Knowledge Update

​Moscow, Oct 27 (IANS) In a major step towards improving surgeries after head or face injuries, Russian scientists have developed a new type of 3-D-printed polymeric bone implants that can get absorbed and subsequently replaced with natural bone tissue in the body.

The prototype can be printed on 3D-printers according to specific parameters, contracted to half its size, then heated in the course of the surgery so the implant can obtain its original shape and size and is securely fixed in the section of the bone being restored. 

The implant is installed with a minimum number of metal fixators that are traditionally used in transplantation.

"We have successfully employed the shape memory effect of the lactic acid polymer - a composite based on polylactide. The porous composite structure is capable of shrinking to half its original size and then returning to its original shape," Project Manager Fyodor Senatov National University of Science and Technology MISIS in Moscow, said in a statement.

"This material is bioresorbable: it decomposes in the body without causing any harm," Senatov noted.

The researchers noted in traditional implant insertion after head injury, additional surgery is often required required due to the low rate of integration with the surrounding tissues or wrong implant position. 

The newly invented polymeric implant has a specified geometry and high porosity, and does not require any additional treatment, the researchers said. 

Due to the properties of the material and the use of the patient's own cells, it rapidly adapts and gets replaced with natural bone tissue. 

"Together with specialists at the N.N. Blokhin Russian Cancer Research Center, we have developed the technique of colonising the bioengineered structure with cells isolated from the patient's bone marrow," Senatov said,

"The preliminary colonization stimulates budding of blood vessels and tissues inside the implant, which optimises the process and increases the rate of integration with the surrounding tissues, making for more effective transplantation," Senatov said.

The developers plan to use the new implants in oral and maxillofacial surgery to replace small parts of skull bones, up to five cubic centimeters in size. 

The estimated cost of a bioengineered structure colonised with cells isolated from the patient's bone marrow is about $400, the researchers said.

​London, Oct 28 (IANS) Depending on lifestyle choices, taking vitamin E supplements for boosting immunity can have different effects on modifying the risk of pneumonia in older men, a study has found.

The study showed that vitamin E increased pneumonia risk by 68 per cent among men who had the highest exposure to smoking and who did not exercise.

Conversely, vitamin E actually decreased pneumonia risk by 69 per cent among participants who had the least exposure to smoking and who exercised during their leisure time. 

"The effect of vitamin E on health outcomes may depend on various characteristics of people and their lifestyle," said lead author Harri Hemila from the University of Helsinki, Finland. 

Therefore, a single universal estimate of the vitamin E effect might be substantially misleading for some population groups, Hemila said.

For the study, the team studied the effect of vitamin E on the risk of pneumonia on men aged 50 to 69 years old in Finland between 1985 and 1993. There were 898 cases of pneumonia among 29,133 participants of the study.

The author claims that these findings refute there being a uniform effect of vitamin E supplementation on the risk of pneumonia.

Given the current limited understanding about who might benefit, vitamin E should not be suggested for the general population for improving the immune system, Hemila recommended. 

The study was published in the British Journal of Nutrition.

Vatican City, Oct 26 (IANS/AKI) Fences are being erected in some countries to keep out migrants and refugees, but this only aids the criminal organisations who traffick human beings, Pope Francis said Wednesday.

"Today, the current economic crisis unfortunately fosters attitudes of closure instead of welcome," Francis told pilgrims at his weekly general audience in St Peter's Square. 

"In some parts of the world walls and barriers are being built. But this actually ends up favouring criminal trafficking," he stated.

The only solution to the phenomenon of migration is solidarity, Francis said.

"Solidarity with the migrant, solidarity with the 'foreigner'. It appears that the silent work of men and women who, in different ways, do what they can to help and assist refugees and migrants, is being drowned out by the noise made by those who give voice to an instinctive egoism." 

The growing influx of refugees fleeing war, famine and dire poverty requires Christians to welcome and care for them, as they have done through the ages, said Francis.

"Dioceses, parishes, religious institutes, organisations and individual Christians: we are all called to welcome our brothers and sisters who are fleeing war, hunger, violence and cruel conditions of life.

"As followers of Christ, may we never close our hearts to those in need."

New York, Oct 26 (IANS) Adding whole eggs to a colourful salad boosts the amount of vitamin E the body absorbs from the vegetables, says a study.

"We found vitamin E absorption was four- to seven-fold higher when three whole eggs were added to a salad," said Jung Eun Kim from Purdue University in West Lafayette, Indiana US.

"This study is novel because we measured the absorption of Vitamin E from real foods, rather than supplements, which contain mega-dose amounts of Vitamin E," Kim noted.

Vitamin E, which is absorbed along with dietary fats, is often found in oils, seeds and nuts.

