Knowledge Update

​New York, May 18 (IANS) Love to binge on potatoes and French fries? If yes, you may be at an increased risk of developing high blood pressure, warns a new study.

Potatoes are one of the world's most commonly consumed foods -- and are a high source of potassium.

The findings showed that participants who consumed four or more than four servings a week of boiled, baked or mashed potatoes, are at an 11 percent increased risk of hypertension. 

Also, a higher consumption of French fries was associated with a 17 percent increased risk of hypertension in both women and men. 

However, consumption of potato chips (crisps) was associated with no increased risk.

In addition, potatoes have a high glycaemic index compared with other vegetables, thus it can also trigger a sharp rise in blood sugar levels.

"In the study, participants who did not have high blood pressure at baseline, and consumed four or more servings a week of potatoes (boiled, baked or mashed) later had a higher risk of developing hypertension compared to those who consumed one or less than one serving a month," said lead author Lea Borgi, physician at Brigham and Women's Hospital in the US. 

Replacing one serving a day of boiled, baked, or mashed potatoes with one serving of a non-starchy vegetable can lower the risk of developing hypertension, the researchers suggested.

For the study, published online in the British Medical Journal, the team followed over 187,000 men and women from three large US studies for more than 20 years. 

Dietary intake, including frequency of potato consumption, was assessed using a questionnaire.

The results "have potentially important public health ramifications, as they do not support a potential benefit from the inclusion of potatoes as vegetables in government food programs but instead support a harmful effect that is consistent with adverse effects of high carbohydrate intakes seen in controlled feeding studies," the researchers concluded.

​New York, May 18 (IANS) Intake of sesame rich food has many health benefits and the antioxidant boosting properties, especially sesame oil, can have a significant effect on oxidative stress, a new study has found.

After multiple clinical trials, researchers reported increased levels of antioxidants and a reduction in oxidative stress with sesame consumption, particularly for individuals with hypertension and with Type 2 diabetes.

Luciana de Almeida Vittori Gouveia and co-authors from Rio de Janeiro State University and Rio de Janeiro Federal University, Brazil, assessed the effects of consuming sesame-based ingredients on markers of oxidative stress in people with high blood pressure, elevated cholesterol and type 2 diabetes. 

The study was published in Journal of Medicinal Food.

"In addition to the clinical trial results reviewed in this article, preclinical studies have also shown that sesame oil is very effective in preventing atherosclerosis," said Sampath Parthasarathy from University of Central Florida.

The article effects of the intake of sesame seeds (Sesamm indicum L.) and derivatives on oxidative stress: A Systematic Review includes further discussion of the potential positive effects of sesame on different populations.​

​Washington, May 18 (IANS) Jupiter's moon Europa -- strongly believed to hide a deep ocean of salty liquid water beneath its icy shell -- can have the necessary balance of chemical energy for life even if the moon lacks volcanic hydrothermal activity, researchers have revealed.

Scientists at NASA's Jet Propulsion Laboratory (JPL), Pasadena, California, compared Europa's potential for producing hydrogen and oxygen with that of Earth through processes that do not directly involve volcanism.

The balance of these two elements is a key indicator of the energy available for life.

The study found that the amounts would be comparable in scale. On both worlds, oxygen production is about 10 times higher than hydrogen production.

The work draws attention to the ways that Europa's rocky interior may be much more complex and possibly Earth-like than people typically think.

“We're studying an alien ocean using methods developed to understand the movement of energy and nutrients in Earth's own systems. The cycling of oxygen and hydrogen in Europa's ocean will be a major driver for Europa's ocean chemistry and any life there, just it is on Earth,” explained Steve Vance, planetary scientist at JPL and lead author.

As part of the study, the researchers calculated how much hydrogen could potentially be produced in Europa's ocean as seawater reacts with rock in a process called serpentinisation.

In this process, water percolates into spaces between mineral grains and reacts with the rock to form new minerals, releasing hydrogen in the process.

