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Knowledge Update

Your brain may be ready for action, even at rest

New York, March 11 (IANS) Even while you are taking rest, your brain networks may be waiting in a state of potentiation to execute even the simplest of behaviours, a finding that may help in improving treatments for neuropsychiatric syndromes, an Indian-origin researcher has showed.

In the study, the researchers studied brain network interactions between two important brain regions: the dorsal anterior cingulate cortex (dACC) -- used for control -- and the supplementary motor area (SMA) -- used for motor movements -- during a simple motor control behaviour, for example tapping forefinger to a visual cue.

The results, published in the journal PLoS One, showed that the network interactions from the SMA to the dACC increased, during the rest periods that alternated between the motor behaviour task.

"These results suggest that directional interactions from the SMA to the dACC during the rest period may in fact potentiate task-related interactions in the opposite direction," said Vaibhav Diwadkar, Professor at Wayne State University in Michigan, US.

For the study, the team used a simple experimental task, having each participant perform a simple motor control behaviour -- tapping their forefinger to a visual cue -- that alternated between behaviour and rest. Brain activity was acquired using functional MRI (fMRI). 

The results reveal aspects not only of normative brain function but may also provide new directions for characterising disordered network interactions in neuropsychiatric syndromes, Diwadkar added.

Fish eyes may help find cure for blindness

New York, March 11 (IANS) Scientists have discovered a chemical in the zebra fish brain that helps reveal how it regrows its retina, a finding that can potentially cure blindness in humans.

The findings showed that the levels of GABA (gamma aminobutyric acid), a neurotransmitter, best known for its role of calming nervous activity -- drop when the unique self repair process kicks in. 

Thus, blocking the chemical (GABA) could lead to new treatments for AMD (age related macular degeneration), the most common cause of blindness and and retinitis pigmentosa.

The structure of the retinas (the light sensing tissue at the back of the eye) of fish and mammals are basically the same and a reduction in GABA might be the trigger for retinal regeneration, the researchers said.

"Our theory is that a drop in GABA concentration is the trigger for regeneration," said James Patton, Professor at Vanderbilt University, in Tennessee, US.

"If we are correct, then it might be possible to stimulate human retinas to repair themselves by treating them with a GABA inhibitor," Patton added.

In the study, when the scientists injected drugs that kept GABA concentrations in the retinas of newly blinded fish at a high level, they found it suppressed the regeneration process.

After injecting an enzyme that lowers GABA levels in normal fish, they found that the Muller glia (retinal cells) began changing and proliferating, the first stage in the regeneration process.

The Muller glia (which in fish play a key role in regeneration) is a special type of adult stem cell.

When regeneration is triggered in zebrafish, the Muller glia begins proliferating and then differentiating into replacements for the damaged nerve cells.

NASA's 'Europa Clipper' mission to explore Jupiter's moon

Washington, March 10 (IANS) NASA has announced that its upcoming mission to explore the habitability of Jupiter's icy moon Europa will be officially called Europa Clipper.

The mission is being planned for launch in the 2020s, arriving in the Jupiter system after a journey of several years, NASA said in a statement on Friday.

Europa has long been a high priority for exploration because it holds a salty liquid water ocean beneath its icy crust. 

The ultimate aim of Europa Clipper is to determine if Europa is habitable, possessing all three of the ingredients necessary for life -- liquid water, chemical ingredients, and energy sources sufficient to enable biology, the US space agency said. 

Previously, when the mission was still in the conceptual phase, it was sometimes informally called Europa Clipper, but NASA has now adopted that name as the formal title for the mission.

The moniker harkens back to the clipper ships that sailed across the oceans of Earth in the 19th century. 

Clipper ships were streamlined, three-masted sailing vessels renowned for their grace and swiftness. 

These ships rapidly shuttled tea and other goods back and forth across the Atlantic Ocean and around globe.

In the grand tradition of these classic ships, the Europa Clipper spacecraft would sail past Europa at a rapid cadence, as frequently as every two weeks, providing many opportunities to investigate the moon up close. 

The prime mission plan includes 40 to 45 flybys, during which the spacecraft would image the moon's icy surface at high resolution and investigate its composition and the structure of its interior and icy shell.

"During each orbit, the spacecraft spends only a short time within the challenging radiation environment near Europa. It speeds past, gathers a huge amount of science data, then sails on out of there," said Robert Pappalardo, Europa Clipper project scientist at NASA's Jet Propulsion Laboratory in Pasadena, California.

Flire retardant chemicals linked to aggression in kids

New York, March 10 (IANS) Higher exposure to some chemicals added to furniture, electronics and numerous other goods to prevent fires may put kids at increased risk of developing aggression and hyperactivity, says a study.

The researchers studied the behavioural effects of organophosphate-based flame retardants (OPFRs) on young children.

"When we analysed behaviour assessments and exposure levels, we observed that the children who had more exposure to certain types of the flame retardant were more likely to exhibit externalising behaviours such as aggression, defiance, hyperactivity, inattention and bullying," said corresponding author of the study Molly Kile, Associate Professor at Oregon State University in the US. 

