Knowledge Update

New York, Nov 26 (IANS) US stocks rallied on Friday, with all three major indices refreshing closing records, as investors continued to digest the Federal Reserve's minutes from its November meeting.

Washington, Nov 25 (IANS) Researchers have found a novel way to make fuel cells more energy efficient and increase their power output by fine-tuning metal catalysts at the atomic scale.

A nano size squeeze can significantly boost the performance of platinum catalysts that help generate energy in fuel cells, according to the new study by scientists at Stanford University.

"Our tuning technique could make fuel cells more energy efficient and increase their power output," said study co-author Yi Cui, Professor at Stanford and SLAC National Accelerator Laboratory in California. 

"It could also improve the hydrogen-generation efficiency of water splitters and enhance the production of other fuels and chemicals," Cui noted.

The team bonded a platinum catalyst to a thin material that expands and contracts as electrons move in and out, and found that squeezing the platinum a fraction of a nanometre nearly doubled its catalytic activity. 

"In this study, we present a new way to fine-tune metal catalysts at the atomic scale," said lead author Haotian Wang, a former graduate student at Stanford now at Harvard University.

"We found that ordinary battery materials can be used to control the activity of platinum and possibly for many other metal catalysts," Wang noted.

The new technique described in the journal Science can be applied to a wide range of clean technologies, including fuel cells that use platinum catalysts to generate energy, and platinum electrolysers that split water into oxygen and hydrogen fuel, Wang said.

Catalysts are used to make chemical reactions go faster while consuming less energy. The performance of a metal catalyst depends on its electronic structure -- that is, how the electrons orbiting individual atoms are arranged.

The team introduced a novel way to compress or separate the atoms by 5 percent, a mere 0.01 nanometer.

"That might not seem like much, but it's really a lot," Cui said.

"We found that compression makes platinum much more active," Wang added. 

"We observed a 90 per cent enhancement in the ability of platinum to reduce oxygen in water. This could improve the efficiency of hydrogen fuel cells," Wang said.

New York, Nov 25 (IANS) Various brain regions that once synchronised their activity during memory tasks become smaller and lose cohesion as people age, says a study.

In the study, researchers from Princeton University in New Jersey, US, described a novel method to characterise and compare the brain dynamics of individual people.

The research showed that regardless of whether we were using memory, directing attention, or resting, the number of synchronous groups of connections within our brain was consistent. 

However, between different individuals, these numbers vary dramatically.

In fact, during memory specific actions, variations between people are closely linked to age.

Younger participants have only a few large synchronous groups that link nearly the entire brain in coordinated activity, while older participants show progressively more but smaller groups of connections.

In the older group this indicates loss of cohesive brain activity -- even in the absence of memory impairment, the authors noted.

"This method elegantly captures important differences between individual brains, which are often complex and difficult to describe," said Elizabeth Davison from Princeton University. 

"The resulting tools show promise for understanding how different brain characteristics are related to behaviour, health, and disease," Davison added.

For the study, the researchers used functional magnetic resonance imaging (fMRI) to record healthy people's brain activity during memory tasks, attention tasks, and at rest. 

For each person, the fMRI data was recast as a network composed of brain regions and the connections between them. 

The scientists then use this network to measure how closely different groups of connections changed together over time.

The study was published in the journal PLOS Computational Biology.

London, Nov 25 (IANS) Researchers have found that depression in young people is often followed by arthritis and diseases of the digestive system, while skin diseases are common after anxiety disorders.

The findings suggest that mental disorders are antecedent risk factors of certain physical diseases in early life, but also vice versa, according to the researchers.

"Our results expand the relevance of mental disorders beyond mental to physical health care, and vice versa, supporting the concept of a more integrated mental-physical health care approach, and open new starting points for early disease prevention and better treatments, with relevance for various medical disciplines," the study said.

