Knowledge Update

​New York, Nov 8 (IANS) Researchers have identified a new way to block the action of genetic mutations found in nearly 30 per cent of all cancers.

Mutations in genes for the RAS family of proteins are present in nearly 90 per cent of pancreatic cancers and are also highly prevalent in colon cancer, lung cancer and melanoma, the most dangerous kind of skin cancer.

"We did not look for a drug or specifically for an inhibitor," said John O'Bryan, Associate Professor at University of Illinois College of Medicine in the US.

"We used monobody technology, a type of protein-engineering technology, to identify regions of RAS that are critical for its function," O'Bryan said.

Unlike conventional antibodies, monobodies are not dependent on their environment and can be readily used as genetically encoded inhibitors, O'Bryan said.

"The beauty of the technology is that when a monobody binds a protein, it usually works as an inhibitor of that protein," he said.

The prevalence of RAS mutations in human cancers and the dependence of tumors on RAS for survival has made a RAS a prime target for cancer research and drug discovery. 

Scientists and drug developers have long studied RAS oncogenes hoping to find a new treatment for cancer, but they have not yet been able to identify drugs that safely inhibit the oncogene's activity.

The researchers discovered that a synthetic binding protein they call "NS1 monobody," which they created in the lab, can block the activity of the RAS proteins.

The findings, published in the journal Nature Chemical Biology, provide important insight into long-standing questions about how RAS proteins function in cells. 

"Development of effective RAS inhibitors represents a 'holy grail' in cancer biology," O'Bryan said. 

"We now have a powerful tool we can use to further probe RAS function. While future studies and trials are needed before these findings can be leveraged outside the lab, this study provides new insight into how we can potentially inhibit RAS to slow tumour growth," he added.

Beijing, Nov 7 (IANS) China will have 58 million kilowatts (kw) of installed nuclear power by 2020 as it expands its clean energy network and pursues green growth, the country's energy regulator announced on Monday.

​New Delhi, Oct 21 (IANS) When Google launched artificial intelligence (AI)-powered premium devices Pixel and Pixel XL earlier this month, the message was clear: The device with the personal Google Assistant built right in sounded the threat bugle for Apple iPhone 7 and 7 Plus. The comparison is natural, especially in the absence of another flagship device, the Samsung Galaxy Note 7, which leaves Google and Apple fighting for the premium segment. Google has been synonymous with innovation. This time, with a brand new Android OS Nougat and Google Assistant, Pixel devices are set to counter Apple's iOS 10 and intelligent assistant Siri. Let us see what the 5.5-inch Pixel XL (32GB, black colour) has for Indian consumers who are searching for a premium smartphone. The aluminum and glass-built device looks elegant and fits comfortably in the palm. Unlike Nexus 6P, which had a thin glass strip at the top, Pixel XL's back panel has almost one-third glass covering. Putting an end to Android users' long wait, the Google Assistant in Pixel XL definitely has an edge over Apple's Siri. See for yourself. When asked, :Are you a man or a woman?", Google Assistant responded with answers like "I'm all inclusive :D" and "Does it really matter?" while Siri staidly replied: "I was not assigned a gender." To "Who will win the US presidential election?" Google Assistant displayed poll results by the New York Times, The Telegraph and Independent while Siri returned Wikipedia and Quora with an iOS 10-powered iPhone. While searching restaurants near our office, Google Assistant displayed food joints as close as 300 metres while Siri said that the nearest restaurant is 600 metres away. To further test its intelligence, Google Assistant was asked, "Who is Siri?" It explained, "Siri is Apple's intelligent assistant. She is very witty." Siri, however, was more informative than Google Assistant when asked "Who is the Prime Minister of India?". While Siri threw up results like when Narendra Modi became the Prime Minister and how long has he been serving, Google Assistant came back only with his name. Google Assistant can tell jokes, remember your passwords and even set the alarm for you in a clear voice. The "Pixel Imprint" fingerprint scanner is located at the back and is extremely responsive. It not only unlocked the device in a split second but also accepted (authorised) half a fingerprint for unlocking. While lock and volume up/down buttons are on the right of the Corning Gorilla Glass 4 protected AMOLED display, a nano-SIM slot sits at the left bumper of the device. Google has retained Type-C charging port that charged the 3,450 mAh battery in a flat 48 minutes. The device with Qualcomm's latest Snapdragon 821 Quad core processor and 4GB DDR4 RAM will get first updates and free unlimited cloud space is not to be missed. Google has put in a lot of accessories inside the box, including a two-way Type-C port cable ensuring OTG device (also included) support. With this cable, one can charge Pixel XL with another phone having a Type-C port. The smartphone runs like a charm on Android Nougat 7.1 -- the only device till date to have it. The apps explorer icon is replaced by a pull-up App Drawer which is more convenient. A swipe right on the screen brings the notable search results in line with browsing history. When we swiped right, information about the FC Barcelona vs Manchester City football match; updates about the Indian Soccer League tournament; and scores for the India vs New Zealand One-Day cricket match popped up. Pixel's 12.3MP rear camera with f/2.0 has been rated the highest ever 89 DxOMark Mobile score. It is very fast, responsive and has a video stabilising mode. As expected, the photos in broad daylight were stunning. Even in "very low light conditions", the camera did not disappoint. Under natural light at 7 pm, the photos clicked without flash had clarity and little grains while the photo taken with flash were sharper. As compared to shooting video in normal mode, we noticed a remarkable difference when we shot the same video with "Video Stabilisation" on. There were low or no jerks and no picture distortion. The 8MP camera works fine and while using it with Google's video calling app Duo, the receiver gets a sharper image (as compared to the Nexus 6P). One can even try new gestures, relish the audio output and save unlimited data online in original quality for free. What doesn't work? Pixel devices are not waterproof. At a time when Samsung Galaxy S7 Edge (and the now discontinued Galaxy Note 7) and Apple are offering IP68 rating (waterproof ratings), Pixel smartphones fall behind in this category. The camera does not have an optical image stabilisation feature and the Type-C to Type-C charging is slow. Conclusion: If you think about shelling out Rs 72,000 for the 32GB variant of iPhone 7 Plus, consider Google Pixel XL for Rs 67,000 as your date with Google Assistant will floor you without any doubt.

