India as compared to 24 per cent in 1990.

"Olive oil contains a very important health benefiting element called oleic acid. It is known to be extremely heart-healthy and capable of fighting free radical damage (or oxidative stress), which has numerous health implications," said Nidhi Dhawan, head dietician at city based Saroj Superspecialty hospital. 

Dhawan said that due to the presence of powerful antioxidants known as polyphenols, olive oil is considered an anti-inflammatory food.

"It has been proven that olive oil is beneficial as it prevents strokes, keeps the heart young, fights osteoporosis, protects from depression, prevents skin and breast cancer," said Neelima Burra, Chief Marketing Officer of Cargill foods. 

The experts were speaking on the occasion of World Health Day.

Unlike other edible oils, olive oil contains about 75 per cent mono saturated fat which makes it the healthiest. 

Cargill food had earlier launched Leonardo Olive -- approved by the Food Safety and Standards Authority of India (FSSAI) -- keeping in mind the rising cases of cardio vascular and other diseases such as diabetes mellitus, chronic obstructive and pulmonary disease and cancer.

Stating that there was a rise in cardio vascular cases in rural India as well, Burra said that there is a need for the people of rural India to have more awareness about olive oil and its health benefits.

​London, April 7 (IANS) Imagine a milk carton sending you an alert on smartphone when its content is about to go out-of-date. This could soon be possible, thanks to the researchers who have fabricated for the first time printed transistors consisting entirely of two-dimensional nano-materials.

The team used standard printing techniques to combine graphene nano-sheets as the electrodes with two other nanomaterials, tungsten diselenide and boron nitride as the channel and separator (two important parts of a transistor) to form an all-printed, all-nano-sheet, working transistor.

This study, published in the journal Science, opens the path for industry, such as ICT and pharmaceutical, to cheaply print a host of electronic devices from solar cells to LEDs with applications from interactive smart food and drug labels to next-generation banknote security and e-passports, the researchers said.

The research could thus unlock the potential for applications such as food packaging that displays a digital countdown to warn you of spoiling, wine labels that alert you when your white wine is at its optimum temperature, or even a window pane that shows the day's forecast. 

"In the future, printed devices will be incorporated into even the most mundane objects such as labels, posters and packaging," said lead researcher Jonathan Coleman, an investigator in AMBER, the materials science research centre hosted in Trinity College, Dublin, Ireland.

"Printed electronic circuitry (constructed from the devices we have created) will allow consumer products to gather, process, display and transmit information: for example, milk cartons could send messages to your phone warning that the milk is about to go out-of-date," Coleman added. 

These 2D materials combine electronic properties with the potential for low-cost production. 

"We believe that 2D nano-materials can compete with the materials currently used for printed electronics. Compared to other materials employed in this field, our 2D nano-materials have the capability to yield more cost effective and higher performance printed devices," Coleman said.

The research shows that conducting, semiconducting and insulating 2D nano-materials can be combined together in complex devices. 

"We felt that it was critically important to focus on printing transistors as they are the electric switches at the heart of modern computing. We believe this work opens the way to print a whole host of devices solely from 2D nano-sheets," Coleman said.

​New York, April 6 (IANS) Eating potassium-rich foods like sweet potatoes, avocados, spinach, beans, bananas -- and even drinking coffee -- could be key to lowering blood pressure, new research suggests.

"Decreasing sodium intake is a well-established way to lower blood pressure, but evidence suggests that increasing dietary potassium may have an equally important effect on hypertension," said Alicia McDonough, Professor at the Keck School of Medicine of the University of Southern California (USC).

Hypertension is a global health issue that affects more than one billion people worldwide. The World Health Organization (WHO) estimates that hypertension is responsible for at least 51 per cent of deaths due to stroke and 45 per cent of deaths due to heart disease.

For the study, published in the American Journal of Physiology - Endocrinology and Metabolism, McDonough looked at population, interventional and molecular mechanism studies that investigated the effects of dietary sodium and potassium on hypertension.

The review found several population studies demonstrating that higher dietary potassium (estimated from urinary excretion or dietary recall) was associated with lower blood pressure, regardless of sodium intake. 

Interventional studies with potassium supplementation also suggested that potassium provides a direct benefit.

To understand the beneficial effects of potassium on hypertension, McDonough reviewed recent studies in rodent models.

These studies indicated that the body does a balancing act that uses sodium to maintain close control of potassium levels in the blood, which is critical to normal heart, nerve and muscle function.

"When dietary potassium is high, kidneys excrete more salt and water, which increases potassium excretion," McDonough said.

When dietary potassium is low, the balancing act uses sodium retention to hold onto the limited potassium, which is like eating a higher sodium diet, she said.

But how much dietary potassium should we consume? 

A 2004 Institute of Medicine report recommends that adults consume at least 4.7 grams of potassium per day to lower blood pressure, blunt the effects of dietary sodium and reduce the risks of kidney stones and bone loss, McDonough said.

​Tokyo, April 6 (IANS) Ever wondered why babies love and adore superheroes? It may be because they are born with a sense of justice -- a concept portrayed through the heroic acts of the characters, researchers say.

The findings showed that infants, as young as six months old, who can barely talk, are capable of recognising the heroic acts of justice and thus find themselves drawn to figures who protect the weak. 

This also explains why kids and adults alike have a never-ending love affair with superhero stories in popular culture, the researchers said.

"Six-month-old infants are still in an early developmental stage and most will not yet be able to talk. Nevertheless they can already understand the power dynamics between different characters, suggesting that recognising heroism is perhaps an innate ability," said David Butler from Kyoto University in Japan.

For the study, published in the journal Nature Human Behaviour, the team conducted a series of experiments where infants were shown animations of one geometric character chasing and bumping into another, as a third character watches from a distance. 

In one version, this third party character intervenes, and in another, it escapes in another direction. 

When the infants were then shown real life replicas of these intervening and non-intervening characters, they were more likely to choose the intervener, the researchers said.

"In human society, selflessly protecting the powerless is considered an act of heroic justice," added Yasuhiro Kanakogi from the Kyoto University. 

However, understanding these may be complex as one has to first grasp the power relationship between the actors, then understand that the hero's actions are favourable for the victim but not for the villain, and finally, that the hero acted deliberately, Kanakogi said.