Knowledge Update

​New York, Jan 6 (IANS) By transforming the most common type of cells found in wounds into fat cells, researchers have reported finding a way to manipulate wounds to heal as regenerated skin rather than scar tissue.

"Essentially, we can manipulate wound healing so that it leads to skin regeneration rather than scarring," said principal investigator George Cotsarelis, Professor of Dermatology at Perelman School of Medicine at the University of Pennsylvania, US.

Fat cells called adipocytes are normally found in the skin, but they are lost when wounds heal as scars. The most common cells found in healing wounds are myofibroblasts, which were thought to only form a scar. 

Scar tissue also does not have any hair follicles associated with it, which is another factor that gives it an abnormal appearance from the rest of the skin.

Researchers used these characteristics as the basis for their work -- changing the already present myofibroblasts into fat cells that do not cause scarring.

"The secret is to regenerate hair follicles first. After that, the fat will regenerate in response to the signals from those follicles," Cotsarelis said.

The study showed hair and fat develop separately but not independently. Hair follicles form first, and the Cotsarelis lab previously discovered factors necessary for their formation. 

The new study - published online in the journal Science - details additional factors actually produced by the regenerating hair follicle to convert the surrounding myofibroblasts to regenerate as fat instead of forming a scar. 

As they examined the question of what was sending the signal from the hair to the fat cells, researchers identified a factor called Bone Morphogenetic Protein (BMP). It instructs the myofibroblasts to become fat. 

"Typically, myofibroblasts were thought to be incapable of becoming a different type of cell," Cotsarelis said. 

"But our work shows we have the ability to influence these cells, and that they can be efficiently converted into adipocytes," Cotsarelis noted.

This was shown in both the mouse and in human keloid cells grown in culture.

"The findings show we have a window of opportunity after wounding to influence the tissue to regenerate rather than scar," said the study's lead author Maksim Plikus, Assistant Professor at University of California, Irvine. 

The findings could lead to new therapies to help wounds heal without scarring.

​London, Jan 6 (IANS) Global warming is replicating conditions that triggered an abrupt sea level rise of several meters in the ocean around Antarctica some 15,000 years ago, warns a study.

"The changes that are currently taking place in a disturbing manner resemble those 14,700 years ago," said one of the researchers Michael Weber from University of Bonn in Germany.

At that time, changes in atmospheric-oceanic circulation led to a stratification in the ocean with a cold layer at the surface and a warm layer below. 

Under such conditions, ice sheets melt more strongly than when the surrounding ocean is thoroughly mixed. 

This is exactly what is presently happening around the Antarctic, said the study published in the journal Scientific Reports.

"The reason for the layering is that global warming in parts of Antarctica is causing land based ice to melt, adding massive amounts of freshwater to the ocean surface," Chris Fogwill from the Climate Change Research Center in Sydney explained.

"At the same time as the surface is cooling, the deeper ocean is warming, which has already accelerated the decline of glaciers in the Amundsen Sea Embayment (in West Antarctic ice sheet)," Fogwill added.

To investigate the climate changes of the past, the scientists studied the frozen "climate archive" - drill cores from the Antarctic ice sheet. 

"The largest melt occurred 14,700 years ago. During this time the Antarctic contributed to a sea level rise of at least three meters within a few centuries," Weber noted.

The research team used isotopic analyses of ice cores from the Weddell Sea region -- southernmost tip of the Atlantic Ocean - which now flows into the ocean about a quarter of the Antarctic melt.

Through a combination of ice sheet and climate modelling, the isotopic data showed that the waters around the Antarctic were heavily layered at the time of the melting events, so that the ice sheets melted at a faster rate. 

"The big question is whether the ice sheet will react to these changing ocean conditions as rapidly as it did 14,700 years ago," co-author Nick Golledge from Antarctic Research Centre in Wellington, New Zealand, said.

​London, Jan 6 (IANS) Consuming foods such as bananas, potatoes, grains and legumes that are rich in resistant starch may help check blood sugar, enhance satiety as well as improve gut health, a study has found.

Resistant starch is a form of starch that is not digested in the small intestine and is therefore considered a type of dietary fibre.

"We know that adequate fibre intake -- at least 30 grams per day -- is important for achieving a healthy, balanced diet, which reduces the risk of developing a range of chronic diseases," said Stacey Lockyer, Nutrition Scientist at British Nutrition Foundation, a Britain-based charity. 

Apart from occurring naturally in foods, resistant starch is also produced or modified commercially and incorporated into food products.

Unlike the typical starch, resistant starch acts like a type of fibre in the body as it does not get digested in your small intestine, but is is fermented in the large intestine.

This dietary fibre then increases the production of short chain fatty acids in the gut, which act as an energy source for the colonic cells, thus improving the gut health and increasing satiety.

According to the researchers, there is consistent evidence that consumption of resistant starch can aid blood sugar control. It has also been suggested that resistant starch can support gut health and enhance satiety via increased production of short chain fatty acids.

