Knowledge Update

​New York, July 28 (IANS) More and more people are gradually viewing social media platforms like Facebook and Twitter and enterprise social media LinkedIn negatively than in the past, an interesting study has revealed.

London, July 28 (IANS) Online behavioural counselling tool can be effective at helping people lose weight, revealed a survey.

Using the Positive Online Weight Reduction (POWeR)+ online programme with very brief support from practice staff, participants lost over one kg more averaged over 12 months and were more likely to maintain clinically important weight loss by 12 months.

POWeR+ -- an online behavioural intervention -- is supported by brief contacts from a practice nurse. It teaches participants self-regulation and cognitive behavioural techniques to provide them with long-term, sustainable ways of forming healthy eating and exercise habits.

“Many people receiving the POWeR+ intervention were able to sustain weight loss over one year but also felt more enabled in managing their weight going forward, and fewer resorted to other activities such as commercial slimming programmes to lose weight," said Paul Little, Professor at University of Southampton in the study published in the journal The Lancet Diabetes and Endocrinology.

For the study, the researchers involved 818 people with a body mass index (BMI) over 30 who took part in 24 web-based sessions over six months.

They were randomly allocated to one of three groups - first, control - an existing online intervention that encourages healthier options. Second, POWeR+ with face-to-face support from a nurse, and third POWeR+ with remote very brief support from a nurse (on average three email contacts and one phone contact).

All patients were asked to come for appointments for weighing at six and also 12 months to see if weight loss was maintained.

They found that while people in all groups lost weight, the two groups receiving the POWeR+ intervention lost more.

The control group lost an average of three kg during 12 months and 21 per cent of people were able to maintain a clinically important amount of weight loss by 12 months.

The POWeR+ group with face-to-face support lost one and half kg more averaged over 12 months and 29 per cent of people had maintained important weight loss by 12 months.

The POWeR+ group with remote support lost 1.3kg more averaged over 12 months with 32 per cent able to maintain clinically important weight loss by 12 months.

Large patient numbers, limited staff training and time pressures mean that delivering face-to-face behavioural interventions in practice can be resource intensive, the survey suggested.​

​New York, July 27 (IANS) An infusion of stem cells harvested from a patient's own skin could help restore proper drainage for fluid-clogged eyes at risk of glaucoma, a study says.

When fluid accumulates in the eye, the increase in pressure could lead to glaucoma. The disease damages the optic nerve and can result in blindness.

The researchers injected stem cells into the eyes of mice with glaucoma. 

The influx of cells regenerated the tiny, delicate patch of tissue known as the trabecular meshwork, which serves as a drain for the eyes to avoid fluid buildup. 

"We believe that replacement of damaged or lost trabecular meshwork cells with healthy cells can lead to functional restoration following transplantation into glaucoma eyes," said lead researcher Markus Kuehn from University of Iowa in the US.

One potential advantage of the approach is that the type of stem cells used - called induced pluripotent stem cells - could be created from cells harvested from a patient's own skin. 

That gets around the ethical quandary of using fetal stem cells, and it also lessens the chance of the patient's body rejecting the transplanted cells.

Kuehn's team was able to get the stem cells to grow into cells like those of the trabecular meshwork by culturing them in a solution that had previously been "conditioned" by actual human trabecular meshwork cells.

The researchers were encouraged to see that the stem cell injection led to a proliferation of new endogenous cells within the trabecular meshwork. 

In other words, it appears the stem cells not only survived on their own, but coaxed the body into making more of its own cells within the eye, thus multiplying the therapeutic effect.

The team measured the effects in the mice nine weeks after the transplant. 

Laboratory mice generally live only two or three years, and nine weeks is roughly equal to about five or six years for humans.

The researchers say they are confident that their findings hold promise for the most common form of glaucoma, known as primary open angle glaucoma. They are not sure yet if their mouse model is as relevant for other forms of the disease.

The findings were published in the journal Proceedings of the National Academy of Sciences.​

​New York, July 26 (IANS) A new technology to coat fabric in self-healing, thin films may one day lead to chemically protective suits that may prevent farmers from exposure to pesticides, soldiers from chemical or biological attacks in the field and factory workers from accidental releases of toxic materials, say researchers.

"Fashion designers use natural fibres made of proteins like wool or silk that are expensive and they are not self-healing," said Melik Demirel, Professor at Pennsylvania State University in the US.