The research group led by Marion Tegethoff in collaboration with Professor Gunther Meinlschmidt from the University of Basel in Switzerland examined the temporal pattern and relationship between physical diseases and mental disorders in children and young people. 

They analysed data from a representative sample of 6,483 teenagers from the US aged between 13 and 18.

The researchers noted that some physical diseases tend to occur more frequently in children and adolescents if they have previously suffered from certain mental disorders. 

Likewise, certain mental disorders tend to occur more frequently after the onset of particular physical diseases.

Affective disorders such as depression were frequently followed by arthritis and diseases of the digestive system, while the same relationship existed between anxiety disorders and skin diseases, showed the study published in the journal PLOS ONE.

Anxiety disorders were more common if the person had already suffered from heart disease. A close association was also established for the first time between epileptic disorders and subsequent eating disorders.

The results offer important insights into the causal relationship between mental disorders and physical diseases.

​New York, Nov 25 (IANS) Taking a step further in identifying a possible therapy for the Zika infection, researchers have discovered the mechanism by which a human antibody previously identified to react with the Dengue virus, prevents Zika infection at a cellular level.

Previously, the antibody C10 was identified as one of the most potent antibodies able to neutralise Zika infection. The new study, published in the journal Nature Communications, determines how C10 prevents the infection.

"By defining the structural basis for neutralization, these studies provide further support for the idea that this antibody will protect against Zika infection, potentially leading to a new therapy to treat this dreaded disease," said Ralph Baric, Professor at University of North Carolina.

To infect a cell, virus particles usually undergo two main steps, docking and fusion, which are also common targets for disruption when developing viral therapeutics. 

During docking, the virus particle identifies specific sites on the cell and binds to them. With Zika infection, docking then initiates the cell to take the virus in via an endosome -- a separate compartment within the cell body. 

Proteins within the virus coat undergo structural changes to fuse with the membrane of the endosome, thereby releasing the virus genome into the cell, and completing the fusion step of infection.

Using a method called cryoelectron microscopy, which allows for the visualisation of extremely small particles and their interactions, the team visualised C10 interacting with the Zika virus under different pHs (potential of hydrogen, a scale of acidity), so as to mimic the different environments both the antibody and virus will find themselves in throughout infection. 

They showed that C10 binds to the main protein that makes up the Zika virus coat, regardless of pH, and locks these proteins into place, preventing the structural changes required for the fusion step of infection. 

Without fusion of the virus to the endosome, viral DNA is prevented from entering the cell, and infection is thwarted.

"Hopefully, these results will further accelerate the development of C10 as a Zika therapy to combat its effects of microcephaly (a birth defect) and Guillain-Barre (paralysis) syndrome," one of the researchers Lok Shee-Mei from Duke-National University of Singapore Medical School in Singapore.

​Madrid, Nov 25 (IANS) World famous architect Norman Foster has been selected to renovate part of the famous Prado art gallery here, the museum has confirmed.

Foster will work with Spanish architect Carlos Rubio on the 30 million euro ($33 million) refurbishment of the 17th century Hall of Realms (Salon de Reinos in Spanish), Xinhua

​London, Nov 25 (IANS) Internet search mechanisms will need to change to support the Internet of Things (IoT) whereby billions of devices will become connected, say experts.

"Search engines have come a long way since their original purpose of locating documents, but they still lack the connection between social, physical and cyber data which will be

