Knowledge Update

​New York, Feb 19 (IANS) Adult stem cells collected directly from human fat are more stable than other cells -- such as fibroblasts from the skin -- and have the potential for use in anti-ageing treatment, says a study.

Stem cells collected directly from human fat -- called adipose-derived stem cells (ASCs) -- can make more proteins than originally thought, showed the findings published in the journal Stem Cells.

"Our study shows these cells are very robust, even when they are collected from older patients," said the study's lead author Ivona Percec from Perelman School of Medicine at the University of Pennsylvania.

"It also shows these cells can be potentially used safely in the future, because they require minimal manipulation and maintenance," Percec said.

The researchers made the discovery after developing a new model to study chronological ageing of these cells.

Stem cells are currently used in a variety of anti-ageing treatments and are commonly collected from a variety of tissues.

But Percec's team specifically found ASCs to be more stable than other cells, a finding that can potentially open the door to new therapies for the prevention and treatment of aging-related diseases.

"Unlike other adult human stem cells, the rate at which these ASCs multiply stays consistent with age," Percec said.

"That means these cells could be far more stable and helpful as we continue to study natural aging," Percec noted.

London, Feb 19 (IANS) Researchers have developed hens that do not produce their own chicks and can be used as surrogates to lay eggs from rare breeds.

Using gene-editing techniques, this could help to boost breeding of endangered birds, as well as improving production of commercial hens, researchers wrote in the study published in the journal Development.

A team led by the University of Edinburgh's Roslin Institute used a genetic tool called TALEN to delete a section of chicken DNA. They targeted part of a gene called DDX4, which is crucial for bird fertility.

"These chickens are a first step in saving and protecting rare poultry breeds from loss in order to preserve future biodiversity of our poultry from both economic and climate stresses," said lead researcher Mike McGrew from the University of Edinburgh's Roslin Institute. 

Researchers noted that donor primordial germ cells from other breeds could be implanted into the gene-edited chickens as they are developing inside an egg. 

The surrogate hens would then grow up to produce eggs containing all of the genetic information from the donor breeds.

The surrogate chickens are the first gene-edited birds to be produced in Europe.

​San Francisco, Feb 19 (IANS) Researchers studying the brains of infants who have older siblings with autism were able to identify 80 per cent of the babies who would be subsequently diagnosed with autism at two years of age.

The results, published this week in the journal Nature, stem from research led by the University of North Carolina to use magnetic resonance imaging (MRI) to measure the brains of "low-risk" infants, with no family history of autism, and "high-risk" infants who had at least one autistic older sibling, Xinhua news agency reported.

A computer algorithm was then used to predict autism before clinically diagnosable behaviours set in, subsequently making it the first study to show that it is possible to use brain biomarkers to identify which infants in a high-risk pool, namely those having an older sibling with autism, will be diagnosed with autism spectrum disorder, or ASD, at 24 months of age.

"Typically, the earliest we can reliably diagnose autism in a child is age 2, when there are consistent behavioural symptoms, and due to health access disparities the average age of diagnosis in the US is actually age 4," said co-author and University of Washington (UW) professor of speech and hearing sciences Annette Estes. "But in our study, brain imaging biomarkers at 6 and 12 months were able to identify babies who would be later diagnosed with ASD."

While researchers at four clinical sites in the United States took part, the project included hundreds of children across the country.

The researchers obtained MRI scans of children while they were sleeping at 6, 12 and 24 months of age, and assessed the babies' behaviour and intellectual ability at each visit. 

They found that the babies who developed autism experienced a hyper-expansion of brain surface area from 6 to 12 months, as compared to babies who had an older sibling with autism but did not themselves show evidence of autism at 24 months of age. 

Increased surface area growth rate in the first year of life was linked to increased growth rate of brain volume in the second year of life. Brain overgrowth was tied to the emergence of autistic social deficits in the second year.

By inputting these data, including MRI calculations of brain volume, surface area, and cortical thickness at 6 and 12 months of age, into a computer program, the researchers sought to classify babies most likely to meet ASD criteria at 24 months of age. 

They found that, among infants with an older ASD sibling, the brain differences at 6 and 12 months of age successfully identified 80 per cent of those infants who would be clinically diagnosed with autism at 24 months of age.

The predictive power of the findings may lead to a diagnostic tool for ASD that could be used in the first year of life, before behavioural symptoms have emerged.

"We don't have such a tool yet," Estes was quoted as saying in a news release from UW. "But if we did, parents of high-risk infants wouldn't need to wait for a diagnosis of ASD at 2, 3 or even 4 years and researchers could start developing interventions to prevent these children from falling behind in social and communication skills ... By the time ASD is diagnosed at 2 to 4 years, often children have already fallen behind their peers in terms of social skills, communication and language."

​Los Angeles, Feb 19 (IANS) US space firm SpaceX on Sunday launched its 10th cargo mission to the International Space Station from US space agency NASA's historic moon pad for the first time.

NASA TV showed a Falcon 9 lifting off at 09.39 a.m. from US space agency NASA's historic Launch Complex 39A (LC-39A) at NASA's Kennedy Space Center in Florida for the first time, Xinhua news agency reported.

The launch is the first from LC-39A since the final flight of the space shuttle fleet in July 2011. LC-39A was best known as the launch site for the Apollo 11 mission, which sent the first humans to the surface of the moon, as well as numerous space shuttle missions.

About 8 minutes after launch, the California-based company successfully landed the first stage of its Falcon 9 rocket on ground again after launching commercial cargo to the International Space Station.

"Falcon 9 first stage has landed at LZ-1," SpaceX then tweeted.

On Saturday morning, SpaceX aborted the lift-off in the last minute due to a technical problem.