Eggs, a nutrient-rich food containing essential amino acids, unsaturated fatty acids and B vitamins, also contain a small amount of vitamin E. 

This study accounted for how much total vitamin E was absorbed when vitamin E containing foods were co-consumed with whole eggs. 

This research supports a way to increase the absorption of vitamin E found in foods that contain low dietary fat. 

Also, this research highlights how one food can improve the nutrition value of another food when they are consumed together.

"Now consumers can easily improve their diets by adding eggs to a salad that boasts a variety of colourful vegetables," Wayne Campbell, Professor of Nutrition Science at Purdue University pointed out.

The findings were published in The Journal of Nutrition.

​Dhaka, Oct 26 (IANS) Bangladesh leads South Asia in gender equity, at world rank 72, followed by India at rank 87, in the Global Gender Gap Index 2016 prepared by the World Economic Forum. Pakistan figures at a lowly 143 in the ranking.

After India comes Sri Lanka, Nepal, the Maldives, Bhutan and Pakistan, in that order.

Iceland is ranked the first country in the Global Gender Gap Index of 144 countries.

According to the report, Bangladesh recorded progress in political empowerment gender gap, but its gap on women's labour force participation and estimated earned income widened.

The report found that the US fell from 28th place in 2015 to 45th when it came to closing the gap. The World Economic Forum (WEF) said that is primarily due to a more transparent measure for estimated earned income.

Through the Global Gender Gap Report, the WEF quantifies the magnitude of gender disparities and tracks their progress over time, with a specific focus on the relative gaps between women and men across four key areas: health, education, economy and politics.

​New York, Oct 26 (IANS) An experimental drug developed to combat Alzheimer's disease has the potential to prevent inflammation, remove abnormal protein clumps in the brain as well as restore memory in the patients suffering from the neurodegenerative disease, a study has found.

Development of abnormal protein clumps called amyloid plaques and tangled bundles of fibers in the brain -- key characteristic of Alzheimer's disease -- causes inflammation in the brain and damage to the neurons. This progressive damage leads to memory loss, confusion and dementia. 

The new drug, known as NTRX-07, appears to decrease this inflammation in the brain, while preserving neurons and regenerative cells in the brain, the study stated.

"This drug may reduce inflammation in the brain, which is linked to Alzheimer's disease," said lead researcher Mohamed Naguib, Professor at the Cleveland Clinic Lerner College of Medicine in Ohio, US. 

The new drug improved removal of abnormal amyloid plaques and improved memory performance and other cognitive skills.

"NTRX-07 uses a different mechanism than many other Alzheimer's drugs currently available, as it targets the cause of the disease, not just the symptoms," Naguib said.

In the study conducted on mice, NTRX-07 was found to target CB2 receptors -- receptors on the surface of microglia cells or immune cells that typically remove dangerous amyloid plaques in the brain. 

The mice treated with NTRX-07 also showed an increase in the levels of SOX2 -- protein that helps new brain cells to develop and protect the brain in people with Alzheimer's disease. 

In contrast, mice treated with a placebo showed decreased levels of SOX2, active inflammation in the brain, poor removal of amyloid plaques, and poor memory performance.

The study was presented at the ANESTHESIOLOGY 2016 annual meeting in Chicago, recently.

Washington, Oct 26 (IANS) Astronauts aboard the International Space Station have started planting their third on-orbit crop of red romaine lettuce, NASA said.

"Early this morning, NASA astronaut Shane Kimbrough initiated the Veg-03 experiment, one of his first science assignments as a new crew member aboard the orbiting laboratory," the US space agency said in a statement on Wednesday.

Astronomers are using a plant growth system called "Veggie" for their experiment.

The Veg-03 crop will be the Veggie team's first on-orbit attempt at a new, repetitive harvest technique termed ‘Cut-and-Come-Again'.

"Once the plants are approximately four weeks old, a selection of leaves can be harvested for a bit of fresh lettuce and possibly science samples. Meanwhile, some leaves are left intact along with the core of the plant, and will continue to grow and produce more leaves," explained said Nicole Dufour, NASA's Veggie project manager. 

"We expect this will increase the on-orbit crop yield, as well as allow for more opportunities to supplement our astronauts' diets with fresh, nutritious food from the same plants, which is an important goal of the ‘pick-and-eat' food concept," Dufour noted.

The team is anxiously awaiting germination results, expected early next week, Dufour said.

Astronauts on future long-duration space missions will need to be able to grow their own food to supplement their diets. 

Using the Veggie plant growth facility aboard the station, Veg-03 builds on the successes of previous studies, including Veg-01, which resulted in the first-ever on-orbit harvest and sampling of fresh produce during the summer of 2015. 

Techniques learned from Veggie crops will help NASA prepare for the Journey to Mars.

