Knowledge Update

New York, Feb 4 (IANS) Eating grapes daily can help protect the brain against early decline associated with Alzheimer's disease, show results of a pilot study involving people with early memory decline.

Alzheimer's disease is a brain disease that results in a slow decline of memory and cognitive skills. 

"The study examines the impact of grapes as a whole fruit versus isolated compounds and the results suggest that regular intake of grapes may provide a protective effect against early decline associated with Alzheimer's disease," said lead investigator of the study Daniel Silverman from University of California Los Angeles, US.

"This pilot study contributes to the growing evidence that supports a beneficial role for grapes in neurologic and cardiovascular health, however more clinical studies with larger groups of subjects are needed to confirm the effects observed here," Silverman added.

The study results, published in Experimental Gerontology, showed a grape-enriched diet protected against the decline of metabolic activity. 

Low metabolic activity in these areas of the brain is a hallmark of early stage Alzheimer's disease. 

Additionally, those consuming a grape-enriched diet also exhibited increased metabolism in other areas of the brain that correlated with individual improvements in attention and working memory performance, compared to those on the non-grape diet. 

In the study, participants with early memory decline were randomly selected to receive either whole grape powder -- equivalent to just a little over two cups of grapes per day -- or a polyphenol-free placebo powder matched for flavour and appearance. 

Cognitive performance was measured at baseline and six months later. Changes in brain metabolism, assessed by brain scans, were also measured at baseline and six months later. 

The results showed that consuming grapes preserved healthy metabolic activity in the regions of the brain that are affected by the earliest stages of Alzheimer's disease, where metabolic decline takes hold. 

Participants who did not consume grapes exhibited significant metabolic decline in these critical regions. 

Grape polyphenols help promote antioxidant and anti-inflammatory activities. 

Previous research had shown that grapes may help support brain health by working in multiple ways - from reducing oxidative stress in the brain to promoting healthy blood flow in the brain to helping maintain levels of a key brain chemical that promotes memory to exerting anti-inflammatory effects.

​New York, Feb 4 (IANS) Challenging a common perception that personality traits are ingrained, researchers have found that when preschoolers spend time around one another, they tend to take on each others' personalities.

The study, published online in the Journal of Personality and Social Psychology, suggests personality is shaped by environment and not just genes.

"Our finding, that personality traits are 'contagious' among children, flies in the face of common assumptions that personality is ingrained and can't be changed," said co-investigator on the study Jennifer Watling Neal, Associate Professor at Michigan State University in the US.

"This is important because some personality traits can help children succeed in life, while others can hold them back," she explained. 

For the study, the researchers studied two preschool classes for an entire school year, analysing personality traits and social networks for one class of three-year-olds and one class of four-year-olds.

Children whose play partners were extroverted or hard-working became similar to these peers over time. 

Children whose play partners were over-anxious and easily frustrated, however, did not take on these particular traits, the study said.

Los Angeles, Feb 3 (IANS) Bringing together more than 5,000 engineers and designers from across the globe to network, learn, share and discover the latest in 3D technologies, the global 3D design software company Dassault Systèmes on Friday announced "SOLIDWORKS World 2017".

Washington, Feb 3 (IANS) The dwarf planet Ceres may actually host many "hidden" ice volcanoes, besides the only one discovered recently, a study says.

NASA's Dawn spacecraft discovered Ceres's four-kilometre tall Ahuna Mons cryovolcano in 2015. 

Other icy worlds in our solar system, like Pluto, Europa, Triton, Charon and Titan, may also have such mountains of icy rock -- called cryovolcanoes -- but Ahuna Mons is conspicuously alone on Ceres. 

Now, in a paper accepted for publication in the journal Geophysical Research Letters, scientists showed there might have been cryovolcanoes other than Ahuna Mons on Ceres millions or billions of years ago, but these cryovolcanoes might have flattened out over time and become indistinguishable from the planet's surface. 

"We think we have a very good case that there have been lots of cryovolcanoes on Ceres but they have deformed," said lead study author Michael Sori of Lunar and Planetary Laboratory at University of Arizona in Tucson, US.

Ahuna Mons is a prominent feature on Ceres, rising to about half the height of Mount Everest. Its solitary existence has puzzled scientists since they spied it.

Adding to the puzzle are the steep sides and well-defined features of Ahuna Mons -- usually signs of geologic youth, Sori said. 

That leads to two possibilities. Ahuna Mons is just as it appears, inexplicably alone after forming relatively recently on an otherwise inactive world. Or, the cryovolcano is not alone or unusual, and there is some process on Ceres that has destroyed its predecessors and left the young Ahuna Mons as the solitary cryovolcano on the dwarf planet, according to Sori.

