Knowledge Update

​London, April 4 (IANS) The consumption of a paleolithic-type diet by obese women can help them lose weight and lower their future risk of diabetes and heart disease, says a new research.

A typical Paleolithic diet includes lean meat, fish, eggs, vegetables, fruits, nuts and berries, with rapeseed, olive oil and avocado as additional fat sources. It excludes dairy products, cereals, added salt and refined fats and sugar.

"Eating a Paleolithic-type diet without calorie restriction significantly improved the fatty acid profile associated with insulin sensitivity, and it reduced abdominal adiposity and body weight in obese postmenopausal women," said lead study author Caroline Blomquist, doctoral student at Umea University, Sweden. 

Also, the diet can improve fatty acid circulation especially in women who are in their postmenopausal phase and is likely to have long term beneficial effects on obesity-related disorders, including reduced risk for diabetes and cardiovascular disease.

The findings showed that saturated fatty acids decreased by 19 percent in women who consumed the Paleolithic-type diet.

Further, there was an increase of 47 percent in monounsaturated fatty acids and 71 percent increase was seen in their polyunsaturated fatty acids. 

Specific fatty acids associated with insulin resistance were found to be significantly lower in the women eating the Paleolithic-type foods compared with those on the prudent control diet.

The team conducted their 24-month intervention in 70 obese postmenopausal women with normal fasting plasma glucose levels. 

The women were randomly assigned to one of two groups. Those in the Paleolithic-type-diet group aimed to consume 30 percent of their total energy (E percent - energy percent) in protein, 30 E percent in carbohydrates, and 40 E percent in fats with high-unsaturated fatty acid content. 

In contrast, the women in the prudent control diet group aimed to eat 15 E percent in protein, 30 E percent in fat, and 55 E percent in carbohydrates.

The results were presented at the ENDO 2016, the annual meeting of the Endocrine Society, in Boston, US.​

​New York, April 4 (IANS) Testosterone therapy can help the elderly - suffering from low testosterone levels and pre-existing heart condition - reduce their risks of stroke, heart attacks and death, researchers report.

The study from the Intermountain Medical Center Heart Institute in Salt Lake City showed that patients who received testosterone as part of their follow-up treatment fared much better than patients who didn't.

Non-testosterone-therapy patients were 80 percent more likely to suffer an adverse event.

"The study shows that using testosterone replacement therapy to increase testosterone to normal levels in androgen-deficient men doesn't increase their risk of a serious heart attack or stroke,” said cardiologist Brent Muhlestein.

That was the case even in the highest-risk men -- those with known pre-existing heart disease.

The research team studied 755 male patients between the ages of 58 and 78 at Intermountain Medical Center who had severe coronary artery disease.

They were split into three different groups which received varied doses of testosterone administered either by injection or gel.

After one year, 64 patients who weren't taking testosterone supplements suffered major adverse cardiovascular events while only 12 who were taking medium doses of testosterone and nine who were taking high doses did.

After three years, 125 non-testosterone-therapy patients suffered major adverse cardiovascular events, while only 38 medium-dose and 22 high-dose patients did.

“Although this is an observational study, it does, however, substantiate the need for a randomised clinical trial that can confirm or refute the results,” Muhlestein noted.

The team presented the results at the American College of Cardiology's 65th annual scientific session in Chicago last weekend.​

New York, April 4 (IANS) Obese people struggling with weight loss can now opt for safe, minimally invasive, non-surgical weight-loss treatments, finds a new study.

Radiologists have developed a new image-guided treatment called bariatric arterial embolisation (BAE), which blocks blood flow to a certain part of the stomach that could help obese patients lose weight.

"Currently, interventions to treat obesity include behavioural modifications, diet and exercise, medications and surgery. We're excited about the promise of BAE as another tool for health care providers to offer patients in the effort to curb this epidemic," said Clifford Weiss, associate professor at Johns Hopkins University in US. 

The findings showed that compared to a surgical gastric bypass procedure, BAE is significantly less invasive and has a much shorter recovery time.

Though the results are still preliminary, BAE appears to be effective in helping patients lose a significant amount of weight in the short and intermediate term.

All patients demonstrated weight loss and dramatic hunger reduction levels after undergoing the treatment. 

The participants showed an average excess-weight loss of 5.9 percent, after a month. 

After six months, the excess-weight loss increased to an average of 13.3 percent.

The treatment starts by feeding a small catheter through a patient's arteries, via an incision in either the groin or the wrist, to an area at the top of the stomach called the fundus, where the hunger-stimulating hormone ghrelin is produced. Tiny beads are injected through the catheter to decrease blood flow to the fundus.

For the pilot study, the team enrolled seven severely obese, but otherwise healthy, adults with a body mass index (BMI) ranging from 40 to 60, far above the obesity threshold level of BMI of 30. 

After the treatment, researchers tracked the subjects' weight loss, ghrelin levels, hunger and satiety assessments, quality-of-life (using surveys), blood pressure, and adverse events at one-, three- and six-month marks.