"Whilst findings support positive effects on some markers, further research is needed in most areas to establish whether consuming resistant starch can confer significant benefits that are relevant to the general population. However, this is definitely an exciting area of nutritional research for the future," Lockyer said.

The study was published in the journal Nutrition Bulletin.

Washington, Jan 6 (IANS) Humans likely established permanent settlements on the high-altitude Tibetan plateau at least 7,400 years ago, much before the advent of agriculture 5,200 years ago, says a study.

The findings are based on an extensive analysis of human handprints and footprints found in 1998 in fossilised hot spring mud near the village of Chusang on Tibet's central plateau, at an elevation of 14,000 feet above sea level. 

Analysis of the archaeological site indicated that the prints were made by people at least 7,400 years ago, and possibly as early as 13,000 years ago. 

The findings, published in the journal Science, challenge the previously held view that permanent human occupation of the Tibetan Plateau began no earlier than development of an agricultural economy between 5,200-3,600 years ago.

"Although an agropastoral lifeway may have enabled substantial population growth after 5,000 years, it by no means was required for the early, likely permanent, occupation of the high central valleys of the Tibetan Plateau," the researchers wrote.

The research sheds new light on human colonisation of high-elevation environments, said one of the researchers, Randy Haas from University of Wyoming in the US.

For example, researchers have been puzzled by the striking differences in how Tibetans and Andean highlanders adapted physiologically to the rigors of life at high elevations.

"High-elevation environments were some of the last places in the world that humans colonised, and so they offer something of a natural laboratory for studying human adaptation," Haas said.

​New York, Jan 5 (IANS) Researchers have spotted for the first time an extremely rare type of galaxy whose elliptical-like core is surrounded by two circular rings.

Approximately 359 million light years away from the Earth, the galaxy appears to belong to a class of rarely observed, Hoag-type galaxies, the researchers said.

"Less than 0.1 per cent of all observed galaxies are Hoag-type galaxies," said lead author Burcin Mutlu-Pakdil from the University of Minnesota at Duluth in the US.

Hoag-type galaxies are round cores surrounded by a circular ring, with nothing visibly connecting them. 

The majority of observed galaxies are disc-shaped like our own Milky Way. 

Galaxies with unusual appearances give astronomers unique insights into how galaxies are formed and change.

The researchers collected multi-waveband images of the galaxy, which is easily observable only in the Southern Hemisphere, using a large diameter telescope in the Chilean mountains. 

These images were used to determine the age of the two main features of the galaxy, the outer ring and the central body.

While the researchers found a blue and young (0.13 billion years) outer ring, surrounding a red and older (5.5 billion years) central core, they were surprised to uncover evidence for second inner ring around the central body. 

To document this second ring, researchers took their images and subtracted out a model of the core. 

This allowed them to observe and measure the obscured, second inner ring structure, according to a study published in the Monthly Notices of the Royal Astronomical Society.

"We've observed galaxies with a blue ring around a central red body before, the most well-known of these is Hoag's object. However, the unique feature of this galaxy is what appears to be an older diffuse red inner ring," said the co-author of the study, Patrick Treuthardt, an astrophysicist at the North Carolina Museum of Natural Sciences.

Galaxy rings are regions where stars have formed from colliding gas. 

"The different colours of the inner and outer ring suggest that this galaxy has experienced two different formation periods," Mutlu-Pakdil said.

Hanoi, Jan 5 (IANS) The Vietnamese population that has been forecast to grow at a slower pace will hit 100 million people by 2025, according to the Institute of Public Policy and Management (IPPM) on Thursday.

The country has maintained steady low birth rate as local people have been aware of benefits of small-scale families, Giang Thanh Long, IPPM director under Hanoi-based National Economics University said.

The expert said Vietnam has stepped into the aging process and would soon become a country with an aging population, Xinhua news agency reported.

Vietnam has been following the 'golden population structure' -- for every two people working, there is only one dependent person.

According to the latest figure by the General Statistics Office, Vietnam's average population in 2016 was estimated at 92.7 million people, up 1.08 percent compared to 2015.

The country's population was expected to reach 110 million people by mid-century, said Long.

​New York, Dec 25 (IANS) When exposed to cancer treatment like chemotherapy and radiation, brain and heart tissues in very young children are more prone to apoptosis or programmed cell death, researchers said.

Apoptosis, in which molecular signals order cells to self-destruct, plays an important role in deciding the "fate" of a developing cell.

These toxic treatment stressors put young children at high risk for developing severe, long-lasting impairments in their brain, heart, the study said.

But active apoptosis in the early brain "also sets the stage for extremely high sensitivity to any type of damage or stress, especially that induced by radiation or chemotherapy," said lead author Kristopher A. Sarosiek, Assistant Professor at the Harvard T.H. Chan School of Public Health.

While some cancer cells die through apoptosis, some escape the death orders by activating "pro-survival" signals.

