Knowledge Update

​New York, April 10 (IANS) US researchers, led by an Indian-origin scientist, have developed a novel 3-D imaging tool that can provide highly accurate method to detect non-alcoholic fatty liver disease (NAFLD) that often begins without symptoms but can progress to cancer.

The researchers at the University of California, San Diego, conducted a prospective study of 100 patients (56 percent women) with biopsy-proven NAFLD to assess the efficacy of two-dimensional magnetic resonance elastography (MRE) and a novel 3D version. 

They found that both MRE technologies were highly accurate for diagnosing advanced fibrosis, with 3D perhaps providing additional capabilities in some patients.

"3D MRE is probably the most accurate non-invasive method to detect advanced fibrosis," said Rohit Loomba, the study's first author and director of the NAFLD Research Centre at UC San Diego School of Medicine.

MRE is a specialized version of magnetic resonance imaging (MRI) that propagates mechanical shear waves in liver tissue. An algorithm creates images that quantitatively measure tissue stiffness -- an indicator of fibrosis. 

The 2D version of MRE is already commercially available and easily implemented on basic MRI systems in clinics. Three-dimensional MRE is more technically demanding and not yet widely available.

The findings of the study, published recently in the American Journal of Gastroenterology, are encouraging because diagnosing NAFLD can be challenging. 

Current non-invasive techniques, such as molecular biomarkers in blood, are not sufficiently accurate for routine clinical use. Ultrasound-based methods have high failure rates, particularly in obese patients.

"These findings suggest that MRE could be used to enroll patients with advanced fibrosis into screening programs for cirrhosis as well as enrollment into clinical trials aimed at reversing fibrosis in the setting of advanced fibrosis," Loomba said.​

​Sydney, April 10 (IANS) A breakthrough chip for the nano-manipulation of light has pioneered new paths for developing next generation optical technologies and enabling deeper understanding of black holes.

Developed by a team of researchers at RMIT University in Melbourne, Australia, the integrated nanophotonic chip can achieve unparalleled levels of control over the angular momentum (AM) of light.

This means that now AM can be used at a chip-scale for the generation, transmission, processing and recording of information, and could also be used to help scientists better understand the evolution and nature of black holes.

While traveling approximately in a straight line, a beam of light also spins and twists around its optical axis. The AM of light measures the quantum of that dynamic rotation. 

Given the potential of using AM to enable the mass expansion of the available capacity of optical fibres, scientists have been trying to harness it on a chip scale.

"By designing a series of elaborate nano-apertures and nano-grooves on the photonic chip, our team has enabled the on-chip manipulation of twisted light for the first time," said Min Gu from RMIT University, who led the study that was published recently in the journal Science. 

"Our discovery could open up truly compact on-chip AM applications such as ultra-high definition display, ultra-high capacity optical communication and ultra-secure optical encryption," Gu added.

"It could also be extended to characterise the AM properties of gravitational waves, to help us gain more information on how black holes interact with each other in the universe," the researcher noted.​

London, April 10 (IANS) A formula taking into account the maximum mass of non-rotating neutron star has made it possible for scientists to calculate the critical mass when a rotating neutron star would collapse to become a black hole.

"It is quite remarkable that a system as complex as a rotating neutron star can be described by such a simple relation," said Luciano Rezzolla from the Goethe University in Frankfurt, one of the authors of the study.

Neutron stars have a mass that is up to twice that of the sun but a radius of only a dozen km, making them thousands of billions of times denser than that of the densest element on the Earth. 

But their mass cannot grow without bound. Indeed, if a non-rotating star increases its mass, its density also will increase. Normally this will lead to a new equilibrium and the star can live stably in this state for thousands of years. 

This process, however, cannot repeat indefinitely and the accreting star will reach a mass above which no physical pressure will prevent it from collapsing to a black hole. 

The critical mass when this happens is called the "maximum mass" and represents an upper limit to the mass that a non-rotating neutron star can be.

However, once the maximum mass is reached, the star also has an alternative to the collapse: It can rotate. 

A rotating star, in fact, can support a mass larger than if it was non-rotating, simply because the additional centrifugal force can help balance the gravitational force. 

Also in this case, however, the star cannot be arbitrarily massive because an increase in mass must be accompanied by an increase in rotation and there is a limit to how fast a star can rotate before breaking apart. Hence, for any neutron star there is an absolute maximum mass and is given by the largest mass of the fastest-spinning model.

Determining this value from first principles is difficult because it depends on the equation of state of the matter composing the star and this is still essentially unknown. Because of this, the determination of the maximum rotating mass of a neutron star has been an unsolved problem for decades. 

