Knowledge Update

New York, Jan 3 (IANS) The eggs of non-avian dinosaurs took nearly between three to six months to hatch, similar to crocodiles and lizards, which explains the reason behind the extinction of the dinosaur species, scientists have found.

It was long assumed that the duration of dinosaur incubation was similar to birds, whose eggs hatch within 11 to 85 days, but they are more like of reptiles whose eggs take weeks to months to hatch.

"Some of the greatest riddles about dinosaurs pertain to their embryology -- virtually nothing is known. Did their eggs incubate slowly like their reptilian cousins? Or rapidly like living dinosaurs -- the birds," asked lead author Gregory Erickson, Professor at Florida State University. 

For the study, the team examined the fossilised teeth of two extremely well-preserved ornithischian dinosaur embryos: Protoceratops -- a pig-sized dinosaur, whose eggs weighed 194 grams -- and Hypacrosaurus -- a very large duck-billed dinosaur, with eggs weighing more than 4-kg.

Analysing the pattern of "von Ebner" lines -- the growth lines that are present in the teeth of all animals, as well as humans --, the researchers found that the Protoceratops embryos were about three months old when they died and the Hypacrosaurus embryos were about six months old. 

"These are the lines that are laid down when any animal's teeth develops. They're kind of like tree rings, but they are put down daily. And so we could literally count them to see how long each dinosaur had been developing," Erickson added.

In addition, the study found that the prolonged incubation may have affected dinosaurs' ability to compete with more rapidly generating populations of birds, reptiles, and mammals following the mass extinction event that occurred 65 million years ago. 

The long incubation period also exposed the non-avian dinosaur eggs and attending parents to predators, starvation, and environmental disruptions such as flooding, the researchers stated, in the paper published in the journal PNAS.

​New York, Jan 3 (IANS) Seven Zika virus proteins, believed to cause conditions, including birth defects such as microcephaly and neurological problems such as Guillain-Barre syndrome, have been identified.

"The mechanism of Zika virus has been a real mystery," said lead researcher Richard Zhao, Professor at University of Maryland School of Medicine (UM SOM). 

"These results give us crucial insight into how Zika affects cells. We now have some really valuable clues for future research," Zhao added.

Zika virus infected hundreds of thousands of people around the world, mostly in the Americas. No vaccines or treatments to prevent or treat the symptoms of Zika infection has been developed yet.

To test the virus, Zhao used fission yeast -- a species that in recent years has become a relatively common way to test how pathogens affect cells. 

For the experiment, Zhao separated each of the virus's 14 proteins and small peptides from the overall virus. He then exposed yeast cells to each of the 14 proteins, to see how the cells responded. 

Seven of the 14 proteins harmed or damaged the yeast cells in some way, inhibiting their growth, damaging them or killing them.

The next step is to understand more about how these seven proteins work in humans. It may be that some of them are more damaging than others, or perhaps all of them work in concert to cause harm, the researchers said. 

The study was published in the journal Proceedings of the National Academy of Sciences (PNAS).

​London, Jan 2 (IANS) New garden villages and towns will be built across England in an attempt to alleviate the housing crisis, the government said.

The villages will not be extensions of existing small towns or villages, but "distinct new places with their own community facilities," the Guardian quoted authorities as saying on Monday.

Sites from Cornwall to Cumbria have been identified in the first round of approved locations, making them eligible for a share of a £6 million ($7,39,6440) government technical and financial support fund. 

After completion, the villages may vary in size from 1,500 homes up to 10,000.

The development of the villages would be locally led by communities rather than central government, said Housing Minister Gavin Barwell. 

"New communities not only deliver homes, they also bring new jobs and facilities and a big boost to local economies," he said.

The 600-acre former Deenethorpe airfield near Corby, Northamptonshire, is one of the sites that has been approved for a village. The plans include a village green, shops and community hall, as well as more than 1,000 homes.

Dunton Hills, a garden village set to be built near Brentwood, Essex, will have at least 2,500 homes, as well as new Gypsy and Traveller pitches.