Ceres has no atmosphere, so the processes that wear down volcanoes on Earth -- wind, rain and ice -- are not possible on the dwarf planet. 

Sori and his colleagues hypothesised that another process, called viscous relaxation, could be at work.

Viscous relaxation is the idea that just about any solid will flow, given enough time. For example, a cold block of honey appears to be solid. But if given enough time, the block will flatten out until there is no sign left of the original block structure.

On Earth, viscous relaxation is what makes glaciers flow, Sori explained. 

"Ahuna Mons is at most 200 million years old. It just has not had time to deform," Sori said.

The researchers said they would next try and identify the flattened remnants of older cryovolcanoes on Ceres. 

The findings could help scientists better decipher the history of how the dwarf planet formed, Sori added.

​New York, Feb 3 (IANS) Sleep may be regulated in part by several brain-based immune proteins, says a study that could pave the way for new therapies to treat chronic sleep disorders and sleep disturbances secondary to other diseases.

The immune proteins -- collectively called inflammasome NLRP3 -- recruit a sleep-inducing molecule to trigger somnolence following sleep deprivation and exposure to a bacterial toxin, showed results of the study published in the journal Brain, Behavior, and Immunity.

Animals lacking genes for this protective immune complex showed profound sleep aberrations.

"Our research points, for the first time, to the inflammasome acting as a universal sensing mechanism that regulates sleep through the release of immune molecules," said study senior investigator Mark Zielinski from Harvard Medical School. 

In a series of experiments, the scientists demonstrated that following sleep deprivation or exposure to bacteria, the inflammasome activates an inflammatory molecule called interleukin-1 beta, known to induce sleep and promote sleep intensity. 

The brain cells of mice lacking the gene coding for inflammasome NLRP3 showed a marked absence of this sleep-inducing molecule.

Going a step further, the investigators compared the behaviour, sleep patterns and electrical activity in the brains of mice lacking the inflammasome gene to those in a group of mice with intact inflammasome genes.

Mice lacking the inflammasome gene had abnormal sleep responses following sleep deprivation. 

On average, such mice slept less and experienced more sleep interruptions than mice with their genes intact.

The latter group also slept more and harder following bacterial exposure -- the expected physiological response following infection, the researchers said.

Tokyo, Feb 3 (IANS) Examining a molecular cloud with enigmatic motion, a team led by researchers in Japan has found signs of stray black hole hiding in the Milky Way.

It is difficult to find black holes, because they are completely black. In some cases black holes cause effects which can be seen. 

Theoretical studies have predicted that 100 million to one billion black holes should exist in the Milky Way, although only 60 or so have been identified through observations to date. 

"We found a new way of discovering stray black holes," said one of the researchers Tomoharu Oka, Professor at Keio University in Japan.

The researchers used the ASTE Telescope in Chile and the 45-m Radio Telescope at Nobeyama Radio Observatory, both operated by the National Astronomical Observatory of Japan, to observe molecular clouds around the supernova remnant W44, located 10,000 light-years away from us. 

A supernova is the explosion of a star -- the largest explosion that takes place in space, according to NASA.

The primary goal of the researchers was to examine how much energy was transferred from the supernova explosion to the surrounding molecular gas, but they happened to find signs of a hidden black hole at the edge of W44, said the study published in Astrophysical Journal Letters.

During the survey, the team found a compact molecular cloud with enigmatic motion. 

To investigate the origin of this cloud, named the "Bullet", the team performed intensive observations of the gas cloud.

The data indicated that the Bullet seems to jump out from the edge of the supernova remnant with immense kinetic energy. 

"Most of the Bullet has an expanding motion with a speed of 50 km/s, but the tip of the Bullet has a speed of 120 km/s," Masaya Yamada, a graduate student at Keio University, said.

"Its kinetic energy is a few tens of times larger than that injected by the W44 supernova. It seems impossible to generate such an energetic cloud under ordinary environments," Yamada added.

The researchers believe that a dark and compact gravity source, possibly a black hole, has an important role in the formation of the Bullet.

Washington, Feb 2 (IANS) US Federal Reserve on Wednesday left the benchmark interest rates unchanged and offered no hint on when it might move.

The central bank painted a relatively upbeat picture for the economy. "Labour market continued to strengthen and... economic activity has continued to expand at a moderate

​Tokyo, Feb 2 (IANS) The online payment service for Nintendo Switch, the new console from the Japanese video game giant, will cost between 2,000 and 3,000 yen ($17-$26), company president Tatsumi Kimishima said on Thursday.

Juba, Feb 2 (IANS/MAP) Morocco King Mohammed VI and South Sudan President Salva Kiir Mayardit chaired the signing ceremony of nine bilateral agreements in different areas of cooperation between the two countries at the presidential palace in capital Juba.