"We were looking for a way to make fabrics self-healing using conventional textiles. So we came up with this coating technology," Demirel said.

The procedure is simple. The material to be coated is dipped in a series of liquids to create layers of material to form a self-healing, polyelectrolyte layer-by-layer coating.

Polyelectrolyte coatings are made up of positively and negatively charged polymers.

This coating is deposited "under ambient conditions in safe solvents, such as water, at low cost using simple equipment amenable to scale-up," the researchers reported online in the journal ACS Applied Materials & Interfaces.

"We currently dip the whole garment to create the advanced material," Demirel said.

"But we could do the threads first, before manufacturing if we wanted to," he noted.

During the layering, enzymes can be incorporated into the coating. The researchers used urease -- the enzyme that breaks urea into ammonia and carbon dioxide -- but in commercial use, the coating would be tailored with enzymes matched to the chemical being targeted.

"If you need to use enzymes for biological or chemical effects, you can have an encapsulated enzyme with self-healing properties degrade the toxin before it reaches the skin," Demirel explained.

"The coatings are thin, less than a micron, so they wouldn't be noticed in everyday wear," Demirel said. 

For manufacturing environments where hazardous chemicals are necessary, clothing coated with the proper enzyme combination could protect against accidental chemical releases. 

The researchers believe that future use of these coatings in medical meshes could also help patients minimise infections for quick recovery.​

​New York, July 24 (IANS) Dietary changes in the US could feed significantly more people from existing agricultural land, suggests a new study that takes into account the per-person land requirements of different diets.

Using 10 different scenarios ranging from the average American diet to a purely vegan one, a team led by scientists from the Tufts University estimated that agricultural land in the contiguous US could have the capacity to feed up to 800 million people -- twice what can be supported based on current average diets.

The new "food-print" model, published recently in the journal Elementa, shows that a vegetarian diet that includes dairy products could feed the most people from the area of land available.

"Our approach challenges the 20th century emphasis on increasing yield and production. Improving crop yields remains vitally important, but it is not the only way to increase the number of people fed per acre. Our aim is to identify potential agricultural-sustainability strategies by addressing both food consumption and production," said lead author Christian Peters.

The researchers found that a lacto-vegetarian diet (a vegetarian diet that includes dairy products) had the highest carrying capacity, meaning that it could feed the most people from the area of land available.

Diets including some meat can feed more people than vegan diets, depending on estimates of how much land is suitable for crop cultivation, while the baseline diet had the lowest carrying capacity and required eight times more land than a vegan diet.

As the amount of meat in the diet was reduced between scenarios, the amount of land necessary for crops to feed livestock was also reduced.

"In our study, the estimates of carrying capacity for each diet are sensitive to assumptions about the area available for cultivated cropping. Furthermore, since most diet scenarios were consistent with the Dietary Guidelines for Americans, differences in carrying capacity should represent the trade-offs for food preferences rather than nutritional quality," Peters said.​

​Beijing, July 26 (IANS) Archaeologists have confirmed traces of ancient humans, dating back to over 10,000 years, at an altitude of 4,000 metres in China's Qinghai-Tibet plateau.

Hou Guangliang of Qinghai Normal University confirmed that the prehistoric ash layer discovered in 2013 is a residue of human activity, Xinhua news agency reported.

Dozens of stone tools were found at the same site, showing signs of civilisation in the plateau, making it the oldest evidence of human activity at over 4,000 metres.

The discovery is of great significance to research on how ancient humans coped in extreme environments, Hou said.

The plateau has an average altitude of 4,000 metres where winter temperatures can drop to -40 degrees Celsius.​

​London, July 28 (IANS) The impact of low physical capacity on risk of death is second only to smoking, a 45 year study in middle-aged men has found.

"The risk associated with low aerobic capacity was evident throughout more than four decades and suggests that being physically active can have a big impact over a lifetime," said lead author Per Ladenvall from Sahlgrenska Academy at the University of Gothenburg, Sweden. 

"The effect of aerobic capacity on risk of death was second only to smoking," Ladenvall noted.

The study included 792 men from a representative sample of 50-year-old men in Gothenburg recruited in 1963. 

In 1967, at 54 years of age, the men did an exercise test. Of those, 656 men also did a maximum exercise test in which they pushed themselves to the limit. 

The remaining men were excluded from the maximum exercise test because they had a health condition that could make it unsafe. 

Maximal oxygen uptake, called VO2 max, was measured in a sub-population of the 656 men using ergospirometry.