The rocket is being launched the company's Dragon spacecraft into orbit carrying about 5,500 pounds of equipment and experiments to the International Space Station.

It's the first SpaceX launch from Florida since a Falcon 9 exploded on the launch pad at Cape Canaveral Air Force Station on September 1, 2016.

Beijing, Feb 19 (IANS) A Chinese health alliance on Sunday agreed to promote the use of peak flow charts on both physical paper and smartphone apps to monitor the breath for children suffering from asthma.

The alliance is joined by the State Clinical Research Centre for Respiratory Diseases, Beijing Children's Hospital, Chinese Pediatric Society under Chinese Medical Association.

Professor Shen Kunling, head of the State Clinical Research Centre for Respiratory Diseases, said parents' knowledge, compliance with medicine instructions, and regular monitoring remain key to control childhood asthma.

Asthma is one of the most common chronic respiratory diseases for children. China has more than 6 million children with asthma. Nearly 30 per cent of them do not seek treatment in time and more than two thirds have reported asthma attacks.

​New York, Feb 18 (IANS) Photo-sharing mobile service Snapchat is reportedly planning to launch an Android smartphone that will give consumers more control over the camera features. "A California-based marketing firm has unveiled a concept handset equip with a 360-degree camera, buttons that let users scroll through filters and a one touch capture function for easy sharing," Daily Mail reported. The device might also inlcude a lock screen that allows users to easily swipe for Snapchat notifications and updates, messaging, and syncing with Spectacles. It may also pack Discover screen that combines GPS and maps, Snapchat Stories, and advertisements. Earlier this year, Snap Inc., parent company Snapchat, has made its long-awaited initial public offering (IPO) filing public, seeking to raise up to $3 billion. Snapchat aims to derive most of its revenue from advertising where it will compete against Google, Facebook and Twitter. Snap Inc. has recently rolled out major changes in its app that will make it easier to navigate the app with a universal search bar that's always accessible at the top of the app. Snapchat is also introducing "Our Story" -- a new global live story that any user can contribute to at any time.

​Beijing, Feb 18 (IANS) Chinese 4G users reached 770 million by the end of 2016, accounting for 58 per cent of all the country's mobile phone users, an official said here.

Zhang Feng, spokesperson and chief engineer for the Ministry of Industry and Informational Technology, on Friday said China has made great progress in the research and

Beijing, Feb 18 (IANS) China shipped 131.6 million smartphones in in the fourth quarter of 2016 with Huawei topping the list, followed by Oppo and Vivo, a new report said on Saturday.

​London, Feb 18 (IANS) For patients in the advanced stages of cancer, walking for at least 30 minutes thrice a week may boost a positive attitude towards their illness and improve their quality of life, new research claims.

Despite growing evidence of significant health benefits of exercise to cancer patients, physical activity commonly declines considerably during treatment and remains low afterwards.

"Walking is a free and accessible form of physical activity, and patients reported that it made a real difference to their quality of life," said lead researcher Jo Armes, a senior lecturer at London's King's College. 

The study is a first step towards exploring how walking can help people living with advanced stages of cancer. 

The findings in the programme of group walk for cancer patients showed marked improvement both physically, emotionally and psychologically.

"The study shows that exercise is valued by, suitable for, and beneficial to people with advanced cancer," said Emma Ream Professor at the University of Surrey in Britain.

Many participants noted that walking provided an improved positive attitude towards their illness and spoke of the social benefits of participating in group walks.

It also increased their motivation to reduce weight by altering diet, the researchers said, in the paper published in the journal BMJ Open.

For the study, the team included 42 cancer patients with advanced breast, prostate, gynaecological or haematological cancers.

They measured patient outcome after assessing quality of life, activity, fatigue, mood and self-efficacy that were completed at baseline of six, 12 and 24 weeks.

​New York, Feb 18 (IANS) Researchers have uncovered the mechanisms that the Zika virus uses to cause foetus microcephaly, a brain development disorder.

Babies with microcephaly can have a wide array of problems including a small brain and head, developmental delays, seizures, vision and hearing loss and feeding difficulty. 

While a Zika infection typically results in mild or symptom-free infections in healthy adults and children, the risk of microcephaly in the developing foetus is an alarming consequence that has created a worldwide health threat.

Since a normal brain develops from simple cells called stem cells that are able to develop into any one of various kinds of cells, the research team deduced that microcephaly is most likely linked with abnormal function of these cells.

Two weeks after the cells had developed into a certain type, the Zika infection was mainly found in glial cells, which provide support and insulation for the brain, according to the study published in the journal Stem Cell Reports.

There are currently 70 countries and territories reporting active Zika transmission, according to the World Health Organisation. 

There are two main lineages of the virus, African and Asian. 

Recently, the team found that only the Asian lineage has been linked with microcephaly. So, what is it about this particular form of the virus that inflicts such damage?

The researchers established a method of investigating how Zika alters the production, survival and maturation of brain stem cells using cells donated from three human foetal brains.

They focused on the impact of the Asian lineage Zika virus that was involved in the first outbreak in North America in late 2015.

"We discovered that the Asian lineage Zika virus halted the proliferation of brain stem cells and hindered their ability to develop into brain nerve cells," said study senior author Ping Wu, Professor at The University of Texas Medical Branch at Galveston in the US.

"However, the effect that the Zika virus had on the ability of stem cells to develop into specialized cells differed between donors. This difference seems to be linked with a Zika-induced change in global gene expression pattern, it remains to be seen which genes are responsible," Wu said.

"The unique system containing stem cells from three donors will allow us to dissect molecular mechanisms underlying Zika virus-induced brain malformation," Wu said.