​New York, Nov 25 (IANS) Do you find it difficult to remember lessons despite reading them over and over again because of the stress that examinations put? If yes, this new study may provide you a solution. Researchers have found that learning by taking practice tests, a strategy known as retrieval practice, can protect memory against the negative effects of stress. "Our results suggest that it is not necessarily a matter of how much or how long someone studies, but how they study," said corresponding author on the study Amy Smith from Tufts University in Massachusetts, US. In experiments involving 120 student participants, individuals who learned a series of words and images by retrieval practice showed no impairment in memory after experiencing acute stress. Participants who used study practice, the conventional method of re-reading material to memorise it, remembered fewer items overall, particularly after stress, showed the study published in the journal Science. "Typically, people under stress are less effective at retrieving information from memory," said senior study author Ayanna Thomas, Associate Professor at Tufts University. "We now show for the first time that the right learning strategy, in this case retrieval practice or taking practice tests, results in such strong memory representations that even under high levels of stress, subjects are still able to access their memories," Thomas added. The research team asked participants to learn a set of 30 words and 30 images. These were introduced through a computer programme, which displayed one item at a time for a few seconds each. To simulate note taking, participants were given 10 seconds to type a sentence using the item immediately after seeing it. One group of participants then studied using retrieval practice, and took timed practice tests in which they freely recalled as many items as they could remember. The other group used study practice. For these participants, items were re-displayed on the computer screen, one at a time, for a few seconds each. Participants were given multiple timed periods to study. The researchers found that participants who learned through study practice remembered fewer words overall, and those who were stressed remembered even less. "Even though previous research has shown that retrieval practice is one of the best learning strategies available, we were still surprised at how effective it was for individuals under stress. It was as if stress had no effect on their memory," Smith said.

​New York, Nov 24 (IANS) Researchers have developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and connects wirelessly with a smartphone to measure the wearer's sweat to show how his or her body is responding to exercise.

Sweat is a rich, chemical broth containing a number of important chemical compounds with physiological health information, the researchers said.

The low-cost device, which is a little larger than a quarter and nearly the same thickness, connects wirelessly with a smartphone to analyse key biomarkers to help a person to find whether he/she needs to drink more water or energy drink to boost the electrolyte levels, or if something is medically going wrong in his/her body.

"The intimate skin interface created by this wearable, skin-like microfluidic system enables new measurement capabilities not possible with the kinds of absorbent pads and sponges currently used in sweat collection," said John A. Rogers, Professor at the Northwestern University, US.

For the study, published in the journal Science Translational Medicine, the team tested the device on two groups of cyclists. 

The device, which is designed for one-time use for a few hours, was placed directly on the skin of the forearm or back of the athletes.

It showed accurate accounts of the acidity of sweat and concentrations of glucose, chloride and lactate and could even detect the presence of a biomarker for cystic fibrosis.

To get the data, individuals had to use a smartphone to capture the photo of the device. An app then analyses that photo to display the relevant information.

"The sweat analysis platform we developed will allow people to monitor their health on the spot without the need for a blood sampling and with integrated electronics that do not require a battery but still enable wireless connection to a smartphone," said Yonggang Huang, Professor at the Northwestern University, US.

In the future, it may be more broadly used for disease diagnosis, the researchers added.

Melbourne, Nov 25 (IANS) An Australian Nobel Prize-winning scientist is developing a drug to counter allergies and asthma, a statement said on Friday.

Still in its initial stage the the drug can be taken as tablets, capsules, liquids or powder, Xinhua news reported. 

Barry Marshall, a microbiology professor from University of Western Australia, who won the Nobel Prize in Physiology in 2005 for stomach ulcer research, is working on the new drug.

The medication, named Immbalance, aims to suppress an overactive immune system.

"This actually arose from work we were doing on helicobacter, the stomach bug, for which Robin Warren and I won the Nobel Prize a few years ago," Marshall said on Friday.

"We've discovered the way it survives in your body is by suppressing the immune system so you can't get rid of it.

"I can't guarantee that it's going to cure allergy sufferers... we think this kind of thing will bring people who are hyper reactive... down into the normal range."

Marshall, who spent the last seven years developing the drug, said that it can be formulated as tablets, capsules, liquids or powder.

"Children could spread the powder on their cereal or put it in a drink and over the course of a few months could suppress their allergic response," he said in a UWA media release.

"We think it's going to be 100 percent safe. It won't remove your immune system; it will just take the edge off."