After the initial examination in 1967, the men were followed up until 2012, at the age of 100 years. Several physical examinations were performed, about one every 10 years. Data on all-cause death was obtained from the National Cause of Death Registry.

"We found that low aerobic capacity was associated with increased rates of death,” Ladenvall said.

The findings, published in the European Journal of Preventive Cardiology, showed that low physical capacity is a greater risk for death than high blood pressure or high cholesterol.

"We have come a long way in reducing smoking. The next major challenge is to keep us physically active and also to reduce physical inactivity, such as prolonged sitting," Ladenvall noted.​

New York, July 28 (IANS) Scientists have developed a new space boot with built-in sensors and tiny "haptic" motors whose vibrations can help astronauts avoid the risk of tripping over obstacles.

Falls in space can jeopardise astronauts' missions and even their lives. 

If an astronaut trips over moon rocks, getting to his or her feet in a bulky, pressurised spacesuit can consume time and precious oxygen reserves. Falls also increase the risk that the suit will be punctured. 

Since most falls happen because spacesuits limit astronauts' ability to both see and feel the terrain around them, reseachers from the Massachusetts Institute of Technology (MIT) developed the boot with built-in sensors to guide the wearer around or over obstacles.

"A lot of students in my lab are looking at this question of how you map wearable-sensor information to a visual display, or a tactile display, or an auditory display, in a way that can be understood by a nonexpert in sensor technologies," said Leia Stirling from MIT's Institute for Medical Engineering and Science.

"This initial pilot study allowed Alison [Gibson, a graduate student in AeroAstro and first author on the paper] to learn about how she could create a language for that mapping," Stirling added.

The team presented a prototype of the boot recently at the International Conference on Human-Computer Interaction in Toronto, Canada.

The work could also have applications in the design of navigation systems for the visually impaired. The development of such systems has been hampered by a lack of efficient and reliable means of communicating spatial information to users.​

London, July 28 (IANS) The “screen-and-treat” initiative for hepatitis B may reduce deadly complications of the virus, according to a new study.

The study, published in the journal The Lancet Global Health, suggested that the programme is cost effective and may be able to prevent complications of the disease.

To track hepatitis infection, the researchers ran a pilot study testing people for the virus in communities in Gambia, West Africa.

In the “screen and treat” programme, the researchers used a cheap instant test to screen around 6,000 people for the virus in the Gambian community and referred infected individuals for further liver tests and treatment. 

They also screened around 6000 blood samples from blood banks where some donor's blood was infected with hepatitis B. If an infected sample was detected, the researchers contacted the donor and referred them for tests and treatment.

“Hepatitis B is the leading cause of liver cancer and cirrhosis in Sub-Saharan Africa. Yet most patients do not realise they are infected until they develop severe symptoms,” said Maud Lemoine, researcher at the Imperial College London.

The new study found 9 per cent of individuals and 13 per cent of potential blood donors tested positive for the hepatitis B virus. However, of those screened only 4 per cent of the individuals tested were deemed to have infection severe enough to require treatment with antivirals.

The initiative also had a good screening coverage of 70 per cent, and the patients who required the antivirals kept to their medication schedule over the next year, suggested the study.

“Our study shows that screen-and-treat programmes targeting the general population are a feasible -- and successful -- intervention in Sub-Saharan Africa, and should be implemented in other areas in the continent," added Lemoine.

The hepatitis B virus infects around 250 million people worldwide and is transmitted through blood and bodily fluids. However the virus causes no immediate symptoms, and can remain silent in the body for decades until triggering severe complications such as liver damage (cirrhosis) and cancer.​

​New Delhi, July 26 (IANS) Chinese internet and technology conglomerate LeEco has launched a new video membership brand targeted at young consumers at the San Diego International Comic-Con (SDCC) held between July 21 and 24 at the San Diego Convention Centre in the US. The "Letv membership for Z-Generation" was launched on July 22 at an event hosted by famous talk show comedian Joe Wong. It aims to bring a wide range of online, offline and online-to-offline membership privileges and benefits, including free movie tickets, priority to buy movie and TV show merchandise, fan events, birthday package, production site visits, offline parties, movie previews, and participation in cast selection and crowdfunding. LeEco has entered into a strategic cooperation agreement with American film production/distribution studio Lionsgate to license content from its Comic-Con HQ streaming service, under which "Letv membership for Z-Generation subscribers" can view hours of exclusive content.​