Flame retardants are found throughout the built environment in furniture, mattresses, carpeting, electronics, vehicles and more. 

The chemicals are added to the products and are not bound in the material, which causes them to be released into indoor environments.

For this study, published in the journal Environmental Health, the research team recruited 92 children between ages three to five to wear a silicone wristband for seven days to measure exposure to flame retardants.

The researchers had parents or primary caregivers complete questionnaires about socio-demographics and the home environment, and preschool teachers completed behaviour assessments for each participating child. 

In all, researchers had complete data and wristband results for 69 children.

Their analysis showed that all of the children were exposed to some level of flame retardant. 

Children who had higher exposure rates of OFPRs showed less responsible behaviour and more aggression, defiance, hyperactivity, inattention and bullying behaviours.

World's oldest, 152 mn years old crocodile eggs found in Portugal

London, March 10 (IANS) Researchers have found the world's oldest crocodilian eggs that were laid 152 million years ago.

The eggs, discovered in cliffs in Portugal, were laid by close relatives of "true" crocodiles, a group called crocodylomorphs, which according to palaeontologists, had been two metres long.

"The fact that they are from the Late Jurassic period makes these eggs the oldest crocodilian eggs known so far," Joao Russo from the Nova University of Lisbon in Portugal was quoted as saying to the BBC.

"The fossil record tells us that crocodiles and their relatives (forming the larger group of crocodylomorphs) were much more diverse in the past, with different feeding habits, ecological niche distribution or morphology," he added.

The eggs were found in several clutches and appear to be of two different types, the researchers said in the paper published in the journal, Plos One.

"This new discovery from Portugal extends the knowledge of this type of egg by approximately 40 million years," Russo added.

Why do people develop high blood pressure?

Moscow, March 10 (IANS) Early life changes in brain activity and blood flow may be the reason why people tend to develop abnormally high blood pressure, or hypertension, researchers said.

High blood pressure is a condition in which the force of the blood against the artery walls is too high.

It is also often called the silent killer because it typically has no symptoms until after it has done significant damage to the heart and the arteries.

In 90-95 per cent of people, high blood pressure has no identifiable cause, yet it is a risk factor for diseases of the brain, kidneys, heart, eyes, and other parts of the body, said a group of researchers at the Institute of Cytology and Genetics in Russia. 

For the study, published in Experimental Physiology, the team investigated physiological changes in a rat model called ISIAH, short for inherited stress-induced arterial hypertension.

These rats develop high blood pressure at four to six weeks of age, and this is sustained throughout their lifetime.

The researchers compared the high blood pressure rats to a control group with normal blood pressure. 

As the mice in high blood pressure group grew older, changes in rates of blood flow in certain arteries were observed.

In addition, changes were found in the brain activity, specifically a decrease in the prefrontal cortex -- the brain region associated with cognition, decision-making and working memory -- as well as an increase in the hypothalamus -- an area of the brain that controls mood and appetite.

"The study of early physiological changes may help clarify the cause of high blood pressure. Understanding this could help us prevent the disease early on," said led author Alisa Seryapina from the Institute of Cytology and Genetics.

Neanderthals had complex vegetarian diets: Australian research

Canberra, March 9 (IANS) Neanderthals have been revealed to have had complex vegetarian diets, while some also used plant-based medicines to treat illnesses, an Australian research revealed on Thursday.

Often thought of by many as simple "cave men" with only weak links to modern humans, Laura Weyrich from the Australian Centre for Ancient DNA has said analysis of Neanderthal dental plaque has revealed a varied and "modern-looking" vegetarian diet, Xinhua news agency reported.

"It's a very, very different picture from the grunting, club-toting Neanderthal that we like to think about," Weyrich told the Australian Broadcasting Corporation (ABC) on Thursday.

"They were probably very intelligent, communicative and very in tune with what was going on around them."

Weyrich revealed that some families of Neanderthal, such as the El Sidron group from modern Spain, ate a diet comprised mostly of plants and vegetables available in the forest.

She said there was evidence of pine nuts, mushrooms, grass and moss in the plaque analysis from the El Sidron Neanderthals.

"So that's the true palaeo diet," Weyrich said. "That's what people would have been eating in palaeolithic times if they lived in a forest like the El Sidron Neanderthal did."

In addition, Weyrich said the research uncovered evidence that Neanderthals used specific plants to try and treat a variety of illnesses, including using poplar bark - which happens to contain an active ingredient in Penicillium and aspirin - to counter the effects of gastrointestinal issues such as diarrhoea.

"So it is likely he would have been trying to self-medicate," Weyrich added.

NASA's Kepler hit by cosmic ray event while observing TRAPPIST-1

Washington, March 9 (IANS) NASA's planet-hunting Kepler space telescope was hit by a cosmic ray event during a recent campaign to observe TRAPPIST-1, a star system that hosts at least seven Earth-sized planets only 40 light-years away.

"During Campaign 12, a cosmic ray event reset the spacecraft's onboard software causing a five-day break in science data collection," NASA said in a statement on Wednesday.