Three new garden towns have also been announced near Aylesbury in Buckinghamshire, Taunton in Somerset, and Harlow and Gilston in Hertfordshire.

Announcing the scheme, the Housing Minister said the villages will create almost 50,000 new homes from Cheshire down to Devon, while the towns will take the total to 200,000 new homes.

Other planned villages include Long Marston in Warwickshire, Spitalgate Heath in Lincolnshire, Bailrigg in Lancaster and the Infinity garden village in Derbyshire.

The final six are Oxfordshire Cotswold, Culm in Devon, Welborne in Hampshire, Halsnead in Merseyside, Longcross in Surrey and St Cuthberts near Carlisle.

The garden village initiative was announced by the then chancellor George Osborne last year.

The government has announced seven garden towns and cities to date but the 14 new villages are the first of a new kind of development designed to alleviate concerns about large-scale schemes swamping existing towns.

Sydney, Jan 2 (IANS) The rapid growth in wing length of a common Western Australian bird may be related to climate change, according to a study released on Monday.

Scientists from the University of Notre Dame in Sydney linked the growth in wing length of the Australian ringneck parrot, or Barnardius zonarius, to climate change as the limbs of animals in warm climates tend to be longer, Efe news reported.

The wings of the parrot lengthened 4 to 5 cm in the last 45 years.

As temperatures rise, the increase in the length of wings can help these birds release excess heat and adapt better to their environment, said one of the study's scientists, Dylan Korczynskyj.

Korczynskyj explained that the biggest changes in wing length have occurred since the 1970s, a period that coincides with temperature changes of more than 0.1 to 0.2 degrees Celsius and deforestation carried out in the state of Western Australia.

Although temperature variation appears minimal, the impact on the environment is significant, as evidenced by research on the bird species, he added.

The study examined several specimens from the museum of Western Australia, which has a collection of birds dating back to the early 19th century and includes a ringneck parrot specimen from 1904.

​New York, Jan 1 (IANS) Researchers have designed molecules with the potential to deliver healing power to stressed cells -- such as those involved in heart attacks.

The research, at a cellular level in the laboratory, involves organic molecules that break down to release hydrogen sulphide when triggered by specific conditions such as increased oxidative stress.

Oxidative stress damages cells and is tied especially to heart disease and cancer as well as Alzheimer's and Parkinson's disease.

"We have discovered that small organic molecules can be engineered to release a molecule called carbonyl sulphide, which is the most prevalent sulphur-containing molecule in the atmosphere, but more importantly converts rapidly to hydrogen sulphide under biological conditions," said study co-author Michael Pluth, Professor at the University of Oregon in the US.

"We developed and demonstrated a new mechanism to release small molecules that provide therapeutic hydrogen sulphide," Pluth said.

Hydrogen sulphide, a colourless gas, has long been known for its dangerous toxicity -- and its telltale smell of rotten eggs -- in the environment, but it also is produced in mammals, including humans, with important roles in molecular signalling and cardiac health.

One of the goals of developing these small hydrogen sulphide-releasing molecules is the potential for long-term applications in therapeutics, Pluth said.

Separate portions of the research were detailed in the Journal of the American Chemical Society and in an international journal Angewandte Chemie.

​New York, Jan 1 (IANS) A gene mutation linked to Alzheimer's disease and other age-related cognitive declines in our relatively safe and sterile post-industrial setting might have actually helped protect us from cognitive decline in ancient times, a new research suggests.

The findings suggest that a genetic mutation (or allele) that puts populations at risk for illnesses in one environmental setting could manifest itself in positive ways in a different setting.

"It seems that some of the very genetic mutations that help us succeed in more hazardous time periods and environments may actually become mismatched in our relatively safe and sterile post-industrial lifestyles," said lead author Ben Trumble, Assistant Professor at the Arizona State University in the US.

In a paper published in The FASEB Journal, the researchers examined how the apolipoprotein E (ApoE) gene might function differently in an infectious environment than in the urban industrialised settings where ApoE has mostly been examined.

All ApoE proteins help mediate cholesterol metabolism, and assist in the crucial activity of transporting fatty acids to the brain.