New cracks expose fresh rock to seawater, where more hydrogen-producing reactions can take place.

In Earth's oceanic crust, such fractures are believed to penetrate to a depth of five-six kms.

On present-day Europa, the researchers expect water could reach as deep as 25 kms into the rocky interior, driving these key chemical reactions throughout a deeper fraction of Europa's seafloor.

The other half of Europa's chemical-energy-for-life equation would be provided by oxidants -- oxygen and other compounds that could react with the hydrogen -- being cycled into the Europan ocean from the icy surface above.

“The oxidants from the ice are like the positive terminal of a battery, and the chemicals from the seafloor, called reductants, are like the negative terminal," noted Kevin Hand, planetary scientist at JPL.

“Whether or not life and biological processes complete the circuit is part of what motivates our exploration of Europa,” he added in a new paper published in Geophysical Research Letters, a journal of the American Geophysical Union.

Europa's rocky, neighbouring Jovian moon “Io” is the most volcanically active body in the solar system.

Scientists have long considered it possible that Europa might also have volcanic activity, as well as hydrothermal vents, where mineral-laden hot water would emerge from the sea floor.

NASA is currently formulating a mission to explore Europa and investigate the moon's potential habitability.​

London, May 18 (IANS) Based on the "liquid wire" technique in spider webs, a team of international researchers has created composite fibers which extend like a solid and compress like a liquid.

Pulling on a sticky thread in a garden spider's orb web and letting it snap back reveals that the thread never sags but always stays taut, even when stretched to many times its original length.

This is because any loose thread is immediately spooled inside the tiny droplets of watery glue that coat and surround the core gossamer fibres of the web's capture spiral.

The study, which was carried out by researchers from the University of Oxford and the Pierre and Marie Curie University, Paris, was published by the University of Oxford in the journal Proceedings of the National Academy of Sciences.

"Surprisingly, each drop packs enough punch in its watery skins to reel in loose bits of thread. And this winching behaviour is used to excellent effect to keep the threads tight at all times, as we can all observe and test in the webs in our gardens," said Prof. Fritz Vollrath form the University of Oxford.

The novel properties observed and analysed by the researchers rely on a subtle balance between fibre elasticity and droplet surface tension. The team was also able to recreate this technique in the laboratory using oil droplets on a plastic filament.

This artificial system behaved just like the spider's natural winch silk, with spools of filament reeling and unreeling inside the oil droplets as the thread extended and contracted, according to the study.

"Our bio-inspired hybrid threads could be manufactured from virtually any components. These new insights could lead to a wide range of applications, such as micro-fabrication of complex structures, reversible micro-motors, or self-tensioned stretchable systems," said Herve Elettro, the first author of the study and a doctoral researcher from the Pierre and Marie Curie University.​

​London, May 18 (IANS) A study has found a new link between inflammation and cell division -- two of the most important processes in the human body whose accurate control is a holy grail for scientists researching the prevention of infection, inflammatory disease and cancer.

"This is an exciting discovery: for the first time we find a link between the system which regulates how cells divide and the basis of some of medicine's most intractable diseases," said Mike White, who led the joint study by the University of Manchester and Liverpool. 

Inflammatory signals produced by a wound or during an infection can activate a protein called Nuclear Factor-kappaB (NF-kB), which controls the activity of genes that allow cells to adapt to the situation.

Incorrect control of NF-kB is associated with inflammatory diseases, such as Crohn's disease, psoriasis and rheumatoid arthritis. It has also been linked with ageing and some cancers.

A key way in which human cells adapt to signals in their environment is by dividing to produce new cells through a repeating pattern of events, called the cell cycle. A cell first makes copies of its DNA, in a stage known as the DNA synthesis phase, and then divides into two daughter cells.

The cell cycle is controlled by a family of proteins called E2 factors, which control the start of the new cell's DNA synthesis phase.