"The benign event is the fourth occurrence of cosmic ray susceptibility since launch in March 2009. The spacecraft remains healthy and is operating nominally," the US space agency added while announcing the release of the data Kepler gathered about TRAPPIST-1.

On February 22, astronomers announced that the ultra-cool dwarf star, TRAPPIST-1, hosts a total of seven Earth-size planets that are likely rocky, a discovery made by NASA's Spitzer Space Telescope in combination with ground-based telescopes. 

Kepler space telescope also has been observing this star since December 2016. 

During the period of December 15, 2016 to March 4, the Kepler spacecraft, operating as the K2 mission, collected data on the star's minuscule changes in brightness due to transiting planets. 

These additional observations are expected to allow astronomers to refine the previous measurements of six planets, pin down the orbital period and mass of the seventh and farthest planet, TRAPPIST-1h, and learn more about the magnetic activity of the host star.

"Scientists and enthusiasts around the world are invested in learning everything they can about these Earth-size worlds," said Geert Barentsen, K2 research scientist at NASA's Ames Research Center at Moffett Field, California. 

"Providing the K2 raw data as quickly as possible was a priority to give investigators an early look so they could best define their follow-up research plans. We're thrilled that this will also allow the public to witness the process of discovery," Barentsen said.

The release of the raw, uncalibrated data collected will aid astronomers in preparing proposals due this month to use telescopes on Earth next winter to further investigate TRAPPIST-1, NASA said.

Potatoes may grow on Mars, suggests experiment

New York, March 9 (IANS) The preliminary results of an experiment confirm what the 2015 Hollywood science fiction film "The Martian" showed: potatoes can grow on Mars.

The International Potato Centre (CIP) in Lima, Peru, launched a series of experiments to discover if potatoes can grow under Mars atmospheric conditions and thereby prove they are also able to grow in extreme climates on Earth. 

The new phase of CIP's experiment to grow potatoes in simulated Martian conditions began on February 14 last year.

Based upon designs and advice provided by the NASA's Ames Research Centre in California, a tuber was planted in a specially constructed CubeSat contained environment built by engineers from the University of Engineering and Technology (UTEC) in Lima.

"If the crops can tolerate the extreme conditions that we are exposing them to in our CubeSat, they have a good chance to grow on Mars. We will do several rounds of experiments to find out which potato varieties do best," said Julio Valdivia-Silva from UTEC. 

"We want to know what the minimum conditions are that a potato needs to survive," he said in a statement released by CIP.

The CubeSat houses a container holding soil and the tuber. Inside this hermetically sealed environment, the CubeSat delivers nutrient-rich water, controls the temperature for Mars day and night conditions, and mimics Mars air pressure, oxygen and carbon dioxide levels. 

Live streaming cameras recording the soil showed potato sprouting in the simulated Martian conditions.

The results so far have been positive, the researchers said.

You too can gain super-sized memory with training

London, March 9 (IANS) Far from being limited to a gifted few, the ability to perform astonishing feats of memory, such as remembering lists of several dozen words, can be learned, say researchers.

In a study published in the journal Neuron, the researchers showed that after 40 days of daily 30-minute training sessions using a strategic memory improvement technique, individuals who had typical memory skills at the start and no previous memory training more than doubled their memory capacity.

From recalling an average of 26 words from a list of 72, the participants were able to remember on an average 62 words, the findings showed. 

Brain scans before and after training showed that strategic memory training altered the brain functions of the trainees, making them more similar to those of memory champions. 

"After training we see massively increased performance on memory tests," said study first author Martin Dresler, Assistant Professor of Cognitive Neuroscience at Radboud University Medical Centre in Nijmegen, The Netherlands. 

"Not only can you induce a behavioural change, the training also induces similar brain connectivity patterns as those seen in memory athletes," Dresler said.

To explore the effects of training on the brain, Dresler and his colleagues recruited 51 individuals with typical memory skills and no previous memory training. 

They were split into three groups -- two training groups and one group that did not train. The researchers scanned participants' brains before and after training.

The two training methods were short-term memory training and strategic memory training. 

During short-term memory training, an individual practices remembering sequences, a bit like playing the game Concentration. 

Strategic memory training provides trainees with a systematic way to remember lists.

In this study, the strategy Dresler chose was memory of loci training, which is employed by most world champion memory athletes. 

Using this strategy, items on a list are associated with a remembered place, and users navigate that remembered place as they recall the list. 

Those who trained using method of loci showed substantial improvement in their ability to recall lists of words. 

Before training, individuals could recall on average between 26 and 30 words. 

Afterwards, those with strategic memory training could recall 35 more words on average. 

Those who trained short-term memory could recall 11 more words. Those with no training recalled seven more words.

A day later, those who had trained still showed improvements in recall. 

Four months later, only those with strategic training continued to show substantial gains, still recalling over 22 more words than prior to training. 

"Once you are familiar with these strategies and know how to apply them, you can keep your performance high without much further training," Dresler said.