But in industrialised societies, ApoE4 variant carriers also face up to a four-fold higher risk for Alzheimer's disease and other age-related cognitive declines, as well as a higher risk for cardiovascular disease.

The goal of this study was to reexamine the potentially detrimental effects of the globally-present ApoE4 allele in environmental conditions more typical of those experienced throughout our species' existence -- in this case, a community of Amazonian forager-horticulturalists called the Tsimane.

"For 99 per cent of human evolution, we lived as hunter gatherers in small bands and the last 5,000-10,000 years -- with plant and animal domestication and sedentary urban industrial life -- is completely novel," Trumble said.

Due to the tropical environment and a lack of sanitation, running water, or electricity, remote populations like the Tsimane face high exposure to parasites and pathogens, which cause their own damage to cognitive abilities when untreated.

As a result, one might expect Tsimane ApoE4 carriers who also have a high parasite burden to experience faster and more severe mental decline in the presence of both these genetic and environmental risk factors.

But researchers discovered the exact opposite when they tested these individuals using a seven-part cognitive assessment and a medical exam.

In fact, Tsimane who both carried ApoE4 and had a high parasitic burden displayed steadier or even improved cognitive function in the assessment versus non-carriers with a similar level of parasitic exposure.

This indicated that the allele potentially played a role in maintaining cognitive function even when exposed to environmental-based health threats.

​London, Jan 2 (IANS) Scientists have for the first time identified a mechanism that regulates rhythmic brain waves that play a key role in making our memories permanent.

Memories undergo a consolidation process which stabilises and makes them become stronger -- a process where brain waves play an important role, the study said. 

The study revealed that one of the brain waves -- sharp wave ripples (SWRs) -- needed for consolidating memories is dominated by synaptic inhibition. 

It helps the brain set what an individual has learned or experienced as a quick instant replay.

SWRs is one among the three major brain waves coming from the hippocampus region of the brain that plays a key role in our memory making.

"Our results were able to show that precisely timed synaptic inhibition is the current generator for sharp wave ripples," said Peter Jonas, Professor at the Institute of Science and Technology Austria (IST Austria).

In the study, conducted in mice, the team set out to find the SWR mechanism -- whether ripples are caused by a temporal modulation of excitation or of inhibition at connecting points in brain cells, or synapses. 

The findings showed that the frequency of both excitation and inhibitor events at the synapse increased during the SWR.

But, synaptic inhibition was found to dominate over excitation during the production of SWRs, which means synaptic inhibition is responsible for forming the shape and rhythm of sharp wave ripples. 

Finally, the researchers also identified the neurons -- PV+ interneurons -- that provide inhibitory output onto other neurons and are mainly responsible for creating SWRs.

"Inhibition ensures the precise timing of neuronal firing. This could be critically important for preplay or replay of neuronal activity sequences and the consolidation of memory. 

"Inhibition may be the crucial player to making memories permanent," explained Jian Gan, post-doctoral student at IST Austria, in the paper published in the journal Neuron.

​New York, Jan 1 (IANS) Premixed complementary foods sold in lower-income countries lack consistency in their nutritional content, a global analysis of infant cereals has revealed.

The findings suggest that there is a need for basic quality assurance services to improve nutritional consistency and healthy growth of infants from 6 to 24 months age.

Premixed infant cereals or complementary foods can be a vital source of the solid food needed for healthy child growth after the age of six months, when infants outgrow the nutrients provided by breast milk alone.

This conclusion was reached after researchers from Tufts University in the US analysed 108 commercially available premixed complementary foods from 22 low-and-middle-income countries.

The findings, published in the journal Maternal and Child Nutrition, said premixed complementary foods can be extremely effective at protecting infants against malnutrition and stunted growth.

"In countries where we sampled, some products can readily meet children's needs, but others fall far below requirements for both macro and micro-nutrients," said William Masters from Tufts University.

"Our results are a call to action for establishing and enforcing nutritional quality standards, which would help ensure access to lower-cost, higher-quality products and enable parents to meet their infants' needs more easily," he added.