New York, Nov 7 (IANS) Struggling to shed those extra kilos? Worry not, as a new study suggests eating dinner early by mid-afternoon and following it by an 18-hour daily fast or until breakfast the next morning may help with losing weight.

The new research revealed that eating a very early dinner, or even skipping dinner, may reduce swings in hunger, alter fat and carbohydrate burning patterns, which may help in losing weight.

"The study found that eating between 8.00 a.m. and 2.00 p.m. followed by an 18-hour daily fast kept appetite levels more even throughout the day, in comparison to eating between 8.00 a.m. and 8.00 p.m.," said lead author Courtney Peterson from Pennington Biomedical Research Center in Louisiana, US.

"Eating only during a much smaller window of time than people are typically used to may help with weight loss," Peterson added.

The body has a internal clock, and many aspects of metabolism are at their optimal functioning in the morning.

Therefore, eating in alignment with the body's circadian clock by eating earlier in the day can positively influence health, the researchers explained.

The study showed that although the early time-restricted feeding (eTRF) strategy did not affect the amount of calories burnt by participants, it reduced daily hunger swings and increased fat burning during several hours at night.

It also improved metabolic flexibility, which is the body's ability to switch between burning carbs and fats. Whether eTRF helps with weight loss or improves other aspects of health is still unknown.

"These preliminary findings suggest for the first time in humans what we've seen in animal models -- that the timing of eating during the day does have an impact on our metabolism," said Dale Schoeller, Professor at the University of Wisconsin in Madison, US.

The findings were presented at The Obesity Society Annual Meeting at the ObesityWeek 2016 in Louisiana.

​New York, Nov 7 (IANS) Consuming sodium in the form of a dairy product, such as cheese, may protect against some of sodium's effects on the cardiovascular system, such as high blood pressure, researchers say.

According to researchers, the protection comes from antioxidant properties of dairy proteins in cheese.

The results suggest that when sodium is consumed in cheese it does not have the negative vascular effects that researchers observed with sodium from non-dairy sources.

"We found that when participants ate a lot of sodium in cheese, they had better blood vessel function -- more blood flow -- compared to when they ate an equal amount of sodium from non-dairy sources -- in this case, pretzels and soy cheese," said Anna Stanhewicz, post-doctoral fellow at the Pennsylvania State University.

"The novel finding may have implications for dietary recommendations. Newer dietary recommendations suggest limiting sodium, but our data suggest that eating sodium in the form of a dairy product, such as cheese, may be protective," added Lacy Alexander, Associate Professor at the Pennsylvania State University.