​Washington, Oct 26 (IANS) In good news for stroke and spinal cord injury patients, researchers have designed a lower-limb robot exoskeleton -- a wearable robot that features natural knee movement to help patients regain the ability to walk or help strengthen their muscles.

Researchers from Beihang University in China and Aalborg University in Denmark developed the wearable robot to greatly improve patients' comfort and willingness to wear it for gait rehabilitation.

The team's approach focused on the knee joint, one of the most complex mechanical systems within the human body and a critical player during gait.

The knee joint's motion is actuated by several skeletal muscles along its articular surfaces, and its center of rotation moves.

"Our new design features a parallel knee joint to improve the bio-imitability and adaptability of the exoskeleton," explained Weihai Chen, professor at Beihang University.

Movement transparency is critical when wearing a robot for gait rehab.

When wearing the exoskeleton, its movement should be synchronised and consistent with a patient's natural movement.

For this, the team focused on bionic mechanical design.

"To improve the transparency of the robot, we studied the structure of the human body, then built our model based on a biometric design of the lower limb exoskeleton," Chen said.

This design is the first known use of a parallel mechanism at the knee joint to imitate skeletal muscles.

As far as its applications, the exoskeleton's main role will be to help stroke or spinal cord injury patients with their rehab.

"We plan to streamline it to be wearable and to provide a comfortable training experience," Chen noted in the journal Review of Scientific Instruments.

The team is also developing virtual reality games to help make the training process more enjoyable.

The next step for the team is to collaborate with hospitals, because testing the robot out with patients can provide critical feedback from patients and doctors.

London, Oct 25 (IANS) A protein found in the blood of pregnant women could be used to develop tests to determine the health of their babies and aid decisions on early elective deliveries, a study reveals.

Low levels of the blood marker known as DLK1 can predict poor foetal growth and complications in pregnancy, and could be used as a non-invasive prenatal diagnostic, the study suggested.

"Measuring DLK1 levels in the mother's blood could be a reliable and non-invasive way of predicting whether there are likely to be complications, especially those that cause reduced nutrient supply to the baby," said Marika Charalambous, researcher at the Queen Mary University of London.

DLK1 is a protein that is found in high levels in the mother's blood during pregnancy, in humans and rodents. But little has been known about its source, what it does, and whether it can indicate anything about the health of a foetus.

The study published in the journal Nature Genetics initially used mice experiments that involved knocking out the gene in either the foetus or the mother, and then measuring the mother's DLK1 level to determine its source.

The researchers found that the protein originates from the embryo which means that its levels in maternal blood could provide a direct readout of the embryo's biological state.

The researchers studied 129 first-time mothers, taking measurements of DLK1 levels in their blood and recording the outcomes of their pregnancies. 

They found that low DLK1 levels were associated with reduced growth of the foetus resulting from pregnancy complications, including poor blood flow through the umbilical cord.

The team then looked at how DLK1 affects the metabolism of a pregnant mouse. When fasting for 24 hours, humans start a process known as 'ketosis', which is what the Atkins diet is based on, and involves burning the energy from fat stores to keep the body functioning.

When DLK1 was inactivated in pregnant mice, their fasting response was impaired by not being able to begin ketosis. This indicated the importance of DLK1 in providing energy for the foetus and their growth, and DLK1 levels in the mother were found to be a good predictor of the mass of their offspring.

​Sydney, Oct 25 (IANS) Increased muscle strength may help to improve brain function in adults who suffer from mild cognitive impairment (MCI), shows a new study.

MCI defines people who have reduced cognitive abilities such as reduced memory, but are still able to live independently. It is a precursor to Alzheimer's disease.

The findings published in the Journal of American Geriatrics show a positive causal link between muscle adaptations to progressive resistance training and the functioning of the brain among those over the age of 55 with MCI.

"What we found in this follow-up study is that the improvement in cognition function was related to their muscle strength gains. The stronger people became, the greater the benefit for their brain," said Yorgi Mavros, researcher at the University of Sydney, Australia.

The study participants were aged between 55 and 86 and were divided into four groups doing either: resistance exercise and computerised cognitive training; resistance exercise and a placebo computerised training (watching nature videos); brain training and a placebo exercise programme (seated stretching/calisthenics); or placebo physical exercise and placebo cognitive training.

Participants doing resistance exercise prescribed weight lifting sessions twice week for six months, working to at least 80 per cent of their peak strength. As they got stronger, the amount of weight they lifted on each machine was increased to maintain the intensity at 80 per cent of their peak strength.

The cognitive training and placebo activities did not have this benefit. The benefits persisted even 12 months after the supervised exercise sessions ended.

"The more we can get people doing resistance training like weight lifting, the more likely we are to have a healthier ageing population," Mavros added.

The study suggested that exercising frequently, at least twice a week and at a high intensity will give the maximum benefit for brain.