Scientists had to compute a very large number of stellar models to find the result, published recently in the journal Monthly Notices of the Royal Astronomical Society.

"Surprisingly, we now know that even the fastest rotation can at most increase the maximum mass of 20 percent at most," Rezzolla noted.

"This result has always been in front of our eyes, but we needed to look at it from the right perspective to actually see it," said Cosima Breu, a research student at the University of Frankfurt, who performed the analysis of the data during her bachelor thesis.

This simple but powerful result opens the prospects for more universal relations to be found in rotating stars. "We hope to find more equally exciting results when studying the largely unexplored grounds of differentially rotating neutron stars," Rezzolla said.​

​New York, April 10 (IANS) People with severe obesity who undergo bariatric surgery are likely to experience improvement in pain, physical function and walking ability, says a study.

The findings revealed that about 50-70 percent of adults experienced clinically significant improvements in perceived bodily pain and physical function and in objectively measured walking capacity.

The study's "large geographically diverse sample, inclusion of multiple validated measures of pain and physical function, longitudinal design, and follow-up through 3 years make it one of the most informative studies of pain and function following RYGB and LAGB to date," said Wendy C. King from the University of Pittsburgh in the US.

Severe obesity and excess weight can lead to joint damage and pain, resulting in limitations in walking and restricted other physical activities

The study, published in the journal JAMA, analysed 2,458 participants and was conducted at 10 hospitals. Of the participants, 79 percent were women with the median age 47 years and 2,221 completed baseline and follow-up assessments.

The assessments were conducted prior to surgery and annually thereafter.

Bariatric surgery is effective at achieving and maintaining weight loss, although the variability and durability of improvements in pain and physical function are not well described.

The team examined changes in pain and physical function in the first three years following bariatric surgery and factors associated with improvement, among adults with severe obesity.

Pre-surgery-to-post-surgery reductions in weight and depressive symptoms were associated with improvements in multiple outcomes.

About three-fourth of participants with severe knee and hip pain or disability at baseline experienced improvements in osteoarthritis symptoms.​

New York, April 10 (IANS) Researchers have determined that certain gastrointestinal tumours are more deadly than previously assumed.

Gastrointestinal stromal tumours (GISTs) may be malignant cancer or benign and are most commonly found in the stomach and small intestine and have significant variability in terms of size and malignant behaviour.

The finding, published online in the Journal of Gastrointestinal Surgery, showed that GISTs that are less than two cm cause 12.1 percent mortality rate for five years.

Also, up to 30 percent of patients have GISTs less than two cm in size, or slightly more than half an inch, the researchers noted.

More than 79 percent of patients have localised disease of GISTs, while for 11.4 percent the disease can spread to other regions. Previously, researchers did not expect any disease to have spread.

"While GISTs are rare, we have found that certain groups of these tumours result in a much higher mortality than expected," said Jason Sicklick, assistant professor at University of California-San Diego in US.

For the study, the team identified 378 patients with malignant GISTs of less than two cms between 2001 and 2011.​

London, April 11 (IANS) Ancestors of modern-day humans are thought to have wiped out the ancient Neanderthals from Europe by passing on diseases and infections when they moved out of Africa and into the continent previously dominated by them.

The Neanderthals, who would only have developed resistance to the diseases of their European environment, are most likely to have been infected with a bacterium that causes stomach ulcers, the virus that causes genital herpes, tapeworms and tuberculosis.

The researchers said that some infectious diseases are likely to be many thousands of years older than previously believed.

The diseases and infections to which the hunter-gatherers were exposed would have made them less able to find enough food and remain healthy. The diseases would have spread through sexual contact between the two species.

"Humans migrating out of Africa would have been a significant reservoir of tropical diseases," said Charlotte Houldcroft from the University of Cambridge in Britain.

"For the Neanderthal population of Eurasia, adapted to that geographical infectious disease environment, exposure to new pathogens carried out of Africa may have been catastrophic," Houldcroft added.

The findings showed Helicobacter pylori -- a bacterium that causes stomach ulcers -- as highly likely to have been passed by humans to Neanderthals. 

It is estimated to have first infected humans in Africa between 88,000 to 116,000 years ago, and in Europe 52,000 years ago.

Another likely candidate is herpes simplex 2 -- the virus that causes genital herpes. Evidence in the genome of this disease suggested that it was transmitted to humans in Africa 1.6 million years ago from another, currently unknown hominin species that in turn acquired it from chimpanzees.

The researchers have challenged the view that the spread of infectious diseases exploded with the evolution of agriculture about 8,000 years ago, which saw denser and more settled human populations coexisting with livestock.