Anthony Letai from Dana-Farber Cancer Institute in Massachusetts, developed a test called BH3 profiling that can measure inside any cell the relative dominance of pro-survival or pro-death signals.

A cancer cell in which apoptotic death signals are dominant, is said to be "highly primed" or ready for self-destruction and therefore easily killed by therapy, while a cell with low priming is more resistant to death or damage.

Measuring the priming of cells in normal cells and tissues, the researchers found that in most normal adult tissues, including the brain and the heart, the machinery needed to perform apoptosis is nearly completely absent.

In contrast, this molecular machinery is abundant in newborn and very young rodents. As a result, brain and heart cells were therefore much more vulnerable to undergoing cell death when exposed to chemotherapy or radiation.

When tested in human cells, the youngest human brain cells were more highly primed with apoptotic machinery and vulnerable to chemotherapy and radiation damage.

Human brain and heart cells are most highly primed for apoptosis until four to six years of age, after which priming continues to be reduced, the researchers noted, in the paper appearing in the journal Cancer Cell.

​Beijing, Jan 5 (IANS) Two Chinese companies have signed a contract to construct skyscrapers in the Cambodian capital of Phnom Penh, whose height will exceed the Petronas Towers in Kuala Lumpur, currently the tallest twin towers in the world.

Within a period of five years, Sino Great Wall International and the Wuchang Shipbuilding Industry Group will together build the towers, rising to a height of 560 metres - 108 metres more than the Petronas. 

The new towers will stand on the banks of the Mekong river, making them the fifth and sixth tallest buildings in the world, the China Daily reported on Thursday.

The project, having a $2.7 billion budget and signed on December 31, is financed by Cambodia's Thai Boon Roong Group while Macao-based Sun Kian Ip Group will be its co-developer.

The twin towers and the adjacent buildings, which are part of the project, will accommodate offices, apartments, hotels and malls as well as entertainment facilities, according to officials.

In recent years, the Chinese builders have embarked on significant large skyscraper projects in many cities in their country, and as a result nearly half the buildings measuring over 300 meters in the world are situated in China.

Among them is the world's second highest building, the 632-metre high Shanghai Tower, which has the highest observation deck surpassing the one at Burj Khalifa, the world's tallest skyscraper (828 metres) in Dubai. 

​New York, Jan 5 (IANS) Scientists have developed a new drug compound that has the potential to stop the spread of melanoma -- the most deadly form of skin cancer -- by up to 90 per cent.

About 10,000 people are estimated to die each year from melanoma, which spreads throughout the body quickly and attacks distant organs such as the brain and lungs. 

"The majority of people die from melanoma because of the disease spreading. Our compound can block cancer migration and potentially increase patient survival," said Richard Neubig, Professor at the Michigan State University. 

The study showed that the compound reduced the migration of melanoma cells by 85-90 per cent. 

The new drug also reduced tumours, specifically in the lungs of mice that had been injected with human melanoma cells, the researchers said.

The findings are an early discovery that could be highly effective in battling the deadly skin cancer, added Kate Appleton, a postdoctoral student at Michigan State University. 

The man-made small-molecule drug compound goes after a gene's ability to produce RNA molecules and certain proteins in melanoma tumours. 

This gene activity, or transcription process, causes the disease to spread but the compound can shut it down.Until now, few other compounds of this kind have been able to accomplish this, the researchers stated.

The compounds were able to stop proteins, known as Myocardin-related transcription factors, or MRTFs, from initiating the gene transcription process in melanoma cells. 

These triggering proteins are initially turned on by another protein called RhoC, or Ras homology C, which is found in a signalling pathway that can cause the disease to spread in the body aggressively.

"The effect of our compounds on turning off this melanoma cell growth and progression is much stronger when the pathway is activated. We could look for the activation of the MRTF proteins as a biomarker to determine risk, especially for those in early-stage melanoma," Appleton said, in the paper published in the journal Molecular Cancer Therapeutics.

​Beijing, Jan 5 (IANS) Chinese scientists are drawing a 1:2.5 million scale geological map of the Moon, a media report said on Thursday.

Ouyang Ziyuan, first chief scientist of China's lunar exploration programme, said five universities and research institutes have set standards for digital mapping and drawing of the Moon's geological structure.

A sketch version of the map, 4.36 metres by 2.2 metres, would be finished by 2018, and released by 2020, Xinhua news agency reported.

The map would provide information on geology, structure and rock types and would reflect the timeline of the Moon's evolution.

Chen Shengbo, a geologist with Jilin University in China, and his team are responsible for drawing the lunar structure outline, which was just one part of the work. 

He said the map would clearly show lunar geography, such as geographic fractures and the size, appearance, and the structure of craters.

Chen said mapping depends on data and images sent by circumlunar satellites from home and abroad. 

Lunar map making was not like drawing a map of the Earth, where scientists can go to the scene in person if they were not sure of their information.

China's satellites have captured images of the Moon, which contribute to the precision of lunar maps.