The study published recently in the journal eLife showed that the NF-kB and E2 factors bind to each other in the cell. This controls the level of the NF--kB signal, which is enhanced just before DNA synthesis, but reduced during the DNA synthesis phase.

Scientists also showed that signals which activate NF-kB can change the timing of cell division.

The findings suggest that direct interactions between E2 factor proteins and NF-kB enable cells to decide whether to divide and determine how they react in different ways to inflammatory signals.​

New York, May 18 (IANS) A skull condition that has been believed to be a thing of the past due to poor diet among our ancestors not only still exists, but is fairly common among modern humans, new research has found.

The skull condition called cribra orbitalia (CO) makes bone inside the eye sockets porous. It is not known to cause any adverse health effects, but is generally regarded as being caused by iron deficiency anemia.

The condition has traditionally been used by anthropologists to assess diet and health in prehistoric populations. 

For example, the presence of CO could tell researchers that a population was not getting a sufficiently varied diet.

"But there's been a lot of debate about the prevalence of CO in modern populations, with some saying it had effectively disappeared," said study co-author Ann Ross from North Carolina State University in the US.

"We wanted to know if CO was still extant and, if so, how common it is in modern populations, relative to earlier eras," Ross noted.

For this study, the researchers looked at modern, historic and prehistoric human remains from South Africa, North America.

Altogether, the researchers evaluated data on 844 skulls -- 245 prehistoric, 381 historic (as recent as the early 20th century) and 218 modern.

The researchers found that CO was not only present in modern populations, but that it was not even uncommon.

For example, the researchers found that two of the five modern North American juvenile skulls evaluated in the study - 40 percent - had CO. And 15 of the 60 South African juveniles evaluated in the study - 25 percent - had CO.

Overall, the researchers found that 12.35 percent of modern North Americans and 16.8 percent of modern South Africans, across all age groups, had CO.

Both rates are higher than their historic counterparts. Only 2.23 percent of historic South African skulls evaluated had CO, and only 6.25 percent of historic North American skulls. Even the prehistoric North American skulls had a lower rate of CO, at 11.86 percent.

The study was published online in the journal Clinical Anatomy.

"We think the increased prevalence of CO in the modern skulls may be due to intestinal parasites in some populations and iron-poor diet," Ross noted.

"These findings drive home the fact that disadvantaged socioeconomic groups, and parts of the developing world, are still struggling with access to adequate nutrition," Ross added.​

​Beijing, May 18 (IANS) The number of registered museums in China has reached nearly 4,700, with more than 85 percent of them free to visit, a national cultural official said on Wednesday.

By the end of 2015, 4,692 museums were registered and more than 20,000 exhibitions were held annually, drawing 700 million visitors, Xinhua news agency quoted Liu Yuzhu, head of the State Administration of Cultural Heritage, as saying.

"As public cultural services, museums are significant in displaying civilisation, boosting cultural exchanges and improving morality, science and culture," Liu said.​

​Toronto, May 17 (IANS) Children and young adults take a long time to fully recover from any brain injury occurring while playing games, says a study.

The findings of the Canadian study indicate that those in the age group of eight to 16 are not only vulnerable to concussions but -- because their brain is still developing -- they are neurologically more fragile than adults for performing tasks that require cognitive motor integration following a concussion.

After a concussion, young athletes usually rejoin their teams in a few weeks if they do not have any active symptoms. 

“However, they may take up to two years to fully recover from the injury before they can play as skillfully as their teammates with no history of concussion," said Lauren Sergio from York University in Canada.

"Performing motor tasks, guided by what we see, is crucial in skill-based activities such as sports," Sergio added in the paper published in the journal Concussion. 

The team analysed the prolonged difficulty in cognitive-motor integration in 50 children and adolescents with a history of concussion and were compared with 49 who have never had a concussion.

The participants in both the groups were asked to perform two different tasks on a dual-touchscreen laptop. 