For the study, the researchers fed participants dairy cheese, pretzels or soy cheese on five separate occasions, three days apart.

They then compared the effects of each food on the cardiovascular system using a laser-Doppler, which shines a weak laser light onto the skin.

Further, the study revealed soy served as an additional control to match the fat, salt and protein content from a dietary source that is not dairy-based.

Participants who had more nitric oxide-moderated dilation after eating dairy cheese, compared to after eating pretzels or soy cheese, the researchers observed, in the paper reported in the British Journal of Nutrition.

​Sydney, Nov 7 (IANS) The year 2015, which is on record the hottest year globally, could become the new normal by 2040 if carbon emissions continue to rise at their current rate, researchers have warned.

However, with immediate and strong action on carbon emissions, it is still possible to prevent record-breaking seasons from becoming the new average -- at least at regional levels, the study said.

Only days ago, the historic Paris Agreement came into force, which aims to limit global warming to well below 2 degrees Celsius and as close to 1.5 degrees Celsius as possible to prevent dangerous tipping points in the climate system.

As of now, the Paris Climate Change Agreement has been joined by only 97 countries, including India, accounting for just over two-thirds of the world's greenhouse gas emissions.

According to lead author Sophie Lewis from the Australian National University (ANU), no matter what action we take, human activities have already locked in a "new normal" for global average temperatures that would occur not later than 2040.

"If we continue with business-as-usual emissions, extreme seasons will inevitably become the norm within decades and Australia will be the canary in the coal mine that will experience this change first," Lewis added.

For the study, using the National Computational Infrastructure supercomputer at ANU to run climate models, the researchers explored when new normal states would appear under the Intergovernmental Panel for Climate Change's four emissions pathways.

The ANU study coincides with the UN climate change conference in Marrakech, the first meeting of the Paris Agreement's governing body.

The Marrakech conference gives developed countries the opportunity to present their roadmap to mobilise the pledged $100 billion in annual support to developing countries by 2020.

The team of researchers also examined seasonal temperatures from December to February across Australia, Europe, Asia and North America.

The results revealed that while global average temperatures would inevitably enter a new normal under all emissions scenarios, this was not the case at seasonal and regional levels.

"It gives us hope to know that if we act quickly to reduce greenhouse gases, seasonal extremes might never enter a new normal state in the 21st Century at regional levels for the Southern Hemisphere summer and Northern Hemisphere winter," Lewis said, in the paper published in the Bulletin of American Meteorological Society.

New York, Nov 7 (IANS) Children born to mothers who were undernourished during pregnancy are more likely to suffer early ageing of the heart, a research has showed.

The animal study found that moderately reducing a mother's food intake can make it more likely that the baby's organs will show increased disease susceptibility and early ageing. 

These changes in the heart could contribute to decreased quality of life, decreased exercise capability, and increased vulnerability to other diseases such as diabetes and hypertension -- major risk factor for heart disease and stroke, the study said. 

Understanding the effect of maternal nutritional stress on ageing of the offspring will allow for interventions early in life, to prevent later-life heart problems, said a team of researchers led by Geoffrey Clarke from the University of Texas at San Antonio, US.

For the study, the team used MRI scanning to analyse the hearts of male and female baboons whose mothers ate 30 per cent less than the normally fed baboons. 

They found that the offspring of baboons, which ate less, showed signs of reduced heart function that comes with age. 

By five years of life, equivalent to 20 human years, the structure and function of the heart were already impaired.

"Women's health during pregnancy is of fundamental importance to the lifetime health of their babies. Society must pay attention to improving women's nutrition before and during pregnancy to prevent these adverse outcomes in babies," said Peter Nathanielsz, Director at the University of Wyoming in the US.

The study was published in The Journal of Physiology.

​Marrakesh (Morocco), Nov 7 (IANS) The Executive Secretary of the United Nations Framework Convention on Climate Change (UNFCCC), Patricia Espinosa, announced on Sunday that 100 parties formally joined the Paris Agreement on climate change.

​San Fransico, Nov 6 (IANS) A review of the way carbon offset credits have been used internationally to reduce carbon emissions suggests that the programme needs independent monitoring as it is now subject to inaccurate self-reporting.

​Dubai, Nov 6 (IANS) Two United Arab Emirates (UAE) companies announced on Saturday that they launched the first commercial-scale carbon capture, utilisation storage (CCUS) facility in the Middle East and North Africa.