Researchers said that childhood malnutrition was the main cause of stunted growth, that may lead to delayed mental development and poor school performance -- a serious and irreversible condition that affects individuals with greater risk for illness and death throughout their lives.

According to Unicef, nearly half of all deaths in children under age five are related to undernutrition, which is particularly widespread in Africa and Asia.

"A healthy child consuming breast milk alongside the average sampled complementary food would experience zinc and iron deficiency from six to nine months, and dietary fat deficiency at 12 months," the study said.

The study noted that nutritional content claims on packaging labels did not meet their reported caloric content.

"Slightly more than half of the products misreported protein, and two thirds misreported fat content. For zinc and iron, products exceeded labelled values about as often as they fell short," the study further added.

​Tokyo, Dec 26 (IANS) Examining cucumber seedlings germinated under the very weak gravity -- or microgravity -- conditions of the International Space Station, researchers from Japan's Tohoku University have discovered how a protein helps plants sense gravity to boost their chances of survival.

Plants are experts in survival and can control the direction of their roots to maximise the use of resources around them. 

Using specialised cells, they can sense gravity and redistribute hormones, called auxins, to stimulate growth and allow vital features of the plant to develop. 

However, a big puzzle is how this transport process occurs at a cellular level.

In this study, reported in the journal Nature Microgravity and using samples grown on board the International Space Station, the research team highlighted the valuable contribution of the gravity-sensitive CsPIN1 protein to this process. 

The role of the protein in facilitating the transport of the growth hormones had first been suggested in previous experiments conducted on Earth.

To gain further insight, the researchers loaded cucumber seeds into specially designed canisters, which were sent up to the space station. 

Cucumbers were chosen for the study as they -- like other "cucurbitaceous" seedlings such as melons, pumpkins and squash -- feature specialised protuberances, or pegs, whose formation is regulated by gravity. 

These pegs form during the plant's early growth stage to help the seedlings emerge from their hard seed coat and anchor the developing plant in the soil while its roots form.

The experiment showed that CsPIN1 protein can relocalise under the influence of gravity.

Specifically, this change in the position of protein was found to occur in the so-called transition zone of the cucumber seedling where the pegs develop. 

This behaviour stimulates the formation of a cellular canal capable of transporting growth hormones from one side of this zone to the other, the study said.

Put simply, these findings point towards the mechanism by which the seeds are able to turn on and off the growth of their anchoring pegs in relation to their orientation with respect to gravity. And, as result, boost their chances of survival.

​Tokyo, Dec 27 (IANS) The Japanese government has adopted a series of emergency measures to prevent deaths due to overwork, following the deaths of two employees of a prominent advertising agency that became public recently, officials said on Tuesday.

The measures, approved Monday by the Labour Ministry and published by financial daily Nikkei, aim to increase monitoring of companies to ensure compliance with overtime laws.

Besides conducting surprise inspections at companies, authorities will also publicly reveal the names of firms which have seen cases of "karoshi", or death caused by overwork, as also those which force their staff to work extra hours beyond the legally allowed limit of 80 hours overtime a month, Efe news reported.

In October, the government published a report in response to such cases, which showed nearly a fourth of the country's workforce could be exceeding this limit.

The new measures, which will come into effect in January 2017, also include steps to advise companies on labour laws and foster medical and psychological help for employees who may be suffering from fatigue or work-related stress.

Concern and debate over excess work has been revived in the archipelago after the suicide of a 24-year-old female employee of Dentsu - the leading advertising firm in Japan - was confirmed to be a case of "karoshi" in October.

She had reportedly worked 105 extra hours the month before her death, although the company records reflected overtime within the permissible limit.

Her family alleged the company had forced her to indicate lesser hours than those she had actually worked.

The young woman, who died in December 2015 and who had been hired only seven months earlier by the company, had previously tweeted about having worked up to 20 hours a day.

Days after the confirmation of her case as karoshi, the death of another Dentsu employee in 2013 was also established to have been caused by excessive work.

The Japanese government last year approved a law to address problems caused by excessive work, but the lack of rigor on recording of extra hours by firms, and the staff's willingness to extend their working hours to earn a bonus makes it difficult to control the practice.