Instead, genetic data showed that many infectious diseases have been "co-evolving with humans and our ancestors for tens of thousands to millions of years, and passed from them to the animals,” the researchers noted in the paper published in the American Journal of Physical Anthropology.

"Hunter-gatherers lived in small foraging groups. Neanderthals lived in groups of between 15-30 members, for example. So disease would have broken out sporadically, but have been unable to spread very far. Once agriculture came along, these diseases had the perfect conditions to explode, but they were already around,” Houldcroft maintained.

Recent theories for the cause of Neanderthal extinction range from climate change to an early human alliance with wolves resulting in domination of the food chain.

"It is probable that a combination of factors caused the demise of Neanderthals and the evidence is building that spread of disease was an important one," Houldcroft concluded.​

​London, April 11 (IANS) Assessing the relationship between gender, BMI and notion of 'attractiveness', a new study finds that weight is intrinsically linked to attractiveness and women are the harshest judges and most harshly judged.

The findings showed that females perceive men and women with higher body mass index (BMI) as less attractive and judge other women harshly about weight in relation to beauty.

Conversely, men do not judge another man with a higher weight negatively, but still see overweight women as less attractive.

"This is the first study that looks at the relationship between BMI and attractiveness, from both gender's perspective" explained Sonia Oreffice, professor of University of Surrey in Britain.

Further, the anthropometric attributes -- physical measures of a person's size, form, and functional capacities, play a significant role in wage regressions in addition to attractiveness, showing that body size cannot be dismissed as a simple component of beauty.

The study, published in the journal Economics and Human Biology, provides insight into the relationship between body size and beauty and the wage inequality associated with it.

Body size -- height for both men and women and BMI only for men -- explains wages above and beyond beauty.

This contributes to bridge the gap between studies on the economics of anthropometric measures (including height and BMI), on one hand, and the economics of beauty, on the other, estimating the relevance of body size and beauty, the researchers concluded.​

​London, April 10 (IANS) Instead of reading a label, consumers could soon be interacting with an electronic screen on packages in the future. Scientists from the University of Sheffield have developed a new way of attaching electronic screens to paper-based packaging where screens can display simple messages to customers -- a move that can revolutionise the packaging industry. "Labels on packaging can become much more innovative and allow customers to interact with and explore new products. The use of displays or light emitting panels on packaging will also allow companies to communicate brand awareness in a more sophisticated manner," said led researcher and professor David Lidzey. The team collaborated with technology company Novalia to create a new way of displaying information on packaging. It can be used in greeting cards or products where a customer could receive a simple message. Further developments can include a countdown timer on the side of a packet to indicate when a timed product was ready -- such as hair-dye, pregnancy tests or home-baking using a 'traffic lights' system. The process involves printing electronic tracks onto paper and then fixing low-cost electronics and a polymer LED display to the paper using an adhesive that conducts electricity. Scientists also designed and constructed a touch-pad keyboard on the paper that allows a user to selectively "drive" the LEDs in the display. The team's next steps are to create fully flexible organic displays on a plastic substrate that then fix onto the electronic tracks. The LED devices need to be low-cost and flexible enough to be used on all packaging. "The paper-based packaging industry is worth billions of dollars. This innovative system could give manufacturers a way to gain market share by being able to distinguish its products from competitors," noted Chris Jones from Novalia said in a paper published in the IEEE Journal of Display Technology.​

​Munich, April 12 (IANS) German car producer Audi AG on Tuesday announced that its sales in the Chinese market in the first quarter rose by 4.7 percent to 139,540 units. "Following a year of consolidation in 2015, Audi is once again on track for growth in China," Xinhua news agency cited Audi as saying its website. Statistics show that 50,986 cars were sold in March to customers in China, an increase of 5.4 percent and gains were seen particularly in the compact class. In addition, the four rings company also announced that it has achieved the best first quarter in the company's history along with the most successful sales month. The Ingolstadt-based company increased global sales by 4.6 percent to a monthly high of around 186,100 units in March, which brings cumulative deliveries since January to around 455,750 cars, four percent more than in the same quarter last year, according to a statement. "The strong demand in the first quarter confirms that we are on the right track to achieve another sales record for the full year in 2016," said Dietmar Voggenreiter, member of the board of management for sales and marketing.​

Dubai, April 11 (IANS) India-UAE trade has increased phenomenally in the last half century and at $60 billion per annum currently, has made the Gulf nation India's third largest trading partner since the last couple of years, Petroleum Minister Dharmendra Pradhan said on Monday.