In one task, target location and motor action were aligned. In the other task that tested cognitive-motor integration, the required movement was not aligned with the guiding visual target and required simultaneous thinking for successful performance.

"We noticed significant difficulty in completing the tasks among those with concussion history," said lead author Marc Dalecki.

"In fact, it took many of the children two years after the concussion to have a similar performance on the task as children who did not have a history of concussion," Dalecki noted.

"The current return to sport assessment doesn't test to see if the injured person has regained this ability. Because of this, often children and youth who have had a concussion end up returning to normal activities before they are fully recovered which makes them more vulnerable to another concussion," Sergio said.​

London, May 17 (IANS) Germs could play a role in the development of Type-1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, suggests new research.

Type-1 diabetes is a very serious and hard to treat condition affecting mainly young people and children.

Previous research has shown that killer T-cells -- a type of white blood cell that normally protects us from germs -- play a major part in type-1 diabetes by destroying insulin producing cells, known as beta cells.

"The study identified part of a bug that turns on killer T-cells so they latch onto beta cells. This finding sheds new light on how these killer T-cells are turned into rogues, leading to the development of type-1 diabetes," said lead author Andy Sewell, professor at Cardiff University in Britain.

These killer T-cells are strongly activated by some bacteria.

During type-1 diabetes, the T-cells attack pancreatic beta cells -- which make the insulin essential for control of blood sugar levels.

When beta cells are destroyed, patients have to inject insulin every day to remain healthy.

"Killer T-cells are extremely effective at killing off germs, but when they mistakenly attack our own tissues, the effects can be devastating," Sewell said.

The research, published in the Journal of Clinical Investigation, provides a first ever glimpse of how germs might trigger killer T-cells to cause type-1 diabetes, but also points towards a more general mechanism for the cause of other autoimmune diseases.

"Finding the cellular mechanisms behind the development of autoimmune diseases, such as type-1 diabetes, could lead to treatments that help us lead longer, healthier lives," David Cole from Cardiff University noted.​

New Delhi, May 17 (IANS) South Asians number the highest among patients suffering from hypertension, doctors said on Tuesday. Hypertension leads to conditions like brain stroke and heart attacks, among others, and regular medication and check-up is needed to control it.

According to the doctors, the factors triggering hypertension among the South Asians include stress and the poor habits of taking 'gutka', 'kimam', 'paan' or 'naswar'.

"Studies show that stroke-related deaths are higher among the South Asian people than the White people, all because of hypertension. We South Asians develop high blood pressure, diabetes or high cholesterol much more easily in comparison to the people of West," said Vipul Gupta, head of Neurovascular Intervention Centre at Medanta.

Noting that hypertension is the prime reason behind heart and brain strokes, Gupta said because of ignorance the condition reaches a stage when blood vessels are strained, including the ones leading to the heart, making it much tougher to circulate blood in the body.

"This strain can damage the blood vessels, causing them to become harder and narrower, a condition called atherosclerosis. This makes a blockage more likely, which can cause a stroke or transient ischaemic attack (TIA, sometimes called a mini stroke)," said Satnam Singh Chhabra, Head Neuro and Spine Surgeon, Sir Ganga Ram Hospital.

According to these experts, the relationship between blood pressure (hypertension) and risk of stroke is strong. The higher is the blood pressure, the greater is the risk of stroke. 

Currently, over 16 lakh Indians suffer from stroke annually. 

Suggesting regular check-ups as the best way to diagnose hypertension, Chhabra said: "The good news is that many clinical trials have documented that drug treatment of hypertension prevents stroke and that anti-hypertensive drug treatment reduced the risk of strokes by 32 percent compared to no drug treatment".

"Medication and other lifestyle changes are required to control high blood pressure. Patients should understand that they should be very regular in taking medications, getting the blood pressure checked and visiting doctors to reduce the chances of organ damage due to hypertension," Chhabra said.​