In these first seven patients, bariatric embolisation was safe, with no major adverse events. There was weight loss and dramatic reduction in hunger levels. Also, ghrelin levels toned down and quality-of-life scores improved.

The study was presented at the ongoing Society of Interventional Radiology's 2016 Annual Scientific Meeting in Vancouver, Canada.

​New York, April 4 (IANS) Companies appear to structure compensation contracts and incentive pay based on seniors' personality traits and not just firm characteristics, a team of US researchers, including an Indian-origin scientist, has found.

Companies offer incentive-heavy compensation contracts to overconfident CEOs to "exploit" their positively biased views of the firms' prospects, the researchers noted.

"There are divergent views on the use of options and stock in CEO compensation contracts: Do they appropriately incentivise managers and enhance shareholder value and if so, why is there much variation in their use across firms?" said Vikram Nanda from Naveen Jindal School of Management in the US.

The notion is that if managers and shareholders -- represented by the board -- have a different take on a firm's prospects and CEO talent, there will be greater use of incentive pay that the managers value highly but the board regards as less costly.

"When you think about incentive contracts, you don't usually think about the personality of the individual being a factor in the contract," Nanda added in the paper published in the Journal of Financial Economics. 

Using the compensation data of CEOs between 1992 and 2011, the researchers identified managers who were exhibiting behaviour that was overconfident compared to other CEOs. 

"You don't usually hear about how two profit-sharing agreements are going to look different because the personalities and the beliefs of the individuals are coming into play," Nanda stated.

The team conducted empirical tests to explore the relationship between CEO overconfidence and incentive compensation.

The researchers found that CEO overconfidence increases the proportions of total compensation that comes from both option grants and equity grants, compared to other executives.

Overconfident CEOs receive even greater option and equity intensity in innovative and risky firms.

"Overconfident CEOs are prone to overestimate returns to investments and underestimate risks. They may use extremely positive words in the media or tend to invest more than a typical manager in the industry," Nanda stated.​

​Washington, April 2 (IANS) Hyundai Motor Co. and its smaller affiliate, Kia Motors Corp., have reported their best US performances in the first quarter of 2016, industry data showed. Combined with January and February sales, their performances marked the best ever for the first quarter, Yonhap cited the companies as saying on Friday. Hyundai's sales rose 0.4 percent to 75,310 units on the strong demand for the Tucson sport utility vehicle, whose sales rose 85 percent to 7,830 units from last year, as well as for the Sonata mid-size sedan whose sales rose 57 percent to an all-time high of 28,778 units, the company said. Kia's sales fell slightly to 58,279 units from last year's 58,771, but the company said the figure included the best-ever single month sales for the Forte line of compact cars, and together with January and February figures, marked a new first quarter record of 146,321 vehicles. The record was led by the Sportage sport utility vehicle, whose first-quarter sales rose 50 percent to 17,467 units from last year.​

Melbourne, April 1 (IANS) Annoyed by long selfie sticks in public? An Australian technology company has a solution -- a "selfie drone". This lets you click selfie without stretching the hand and gives you a perfect photo too. Built by Australian technology company IoT Group, the "ROAM-" drone opened for pre-sale on Thursday and will begin shipping internationally in June, Mashable website reported. According to Ian Duffell, executive director of the IoT Group, the company's vision was to build "a selfie stick on steroids". "The selfie stick's problem is it's confined by the length of the stick. The thought was, let's get the thing taking the picture flying with you," he was quoted as saying. After being tethered to a smartphone, the two rotor "ROAM-e" can be programmed using facial recognition technology to follow the user at a distance of up to 25 metres. The device can take 360-degree panoramas and can even stream a live video for up to 20 minutes of flight time. The $267 device has a 5-megapixel CMOS sensor camera and runs on Quadcore ARM Cortex A7 processor. Its rotors can be folded. "We wanted it to be small enough to fit into a bag or pocket. We modelled it on not being bigger than a 600-millilitre water bottle," Duffell explained. "We all know drones fly around and take pictures, but because we've tailored it to be portable and in your space, it fits into a different category," he said. IoT Group said they will an extra capability that is the ability of the drone to drop a pin on a map application, instructing the ROAM-e to travel to that point and return.​

San Jose, April 1 (IANS) Luxury electric car maker Tesla Motors, the facility of which Prime Minister Narendra Modi visited in Silicon Valley last year, has identified India as a market for one of its most affordable models that has a price tag of $35,000, said a top company official. "Adding several more countries to Model 3 order page tonight. Check for details, but will include India, Brazil, SA, SK, NZ, Sing (Singapore) & Ireland," Tesla Motor CEO Elon Musk said in a tweet. Unveiling the model's prototype on Thursday, Musk said the car would go into production in 2017. According to him, the car would accelerate from 0-60 kmph in less than 60 seconds and can go up to 345 km on a single charge. Musk said the car will be on sale by 2017-end and has a pre-order level of around 117,000 units. The company said once the production starts, deliveries will begin in North America. When the production is ramped up, deliveries in Europe, Asia-Pacific region and right-hand drive markets will happen. Last year, on September 27, Modi visited Tesla Motors facility. According to Musk, he and Modi talked about electricity generation and the way to skip ahead as it happened in the cell phones where it skipped ahead of landlines. Musk then said rural areas can have solar panels with battery packs which means there need not be electricity lines and skip ahead to next generation to power generation.​

New York, April 1 (IANS) Asia, the continent that houses roughly half the world's population, will face a "high risk of severe water stress" by 2050 if the current environmental, economical and population growth persists, warns a new study.

The study points out that water shortages are not simply the results of climate change and environmental stress. 

"It's not just a climate change issue. We simply cannot ignore that economic and population growth in society can have a very strong influence on our demand for resources and how we manage them," said one of the researchers Adam Schlosser, a senior research scientist at Massachusetts Institute of Technology (MIT) in US.

"And climate, on top of that, can lead to substantial magnifications to those stresses," Schlosser added.

The findings, published in the journal PLOS One, showed that the median amounts of projected growth and climate change in the next 35 years in Asia would lead to about 1 billion more people becoming "water-stressed" compared to the present time.

To conduct the study, the scientists built upon an existing model developed previously at MIT, the Integrated Global Systems Model (IGSM), which contains probabilistic projections of population growth, economic expansion, climate, and carbon emissions from human activity. 

They then linked the IGSM model to detailed models of water use for a large portion of Asia encompassing China, India, and many smaller nations.

The scientists then ran an extensive series of repeated projections using varying conditions. 

In what they call the "just growth" scenario, they held climate conditions constant and evaluated the effects of economic and population growth on the water supply. 

In an alternate "just climate" scenario, the scientists held growth constant and evaluated climate-change effects alone. And in a "climate and growth" scenario, they studied the impact of rising economic activity, growing populations, and climate change.

The study gave the researchers a "unique ability to tease out the human (economic) and environmental" factors leading to water shortages and to assess their relative significance, Schlosser said.

The IGSM model also allowed the team to look at how, under the same variables, scenarios change according to countries. This is particularly useful to come up with country-specific strategies, in order to avoid water stress.

"For China, it looks like industrial growth (has the greatest impact) as people get wealthier. In India, population growth has a huge effect. It varies by region," explained lead author Charle Fant, researcher at MIT.

Other variables, such as water supply networks into and out of the different areas, and the way population is distributed around said supplies should be examined, the researchers said. 

"We are assessing the extent to which climate mitigation and adaptation practices - such as more efficient irrigation technologies - can reduce the future risk of nations under high water stress," Schlosser said.​

Washington, April 1 (IANS) Delving deep into the heart of our Milky Way galaxy, NASA's Hubble Space Telescope has revealed a rich tapestry of more than half a million stars at its core.

Except for a few blue foreground stars, the stars are part of the Milky Way's nuclear star cluster - the most massive and densest star cluster in our galaxy. 

So packed with stars, it is equivalent to having a million suns crammed between us and our closest stellar neighbour Alpha Centauri. 

At the very hub of our galaxy, this star cluster surrounds the Milky Way's central supermassive black hole which is about four million times the mass of our sun.

Astronomers used Hubble's infrared vision to pierce through the dust in the disk of our galaxy that obscures the star cluster. 

Hubble's sharp vision allowed astronomers to measure the movements of the stars over four years. 

Using this information, scientists were able to infer important properties such as the mass and structure of the nuclear star cluster. 

The motion of the stars may also offer a glimpse into how the star cluster was formed -- whether it was built up over time by globular star clusters that happen to fall into the galaxy's centre, or from gas spiraling in from the Milky Way's disk to form stars at the core.

The picture, spanning 50 light-years across, is a mosaic stitched from nine separate images from Hubble's Wide Field Camera 3. 

The centre of the Milky Way is located 27,000 light-years away. 

Astronomers estimate that about 10 million stars in this cluster are too faint to be captured in this image.​

​London, April 1 (IANS) Forgetting can be the result of an active deletion process in the brain rather than a failure to remember -- a mechanism that helps us adapt our behaviour according to the surroundings, says a new study.

The findings could point towards new ways of tackling memory loss associated with conditions such as Alzheimer's disease and other types of dementia.

"Our study looks at the biological processes that happen in the brain when we forget something,” said Oliver Hardt from University of Edinburgh in Scotland.

"The next step is to work out why some memories survive whilst others are erased. If we can understand how these memories are protected, it could one-day lead to new therapies that stop or slow pathological memory loss," Hardt said.

The findings were published in The Journal of Neuroscience.

The study conducted in rats could also help scientists to understand why some unwanted memories are so long-lasting - such as those of people suffering from post-traumatic stress disorders.

Memories are maintained by chemical signalling between brain cells that relies on specialised receptors called AMPA receptors. 

The more AMPA receptors there are on the surface where brain cells connect, the stronger the memory.

The team found that the process of actively wiping memories happens when brain cells remove AMPA receptors from the connections between brain cells.

Over time, if the memory is not recalled, the AMPA receptors may fall in number and the memory is gradually erased.

Blocking the removal of AMPA receptors with a drug that keeps them at the surface of the cell stopped the natural forgetting of memories, the study found.​